Serum proteins in prostatic cancer. II. Effect on in vitro cell-mediated immunologic responsiveness.

Abstract:

:The sera from patients with prostatic cancer have been observed to posses an unidentified factor capable of inhibiting the migration of leukocytes and the proliferative response to the nonspecific mitogen, phytohemagglutinin. Observation of inhibition of these two suggested in vitro correlates fo cell-mediated immunologic responsiveness emphasizes (1) the importance to the adjunctive diagnosis and prognosis of patients with malignancy of identifying the presence of abnormal serum proteins, and (2) the role of humoral inhibitory or "immunoregulatory" factors as potential abrogators of mechanisms of host resistance, for example, immunologic surveillance, and thus the degree to whcih the host may respond to his tumor.

journal_name

Urology

journal_title

Urology

authors

Ablin RJ,Guinan PD,Bruns GR,Sadoughi N,Bush IM

doi

10.1016/0090-4295(75)90586-5

subject

Has Abstract

pub_date

1975-07-01 00:00:00

pages

22-9

issue

1

eissn

0090-4295

issn

1527-9995

journal_volume

6

pub_type

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