Abstract:
:Although statistical methodology is well-developed for comparing diagnostic tests in terms of their sensitivity and specificity, comparative inference about predictive values is not. In this paper, we consider the analysis of studies comparing operating characteristics of two diagnostic tests that are measured on all subjects and have test outcomes from multiple sites with varying number of sites among subjects. We have developed a new approach for comparing sensitivity, specificity, positive predictive value, and negative predictive value with simple variance calculation and, in particular, focus on comparing tests using difference of positive and negative predictive values. Simulation studies are conducted to show the performance of our approach. We analyze real data on patients with lung cancer, based on their diagnostic tests, to illustrate the methodology.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Kwak M,Um SW,Jung SHdoi
10.1002/sim.6485subject
Has Abstractpub_date
2015-07-10 00:00:00pages
2325-33issue
15eissn
0277-6715issn
1097-0258journal_volume
34pub_type
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