Neutrophilic-chronic myeloid leukemia: a distinct disease with a specific molecular marker (BCR/ABL with C3/A2 junction)

abstract：:Vaccination with antigen-presenting cells (APCs) engineered to mimic mechanisms of immune stimulation represents a promising approach for cancer immunotherapy. Dendritic cell vaccines have entered phase 3 testing in adult malignancies, but such vaccines in children have been limited. We demonstrate that CD40-activated...

journal_title：Blood

authors： Coughlin CM,Vance BA,Grupp SA,Vonderheide RH

更新日期：2004-03-15 00:00:00

abstract：:Platelets from patients with Montreal platelet syndrome (MPS) consistently display a defect in the mechanisms that regulate platelet size during shape change and undergo spontaneous aggregation and stir-induced microaggregate formation. We now provide data that the surface glycoprotein composition of MPS platelets is ...

journal_title：Blood

authors： Okita JR,Frojmovic MM,Kristopeit S,Wong T,Kunicki TJ

更新日期：1989-08-01 00:00:00

abstract：:Sequencing the complete factor IX gene of 2 sisters with hemophilia B with different phenotypes and no family history of hemorrhagic diathesis revealed a common 5' splice site mutation in intron 3 (T6704C) in both and an additional missense mutation (I344T) in one. The presence of dysfunctional antigen in the latter s...

journal_title：Blood

authors： Costa JM,Vidaud D,Laurendeau I,Vidaud M,Fressinaud E,Moisan JP,David A,Meyer D,Lavergne JM

更新日期：2000-08-15 00:00:00

abstract：:The anti-CD33 antibody calicheamicinconjugate gemtuzumab ozogamicin (GO) was used to treat 16 patients with acute promyelocytic leukemia (APL) who had relapsed at the molecular level. Of these patients, 8 were experiencing a first, 5 a second, 2 a third, and 1 a fourth relapse. GO was administered at 6 mg/m2 for 2 dos...

journal_title：Blood

authors： Lo-Coco F,Cimino G,Breccia M,Noguera NI,Diverio D,Finolezzi E,Pogliani EM,Di Bona E,Micalizzi C,Kropp M,Venditti A,Tafuri A,Mandelli F

更新日期：2004-10-01 00:00:00

abstract：:Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenging diagnosis after hematopoietic stem cell transplantation. Although endothelial injury represents the final common pathway of disease, the exact pathophysiology of TA-TMA remains unclear. Potential causes include infections, chemotherapy, ra...

journal_title：Blood

authors： Laskin BL,Goebel J,Davies SM,Jodele S

更新日期：2011-08-11 00:00:00

abstract：:Surprisingly, the role(s) of eosinophils in health and disease is often summarized by clinicians and basic research scientists as a pervasive consensus opinion first learned in medical/graduate school. Eosinophils are rare white blood cells whose activities are primarily destructive and are only relevant in parasitic ...

journal_title：Blood

authors： Jacobsen EA,Helmers RA,Lee JJ,Lee NA

更新日期：2012-11-08 00:00:00

abstract：:It has previously been shown that human granulocyte-macrophage colony-stimulating factor (GM-CSF) can be fused to a truncated diphtheria toxin (DT) to produce a recombinant fusion toxin that kills GM-CSF receptor-bearing cells. We now report that DT388-GM-CSF induces apoptosis and inhibition of colony formation in sem...

journal_title：Blood

authors： Frankel AE,Hall PD,Burbage C,Vesely J,Willingham M,Bhalla K,Kreitman RJ

更新日期：1997-11-01 00:00:00

abstract：:Pneumonia induced by Gram-negative bacteria is a common and serious disease associated with high morbidity and mortality. Elimination of bacterial pathogens relies on the recruitment and functions of neutrophils. The adhesion molecule L-selectin has recently been implicated in integrin activation in neutrophils (insid...

