Abstract:
:Using the expression strategies described here, we have demonstrated a model system whereby the sequential signaling events involved in cell proliferation and subsequent transformation regulated by G alpha 12 can be investigated. The model system presented here can also be used to study the temporal interrelationships between small GTPases, kinases, and other signaling proteins involved in G alpha 12-signaling pathways. Further analyses using this model system and the strategies presented here should provide valuable clues in defining the signaling network regulated by G alpha 12 in stimulating cell proliferation and oncogenic transformation.
journal_name
Methods Enzymoljournal_title
Methods in enzymologyauthors
Dermott JM,Dhanasekaran Ndoi
10.1016/s0076-6879(02)44722-2subject
Has Abstractpub_date
2002-01-01 00:00:00pages
298-309eissn
0076-6879issn
1557-7988journal_volume
344pub_type
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