Diffusion and perfusion MRI for the localisation of epileptogenic foci in drug-resistant epilepsy.

Abstract:

:Drug-resistant epilepsy is an important clinical challenge, both diagnostically and therapeutically. More and more surgical options are being considered, but precise presurgical assessment is necessary. We prospectively studied eight patients with drug-resistant epilepsy, who underwent clinical examination, single photon emission computed tomography (SPECT) and interictal MRI, including diffusion- and perfusion-weighted echoplanar sequences. Lesions suspected on SPECT of being epileptogenic showed mild hypoperfusion, while the diffusion-weighted MRI (DWI) revealed increased apparent diffusion coefficients relative to the other side. However, these abnormalities were not visible on the corresponding maps. We showed that DWI and perfusion-weighted MRI could be used confirm the characteristics and site of an epileptogenic area in patients with drug-resistant epilepsy.

journal_name

Neuroradiology

journal_title

Neuroradiology

authors

Heiniger P,el-Koussy M,Schindler K,Lövblad KO,Kiefer C,Oswald H,Wissmeyer M,Mariani L,Donati F,Schroth G,Weder B

doi

10.1007/s00234-002-0785-z

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

475-80

issue

6

eissn

0028-3940

issn

1432-1920

journal_volume

44

pub_type

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