journal_title：Blood

authors： Cappenberg A,Margraf A,Thomas K,Bardel B,McCreedy DA,Van Marck V,Mellmann A,Lowell CA,Zarbock A

更新日期：2019-10-24 00:00:00

abstract：:Vascular endothelial-cadherin (VE-cadherin) is a calcium-dependent adhesive molecule, exclusively and constitutively expressed in endothelial cells. Analysis of the VE-cadherin promoter fused to a reporter gene in bovine aortic endothelial cells showed three major functional regions. The proximal region alone (-139, +...

journal_title：Blood

authors： Gory S,Vernet M,Laurent M,Dejana E,Dalmon J,Huber P

更新日期：1999-01-01 00:00:00

abstract：:Most patients with acute myeloid leukemia (AML) enter complete remission (CR) after treatment with chemotherapy, but a large number of them experience relapse with resistant disease. To identify genes that are associated with their prognoses, we analyzed gene expression in 54 pediatric patients with AML using an oligo...

journal_title：Blood

authors： Yagi T,Morimoto A,Eguchi M,Hibi S,Sako M,Ishii E,Mizutani S,Imashuku S,Ohki M,Ichikawa H

更新日期：2003-09-01 00:00:00

abstract：:Cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs) are synthetic ODNs with unmethylated DNA sequences that mimic viral and bacterial DNA and protect against infectious agents and tumor challenge. We show that CpG ODNs markedly accelerated graft-versus-host disease (GVHD) lethality by Toll-like receptor...

journal_title：Blood

authors： Taylor PA,Ehrhardt MJ,Lees CJ,Panoskaltsis-Mortari A,Krieg AM,Sharpe AH,Murphy WJ,Serody JS,Hemmi H,Akira S,Levy RB,Blazar BR

更新日期：2008-10-15 00:00:00

abstract：:Myelodysplastic syndromes (MDSs) are chronic and often progressive myeloid neoplasms associated with remarkable heterogeneity in the histomorphology and clinical course. Various somatic mutations are involved in the pathogenesis of MDS. Recently, mutations in a gene encoding a spliceosomal protein, SF3B1, were discove...

journal_title：Blood

authors： Makishima H,Visconte V,Sakaguchi H,Jankowska AM,Abu Kar S,Jerez A,Przychodzen B,Bupathi M,Guinta K,Afable MG,Sekeres MA,Padgett RA,Tiu RV,Maciejewski JP

更新日期：2012-04-05 00:00:00

abstract：:Factor IXAlabama is a variant factor IX molecule responsible for a clinically moderate form of hemophilia B. Twenty-five kilobases (kb) of the variant gene, including seven exons coding for the structural protein, were cloned and characterized. The restriction map and the arrangement of coding regions are identical to...

journal_title：Blood

authors： Davis LM,McGraw RA,Ware JL,Roberts HR,Stafford DW

更新日期：1987-01-01 00:00:00

abstract：:Chromosomal translocations involving the platelet-derived growth factor beta receptor (PDGFbetaR) gene have been reported in some patients with chronic myelomonocytic leukemia (CMML). The resultant fusion proteins have constitutive PDGFbetaR tyrosine kinase activity, but the partner genes previously reported (tel, Hun...

journal_title：Blood

authors： Magnusson MK,Meade KE,Brown KE,Arthur DC,Krueger LA,Barrett AJ,Dunbar CE

更新日期：2001-10-15 00:00:00

abstract：:In multiple myeloma, cytogenetic changes are important predictors of patient outcome. In this setting, the most important changes are deletion 17p, del(17p), and translocation of chromosomes 4 and 14, t(4;14), conferring a poor outcome. However, a certain degree of heterogeneity is observed in the survival of these hi...

journal_title：Blood

authors： Hebraud B,Magrangeas F,Cleynen A,Lauwers-Cances V,Chretien ML,Hulin C,Leleu X,Yon E,Marit G,Karlin L,Roussel M,Stoppa AM,Belhadj K,Voillat L,Garderet L,Macro M,Caillot D,Mohty M,Facon T,Moreau P,Attal M,Munshi N

