Antagonism of striatal muscarinic receptors inhibiting dopamine D1 receptor-stimulated adenylyl cyclase activity by cholinoceptor antagonist used to treat Parkinson's disease.

abstract：:1. The potassium-sparing diuretic, amiloride, has been shown to inhibit the Na/Ca exchange system in various preparations. The effects of this drug have been investigated on the contractions of guinea-pig aortic strips elicited by reduction of external K, by addition of ouabain and by removal of external Na. 2. Amilor...

journal_title：British journal of pharmacology

authors： Bova S,Cargnelli G,Luciani S

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Sepsis is a systemic inflammatory response accompanied by excessive production of inflammatory cytokines and cardiovascular dysfunction. Importantly, macrophage-derived pro-inflammatory agents play a key role in cardiovascular impairment in sepsis. Here we have investigated the effects of trimeta...

journal_title：British journal of pharmacology

authors： Chen J,Lai J,Yang L,Ruan G,Chaugai S,Ning Q,Chen C,Wang DW

更新日期：2016-02-01 00:00:00

abstract：:1. The effects of lifarizine (RS-87476) on intracellular Ca2+ rises and the release of glutamate from rat cerebrocortical synaptosomes depolarized with 30 mM KCl were investigated by use of entrapped fura 2 and exogenous glutamate dehydrogenase. 2. Prior (1 min) addition of lifarizine decreased 30 mM KCl-induced total...

journal_title：British journal of pharmacology

authors： Budd DC,May GR,Nicholls DG,McCormack JG

更新日期：1996-05-01 00:00:00

abstract：:1 The actions of parathyroid hormone (PTH) are antagonized in vitro by the peptide [Nle-8, Nle-18, Tyr-34]-bPTH-(3-34)amide, an analogue of PTH. In this paper, the actions of the inhibitory peptide were investigated in vivo. 2 Native parathyroid hormone (bPTH-(1-84)), administered i.v. (0.17-1.51 nmol in volume of 0.3...

journal_title：British journal of pharmacology

authors： Gray DA,Parsons JA,Potts JT Jr,Rosenblatt M,Stevenson RW

更新日期：1982-06-01 00:00:00

abstract：:1 The venom of the green mamba, Dendroaspis angusticeps, was tested for effects on neuromuscular transmission and skeletal muscle contractility in isolated phrenic nerve-hemidiaphragm preparations of the rat and mouse, chick biventer cervicis muscle preparations and in aneural cultures of embryonic chick skeletal musc...

journal_title：British journal of pharmacology

authors： Barrett JC,Harvey AL

更新日期：1979-10-01 00:00:00

abstract：:1. Relaxing effect of loop diuretics, piretanide and furosemide in comparison with acetylcholine (ACh) was investigated in guinea-pig isolated mesenteric resistance arteries. 2. Concentration-response curves to ACh (0.001 - 10 microM) and diuretics (0.0001 - 1 microM) were constructed in noradrenaline (10 - 30 microM)...

journal_title：British journal of pharmacology

authors： Pourageaud F,Bappel-Gozalbes C,Marthan R,Freslon JL

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Fibroblast-to-myofibroblast differentiation is associated with scarring, an important issue in corneal surgery. Moxifloxacin (MOX), commonly applied to prevent post-operative infection, would benefit more if it modifies fibroblast-to-myofibroblast differentiation other than antimicrobial activity...

journal_title：British journal of pharmacology

authors： Chen TC,Chang SW,Wang TY

更新日期：2013-03-01 00:00:00

abstract：:1. The mechanisms involved in tachykinin-induced oedema were investigated in rat skin and interactions between the tachykinins and calcitonin gene-related peptide (CGRP) were studied. 2. Intradermal injections of the tachykinins, substance P, neurokinin A and neurokinin B, stimulated local oedema formation which was i...

journal_title：British journal of pharmacology

authors： Brain SD,Williams TJ

更新日期：1989-05-01 00:00:00

abstract：LINKED ARTICLES:This article is part of a themed section on Nitric Oxide 20 Years from the 1998 Nobel Prize. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.2/issuetoc. ...

journal_title：British journal of pharmacology

authors： Ignarro LJ

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Iridoid glycosides containing the double bond scaffold of cyclopentapyran are reversible and orthosteric agonists of glucagon-like peptide-1 (GLP-1) receptors and exert anti-nociceptive and neuroprotective actions. Morroniside, derived from the medicinal herb Cornus officinalis, is an atypical se...

