Abstract:
:One of the primary antibacterial defense mechanisms of the bladder is the action of the luminal mucopolysaccharide layer against adsorption of inoculated bacteria. Previous studies have shown that local instillation of the mucopolysaccharide heparin can prevent bacterial adsorption on the bladder mucosa denuded of this "antiadherence factor." To determine whether this action was due to the mucopolysaccharide composition of heparin, or rather to its anticoagulant property, protamine sulfate (a basic protein with anticoagulant properties) was tested for antiadsorptive efficacy. Protamine offered no protection against bacterial adherence in the rabbit model. It appears that heparin's protective effect is unrelated to its action as an anticoagulant.
journal_name
Urologyjournal_title
Urologyauthors
Hanno PM,Fritz RW,Mulholland SG,Wein AJdoi
10.1016/0090-4295(81)90362-9subject
Has Abstractpub_date
1981-09-01 00:00:00pages
273-6issue
3eissn
0090-4295issn
1527-9995pii
0090-4295(81)90362-9journal_volume
18pub_type
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