更新日期：2015-03-26 00:00:00

abstract：:Understanding the molecular pathogenesis of lymphoma has led to paradigm-changing treatment opportunities. One example involves tailoring specific agents based on the cell of origin in aggressive lymphomas. Germinal center (GC)-derived diffuse large B-cell lymphoma (DLBCL) is known to be driven by an addiction to Bcl6...

journal_title：Blood

authors： Amengual JE,Clark-Garvey S,Kalac M,Scotto L,Marchi E,Neylon E,Johannet P,Wei Y,Zain J,O'Connor OA

更新日期：2013-09-19 00:00:00

abstract：:The HOXA9 homeoprotein exerts dramatic effects in hematopoiesis. Enforced expression of HOXA9 enhances proliferation of primitive blood cells, expands hematopoietic stem cells (HSCs), and leads to myeloid leukemia. Conversely, loss of HOXA9 inhibits proliferation and impairs HSC function. The pathways by which HOXA9 a...

journal_title：Blood

authors： Hu YL,Passegué E,Fong S,Largman C,Lawrence HJ

更新日期：2007-06-01 00:00:00

abstract：:The interaction between platelet receptor glycoprotein Ibα and the A1 domain of von Willebrand factor (VWF) mediates tethering/translocation of platelets to sites of vascular injury. Unexpectedly, we observed platelets translocating over A1A2A3 domains protein slower than on A1 domain at high shear stress. This observ...

journal_title：Blood

authors： Da Q,Behymer M,Correa JI,Vijayan KV,Cruz MA

更新日期：2014-04-24 00:00:00

abstract：:FLT3 is constitutively activated by internal tandem duplications (ITDs) in the juxtamembrane domain or by activation loop mutations in acute myeloid leukemia (AML). We tested the sensitivity of 8 activation loop mutations to the small molecule FLT3 inhibitor, MLN518. Each FLT3 activation loop mutant, including D835Y, ...

journal_title：Blood

authors： Clark JJ,Cools J,Curley DP,Yu JC,Lokker NA,Giese NA,Gilliland DG

更新日期：2004-11-01 00:00:00

abstract：:Recent data have implicated macrophage inflammatory protein-1alpha (MIP-1alpha) in multiple myeloma (MM)-associated osteolysis. However, it is unclear whether the chemokine's effects are direct, to enhance osteolysis, or indirect and mediated through a reduction in tumor burden, or both. It is also unclear whether MIP...

journal_title：Blood

authors： Oyajobi BO,Franchin G,Williams PJ,Pulkrabek D,Gupta A,Munoz S,Grubbs B,Zhao M,Chen D,Sherry B,Mundy GR

更新日期：2003-07-01 00:00:00

abstract：:Eosinophils are associated with type 2 immune responses to allergens and helminths. They release various proinflammatory mediators and toxic proteins on activation and are therefore considered proinflammatory effector cells. Eosinophilia is promoted by the cytokines interleukin (IL)-3, IL-5, and granulocyte macrophage...

journal_title：Blood

authors： Schwartz C,Willebrand R,Huber S,Rupec RA,Wu D,Locksley R,Voehringer D

更新日期：2015-06-18 00:00:00

abstract：:Conditioned medium derived from peripheral mononuclear low-density cells stimulated with phytohemagglutinin (PHA) supports the growth of noncommitted hematopoietic progenitors from marrow and peripheral blood cells. These immature progenitors (CFU-GEMM) can be identified in culture as multilineage hematopoietic coloni...

journal_title：Blood

authors： Kanz L,Löhr GW,Fauser AA

更新日期：1986-11-01 00:00:00

abstract：:Although receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) signaling has been shown to prolong the survival of mature dendritic cells (DCs), the association of RANKL pathway with Fas-mediated apoptosis is obscure. Here, we found that bone marrow-derived DCs (BMDCs) from the Fas-deficient strain MRL/lpr m...

