Heparin--examination of its antibacterial adsorption properties.

Abstract:

:One of the primary antibacterial defense mechanisms of the bladder is the action of the luminal mucopolysaccharide layer against adsorption of inoculated bacteria. Previous studies have shown that local instillation of the mucopolysaccharide heparin can prevent bacterial adsorption on the bladder mucosa denuded of this "antiadherence factor." To determine whether this action was due to the mucopolysaccharide composition of heparin, or rather to its anticoagulant property, protamine sulfate (a basic protein with anticoagulant properties) was tested for antiadsorptive efficacy. Protamine offered no protection against bacterial adherence in the rabbit model. It appears that heparin's protective effect is unrelated to its action as an anticoagulant.

journal_name

Urology

journal_title

Urology

authors

Hanno PM,Fritz RW,Mulholland SG,Wein AJ

doi

10.1016/0090-4295(81)90362-9

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

273-6

issue

3

eissn

0090-4295

issn

1527-9995

pii

0090-4295(81)90362-9

journal_volume

18

pub_type

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