journal_title：British journal of pharmacology

authors： Xu M,Wu HY,Liu H,Gong N,Wang YR,Wang YX

更新日期：2017-04-01 00:00:00

abstract：:1. The effect of adenosine triphosphate (ATP) and its stable analogues, alpha, beta-methylene-ATP and beta, gamma-methylene-ATP, on the efferent function of capsaicin-sensitive non-adrenergic, non-cholinergic (NANC) nerves was tested in guinea-pig isolated atria. 2. Transmural nerve stimulation of atria isolated from ...

journal_title：British journal of pharmacology

authors： Rubino A,Amerini S,Ledda F,Mantelli L

更新日期：1992-03-01 00:00:00

abstract：:The binding of [3H]-iloprost (ZK36374) to NCB-20 membranes revealed a single population of high affinity receptors (KD = 9.55 nM, Bmax = 431 fmol mg-1 protein) and a low affinity, non-saturable binding component. Desensitization of prostacyclin-responsiveness of NCB-20 cells is induced by culture in the presence of th...

journal_title：British journal of pharmacology

authors： Leigh PJ,MacDermot J

更新日期：1985-05-01 00:00:00

abstract：:The role of putative neurotransmitters of the central nervous system in the central gastric antisecretory effect of prostaglandin E2 (PGE2) was investigated in pylorus-ligated rats. Pretreatment of the rats with an intracerebroventricular (i.c.v.) injection of 6-hydroxydopamine (6-OHDA) prevented the antisecretory eff...

journal_title：British journal of pharmacology

authors： Puurunen J

更新日期：1985-05-01 00:00:00

abstract：:1 The rectum isolated from the fowl was perfused with Tyrode solution via the caudal mesenteric artery. Noradrenaline and adrenaline were biologically or fluorimetrically assayed in perfusates collected before and during stimulation of Remak's nerve or of the periarterial nerves.2 Perfusates collected during nerve sti...

journal_title：British journal of pharmacology

authors： Komori S,Ohashi H,Okada T,Takewaki T

更新日期：1979-02-01 00:00:00

abstract：:1. Sabcomeline (SB-202026, 0.03 mg kg(-1), p.o.), a potent and functionally selective M1 receptor partial agonist, caused a statistically significant improvement in the performance of a visual object discrimination task by marmosets. No such improvement was seen after RS86 (0.1 mg kg(-1), p.o.). 2. Initial learning, w...

journal_title：British journal of pharmacology

authors： Harries MH,Samson NA,Cilia J,Hunter AJ

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Agonists of the M(2) muscarinic acetylcholine receptor (mAChR) increase mRNA for this receptor and mRNA for endothelial and neuronal isoforms of NO synthase (eNOS or nNOS). Here we examine the different signalling pathways involved in such events in rat cardiac atria. EXPERIMENTAL APPROACH:In is...

journal_title：British journal of pharmacology

authors： Ganzinelli S,Joensen L,Borda E,Bernabeo G,Sterin-Borda L

更新日期：2007-05-01 00:00:00

abstract：:1. We investigated the cytoprotective effect of low-dose nitric oxide (NO) on NO-induced cell death in mouse macrophage-like cell line RAW264. 2. Sodium nitroprusside (SNP), an NO donor, at a high concentration (4 mM) released cytochrome c from mitochondria and induced death in RAW264 cells. Acetyl-L-aspartyl-L-glutam...

journal_title：British journal of pharmacology

authors： Yoshioka Y,Yamamuro A,Maeda S

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Selective cannabinoid CB2 receptor agonists have demonstrated analgesic activity across multiple preclinical pain models. AM1241 is an indole derivative that exhibits high affinity and selectivity for the CB2 binding site and broad spectrum analgesic activity in rodent models, but is not an antag...

journal_title：British journal of pharmacology

authors： Yao BB,Hsieh GC,Frost JM,Fan Y,Garrison TR,Daza AV,Grayson GK,Zhu CZ,Pai M,Chandran P,Salyers AK,Wensink EJ,Honore P,Sullivan JP,Dart MJ,Meyer MD

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Gut microbiota plays an important role in type 2 diabetes mellitus (T2DM) progression. From our previous work N-(4-Hydroxyphenethyl)-3-mercapto-2-methylpropanamide (HMPA) is a potential T2DM drug. We evaluated the effect of HMPA on gut microbiota and studied the molecular mechanism underlying HMP...

journal_title：British journal of pharmacology

authors： Liu H,Qin Y,Li K,Li M,Yang J,Tao H,Tang Y,Yang L,Chen S,Liu Y,Yang C,Gao W,Sun T

更新日期：2020-12-07 00:00:00

abstract：:1 Contractions of the cat nictitating membrane were elicited on stimulation of the internal carotid nerve, and the effects were studied of desipramine and two inhibitors of catechol-O-methyltransferase, U-0521 and pyrogallol, on the subsequent relaxation of the muscle. 2 The relaxation of the nictitating membrane occu...

