Contrast-enhanced FLAIR in the early diagnosis of infectious meningitis.

Abstract:

:We investigated the accuracy of MRI in the early diagnosis of infectious meningitis with emphasis on the value of gadolinium-enhanced fluid-attenuated inversion recovery (FLAIR) sequence. Twenty-seven patients with clinical suspicion of infectious meningitis were included. MRI was performed within 3 h of clinical evaluation. For all patients, T1-weighted spin-echo, dual-echo T2-weighted fast-spin-echo and FLAIR sequences were performed, followed by gadolinium-enhanced T1-weighted spin-echo and FLAIR sequences. Final diagnosis was based on the clinical findings and the analysis of cerebrospinal fluid, obtained by lumbar puncture after the MRI. Infectious meningitis was confirmed in 12 patients. In all of these patients of the plain studies, FLAIR was positive in only four patients. MRI gadolinium-enhanced FLAIR showed abnormal meningeal enhancement in all 12 patients, while gadolinium-enhanced T1-weighted spin-echo was positive only in six cases. There were no false-positive or false-negative results. It is concluded that MRI could have an important role in the early screening for infectious meningitis, provided a gadolinium-enhanced FLAIR sequence is used.

journal_name

Neuroradiology

journal_title

Neuroradiology

authors

Splendiani A,Puglielli E,De Amicis R,Necozione S,Masciocchi C,Gallucci M

doi

10.1007/s00234-005-1383-7

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

591-8

issue

8

eissn

0028-3940

issn

1432-1920

journal_volume

47

pub_type

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