journal_title：Blood

authors： Izawa T,Ishimaru N,Moriyama K,Kohashi M,Arakaki R,Hayashi Y

更新日期：2007-07-01 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is classically described to result from a dysregulation of the complement alternative pathway, leading to glomerular endothelial cell (EC) damage and thrombosis. However, recent findings in families with aHUS of mutations in the DGKE gene, which is not an integral component of...

journal_title：Blood

authors： Bruneau S,Néel M,Roumenina LT,Frimat M,Laurent L,Frémeaux-Bacchi V,Fakhouri F

更新日期：2015-02-05 00:00:00

abstract：:Protein Z is a vitamin K-dependent glycoprotein that plays a role in the regulation of coagulation. A nucleotide substitution of G by C in exon II of the protein Z gene, resulting in the replacement of Glu-30 with Gln (E30Q), and a G to A transition at the 79th nucleotide in intron F (IntF79G/A) were heterozygously id...

journal_title：Blood

authors： Souri M,Koseki-Kuno S,Iwata H,Kemkes-Matthes B,Ichinose A

更新日期：2005-04-15 00:00:00

abstract：:Short-chain fatty acids (SCFAs) and dimethyl sulfoxide (DMSO) induce adult erythroid differentiation in murine erythroleukemia (MEL) cells, but only SCFAs concurrently up-regulate expression from the endogenous embryonic globin gene epsilony. The epsilony promoter, linked to a reporter gene and stably transfected into...

journal_title：Blood

authors： Dempsey NJ,Ojalvo LS,Wu DW,Little JA

更新日期：2003-12-01 00:00:00

abstract：:Mechanisms underlying fetal hemoglobin (HbF) reactivation in stress erythropoiesis have not been fully elucidated. We suggested that a key role is played by kit ligand (KL). Because glucocorticoids (GCs) mediate stress erythropoiesis, we explored their capacity to potentiate the stimulatory effect of KL on HbF reactiv...

journal_title：Blood

authors： Gabbianelli M,Testa U,Massa A,Morsilli O,Saulle E,Sposi NM,Petrucci E,Mariani G,Peschle C

更新日期：2003-04-01 00:00:00

abstract：:The activation of murine dendritic cells by Toxoplasma gondii has recently been shown to depend on a parasite protein that signals through the chemokine receptor CCR5. Here we demonstrate that this molecule, cyclophilin-18 (C-18), is an inhibitor of HIV-1 cell fusion and infection with cell-free virus. T gondii C-18 e...

journal_title：Blood

authors： Golding H,Aliberti J,King LR,Manischewitz J,Andersen J,Valenzuela J,Landau NR,Sher A

更新日期：2003-11-01 00:00:00

abstract：:The effects of selectively depleting CD8+ cells from donor bone marrow were assessed in 36 patients receiving transplantation from an HLA-identical sibling as treatment for leukemia. Donor bone marrow underwent ex vivo treatment using anti-Leu-2 monoclonal antibody and complement. Patients received cyclosporine post-t...

journal_title：Blood

authors： Champlin R,Ho W,Gajewski J,Feig S,Burnison M,Holley G,Greenberg P,Lee K,Schmid I,Giorgi J

更新日期：1990-07-15 00:00:00

abstract：:The risk of development of CNS leukemia was investigated in 153 adults with acute lymphocytic leukemia (ALL) who received systemic combination chemotherapy without CNS prophylaxis. Overall, 31 patients (20%) developed CNS leukemia after a median of 6 months of therapy; the estimated 1-year incidence of CNS leukemia wa...

journal_title：Blood

authors： Kantarjian HM,Walters RS,Smith TL,Keating MJ,Barlogie B,McCredie KB,Freireich EJ

更新日期：1988-11-01 00:00:00