Abstract:
:The additional time to complete a three-period two-treatment (3P2T) cross-over trial may cause a greater number of patient dropouts than with a two-period trial. This paper develops maximum likelihood (ML), single imputation and multiple imputation missing data analysis methods for the 3P2T cross-over designs. We use a simulation study to compare and contrast these methods with one another and with the benchmark method of missing data analysis for cross-over trials, the complete case (CC) method. Data patterns examined include those where the missingness differs between the drug types and depends on the unobserved data. Depending on the missing data mechanism and the rate of missingness of the data, one can realize substantial improvements in information recovery by using data from the partially completed patients. We recommend these approaches for the 3P2T cross-over designs.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Richardson BA,Flack VFdoi
10.1002/(SICI)1097-0258(19960130)15:2<127::AID-SIMsubject
Has Abstractpub_date
1996-01-30 00:00:00pages
127-43issue
2eissn
0277-6715issn
1097-0258pii
10.1002/(SICI)1097-0258(19960130)15:2<127::AID-SIMjournal_volume
15pub_type
杂志文章abstract::A new method is proposed for the surveillance of Down's syndrome among newborn. Despite the strong dependence of overall risk of Down's syndrome on maternal age, it has been suggested that an environmentally induced increase in risk may be additive over all maternal ages. The surveillance method introduced here is spe...
journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:1993-01-15 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:1996-12-15 00:00:00
abstract::Many extensions of survival models based on the Cox proportional hazards approach have been proposed to handle clustered or multiple event data. Of particular note are five Cox-based models for recurrent event data: Andersen and Gill (AG); Wei, Lin and Weissfeld (WLW); Prentice, Williams and Peterson, total time (PWP-...
journal_title:Statistics in medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-01-15 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:2013-03-30 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:2012-12-10 00:00:00
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pub_type: 杂志文章
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更新日期:1999-02-28 00:00:00
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更新日期:2004-04-30 00:00:00
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pub_type: 杂志文章
doi:10.1002/sim.6301
更新日期:2014-12-10 00:00:00
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更新日期:2000-05-30 00:00:00
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pub_type: 杂志文章
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更新日期:2008-01-30 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.3915
更新日期:2010-08-15 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.2653
更新日期:2007-03-30 00:00:00
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pub_type: 杂志文章
doi:10.1002/sim.8351
更新日期:2019-11-20 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780080511
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780111311
更新日期:1992-09-30 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(19990330)18:6<727::aid-sim
更新日期:1999-03-30 00:00:00
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pub_type: 杂志文章
doi:10.1002/sim.3074
更新日期:2008-05-30 00:00:00
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pub_type: 杂志文章
doi:10.1002/sim.8056
更新日期:2019-04-30 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780090707
更新日期:1990-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2003-02-28 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/sim.4780130511
更新日期:1994-03-15 00:00:00
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pub_type: 杂志文章
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更新日期:2015-07-10 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0258(20000315)19:5<697::aid-sim
更新日期:2000-03-15 00:00:00
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pub_type: 杂志文章
doi:10.1002/sim.7554
更新日期:2018-04-15 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:2020-11-20 00:00:00
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journal_title:Statistics in medicine
pub_type: 杂志文章
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更新日期:2004-02-15 00:00:00
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journal_title:Statistics in medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-12-30 00:00:00