journal_title：British journal of pharmacology

authors： Eccles R,Maclean AG

更新日期：1978-04-01 00:00:00

abstract：:There is a long-known hyper-responsiveness of vascular adrenergic transmission in the spontaneously hypertensive rat (SHR) that is uncovered specifically in the presence of cocaine and attributed to blockade of the neuronal monoamine transporter. We have now used the rat anococcygeus muscle to investigate whether this...

journal_title：British journal of pharmacology

authors： Jimenez-Altayo F,Giraldo J,McGrath JC,Vila E

更新日期：2003-10-01 00:00:00

abstract：:1. Arachidonic acid caused larger contractions to indomethacin-tested guinea-pig trachea than in control tracheae. 2. No change in contractions was obtained in tracheae treated with 5,8, 11, 14, eicosatetraynoic acid (ETYA 10 micro M). 3. ETYA (100 micro M) blocked the effect of indomethacin on arachidonic acid-induce...

journal_title：British journal of pharmacology

authors： Mitchell HW

更新日期：1982-08-01 00:00:00

abstract：:1 The recently discovered benzodiazepine receptor exists in high concentration in the cerebral cortex. We have, therefore, examined the effects of diazepam and chlordiazepoxide on cortical neurone responses to excitatory and inhibitory amino acids and acetylcholine, in the cortex of rats anaesthetized with urethane.2 ...

journal_title：British journal of pharmacology

authors： Assumpção JA,Bernardi N,Brown J,Stone TW

更新日期：1979-12-01 00:00:00

abstract：:1. In anaesthetized patients under controlled respiration, samples of lumbar cerebrospinal fluid were withdrawn 15 and 60 min after an intravenous injection of 30 mg tubocurarine. When tested on the frog rectus muscle preparation contracted by acetylcholine, they exerted curare-like activity which corresponded to betw...

journal_title：British journal of pharmacology

authors： Devasankaraiah G,Haranath PS,Krishnamurty A

更新日期：1973-04-01 00:00:00

abstract：:Knock-out (KO) mouse technology has given pharmacologists a powerful tool to study function in the absence of selective antagonists or inhibitors. Such KO technology can confirm predicted function, serendipitously reveal unrecognized function, or help define the mode of action of a drug. In this issue, Liles et al. de...

journal_title：British journal of pharmacology

authors： Docherty JR

更新日期：2007-01-01 00:00:00

abstract：:Peroxisome proliferator activated receptors (PPAR)s are nuclear transcription factors of the steroid receptor super-family. One member, PPARgamma, a critical transcription factor in adipogenesis, is expressed in ECV304 cells, and when activated participates in the induction of cell death by apoptosis. Here we describe...

journal_title：British journal of pharmacology

authors： Bishop-Bailey D,Hla T,Warner TD

更新日期：2000-10-01 00:00:00

abstract：:1. The effect of intravenous administration of dexamphetamine [+)-Amp) on rat pupil diameter was investigated. In all experiments, the vagosympathetic trunks were sectioned bilaterally at the cervical level. 2. In rats anaesthetized with urethane, (+)-Amp (0.1-0.3 mg kg-1, i.v.) produced a dose-related increase in pup...

journal_title：British journal of pharmacology

authors： Hey JA,Ito T,Koss MC

更新日期：1989-01-01 00:00:00

abstract：:Free radicals as well as the AT1 receptor are involved in the pathogenesis of cardiovascular disease. Both the intracellular mechanisms of AT1 receptor regulation and the effect of free radicals on AT1 receptor expression are currently unknown. This study investigates the role of free radicals in the modulation of AT1...

journal_title：British journal of pharmacology

authors： Nickenig G,Strehlow K,Bäumer AT,Baudler S,Wassmann S,Sauer H,Böhm M

更新日期：2000-10-01 00:00:00

abstract：:1. Diadenosine tetraphosphate (Ap4A) a dinucleotide stored and released from rat brain synaptic terminals presents two types of affinity binding sites in synaptosomes. When [3H]-Ap4A was used for binding studies a Kd value of 0.10 +/- 0.014 nM and a Bmax value of 16.6 +/- 1.2 fmol mg-1 protein were obtained for the hi...

journal_title：British journal of pharmacology

authors： Pintor J,Díaz-Rey MA,Miras-Portugal MT

更新日期：1993-04-01 00:00:00

abstract：:Fresh human erythrocytes were washed and incubated at 37 degrees C in physiological saline buffered with Tris, containing calcium and either neuraminidase or trypsin or both enzymes together. Each enzyme alone, as well as both together, released similar amounts of sialic acids without haemolysis, apparently therefore ...

journal_title：British journal of pharmacology

authors： Born GV,Housley GM

更新日期：1983-06-01 00:00:00