Endothelin-1 expression and alterations of cerebral microcirculation after experimental subarachnoid hemorrhage.

Abstract:

INTRODUCTION:Cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) often leads to poor outcomes in SAH patients. Overexpression of endothelin-1 (ET-1) could contribute to the development of CVS. The purpose of this study was to investigate cerebral microcirculation by whole-brain perfusion CT scan and ET-1 expression following SAH. METHODS:SAH was induced in rabbits. Cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), and mean transit time (MTT) were measured with CT perfusion techniques at days 1, 4, 7, and 14 following SAH. Expression of ET-1 was determined by ELISA accordingly. Histological sections of the brain tissue were also examined. RESULTS:Whole-brain perfusion showed that CBV and TTP increased at day 4 and maintained elevated rate until day 14. MTT increased at day 4, peaked at day 7, and then decreased at day 14. CBV of the occipital lobe was greater than that in the frontal and parietal lobes at day 4. CBF of the occipital lobe increased significantly compared to that of other lobes at day 7. ET-1 expression in the SAH group was significantly greater than that in the control at various time points. Moreover, ET-1 levels were positively correlated with MTT value. CONCLUSION:CTP detects changes in cerebral microcirculation following SAH. Microcirculation of each lobe was different and could be quantified to identify high-risk areas of cerebral ischemia. ET-1 expression was significantly increased and was correlated with MTT as well, suggesting that ET-1 influences cerebral microcirculation following SAH.

journal_name

Neuroradiology

journal_title

Neuroradiology

authors

Lei Q,Li S,Zheng R,Xu K,Li S

doi

10.1007/s00234-014-1435-y

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

63-70

issue

1

eissn

0028-3940

issn

1432-1920

journal_volume

57

pub_type

杂志文章
  • Normal CT anatomy of the spine. Anatomo-radiological correlations.

    abstract::To analyse the anatomo-radiological correlation of the spine and spinal cord, 22 formalized, frozen anatomical specimens corresponding to different regions of the spinal column (8 cervical, 5 dorsal, and 9 lumbar) were studied by CT scans on axial, sagittal and coronal planes and by contact radiography after they were...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00344577

    authors: Quiroga O,Matozzi F,Beranger M,Nazarian S,Gambarelli J,Salamon G

    更新日期:1982-01-01 00:00:00

  • Cerebral venous angioma: computerized tomography and angiographic diagnosis.

    abstract::Four cases of cerebral venous angioma were studied by both CT and angiography. All cases showed similar angiographic findings: a normal arterial phase and a local network of small veins that converged centrally into a single large draining vein. However, CT showed nodular areas of high density in three cases, and a cu...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00395279

    authors: Maehara T,Tasaka A

    更新日期:1978-01-01 00:00:00

  • Imaging of calvarial eosinophil granuloma.

    abstract::We reviewed the imaging of four pathologically proven calvarial eosinophil granulomas. The diameter of the lesions ranged from 13 to 40 mm; three were biconvex, but the other had a collar-stud appearance. Two lesions were in the frontal and two in the parietal bone. On bone-window CT, a bevelled edge was seen in three...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s002340050831

    authors: Okamoto K,Ito J,Furusawa T,Sakai K,Tokiguchi S

    更新日期:1999-10-01 00:00:00

  • A case of spinal paraganglioma.

    abstract::The neuroradiologic finding of a paraganglioma in the vertebral canal is described here for the first time. These tumors occur more frequently than was previously presumed. Similarities with paragangliomas in the craniocervical region are apparent on angiograms. We consider angiography to be indicated when, in associa...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00344491

    authors: Solymosi L,Ferbert A

    更新日期:1985-01-01 00:00:00

  • Intraspinal epidermoid cyst: diffusion-weighted MRI.

    abstract::We report a 7-year-old boy who presented with two-month history of worsening low back and right leg pain. Conventional MR images demonstrated a poorly outlined intradural mass recognized by the displacement of the conus medullaris and the nerve roots of the cauda equina at the L2-3 level. The signal intensity of the l...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s002340000526

    authors: Teksam M,Casey SO,Michel E,Benson M,Truwit CL

    更新日期:2001-07-01 00:00:00

  • Relationships between portions of the third and fourth ventricles. An aid to stereotactic accuracy for posterior fossa stereotaxy.

    abstract::The relationships between the third and fourth ventricles have been studied by examination of the angles formed by third and fourth ventricular projections. These have been subjected to statistical analysis and have proved useful for posterior fossa stereotactic surgery. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00327527

    authors: Hitchcock E,Oppitz P,Donaldson AA

    更新日期:1978-08-18 00:00:00

  • Transcutaneous angioplasty of vertebral artery atheromatous ostial stricture.

    abstract::The authors report experience of intravascular angioplasty of atheromatous ostial strictures of the vertebral artery in 24 patients. After reviewing the technique, they outline the indications provided through Doppler velocimetric data. The results seem to be encouraging as symptoms disappeared completely in 21 patien...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00344498

    authors: Courtheoux P,Tournade A,Theron J,Henriet JP,Maiza D,Derlon JM,Pelouze G,Evrard C

    更新日期:1985-01-01 00:00:00

  • Extraspinal abnormalities identified on lumbar spine CT.

    abstract::Retrospective review of 1517 lumbar CT examinations revealed extraspinal pathology in 22 (1.45%). Retroperitoneal tumors and lymphadenopathy as well as vascular, urinary tract and gynecologic abnormalities were identified. This study demonstrates the need to carefully evaluate the visualized portions of the abdomen an...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00341767

    authors: Frager DH,Elkin CM,Kansler F,Mendelsohn SL,Leeds NE

    更新日期:1986-01-01 00:00:00

  • L5 radicular pain related to lumbar extradural gas-containing pseudocyst. Role of CT-guided aspiration.

    abstract::L5 radicular pain related to an epidural gas-containing pseudocyst is described in a 62-year-old female. Transient resolution of radicular pain was observed after CT-guided gas aspiration. Recurrent radicular pain led to surgical treatment; after operation the radicular pain disappeared. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00340142

    authors: Bosser V,Dietemann JL,Warter JM,Granel de Solignac M,Beaujeux R,Buchheit F

    更新日期:1990-01-01 00:00:00

  • Spinal intradural extramedullary cavernous hemangioma.

    abstract::Spinal intradural extramedullary cavernous hemangiomas are very rare. Mixed intensities on T1- andT2-weighted images due to repeated hemorrhages and poor to absent contrast-enhancement are the most common imaging features of the disease allowing accurate differentiation from the far more frequent meningiomas and schwa...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-018-2073-6

    authors: Pétillon P,Wilms G,Raftopoulos C,Duprez T

    更新日期:2018-10-01 00:00:00

  • Factors predicting retreatment and residual aneurysms at 1 year after endovascular coiling for ruptured cerebral aneurysms: Prospective Registry of Subarachnoid Aneurysms Treatment (PRESAT) in Japan.

    abstract:INTRODUCTION:Endovascular treatment of cerebral aneurysms includes follow-up imaging to identify aneurysms that may need retreatment. The aim of this study was to determine predictors of incomplete aneurysm occlusion at 1 year after endovascular coiling for ruptured cerebral aneurysms. METHODS:In 129 patients of the P...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-011-0945-0

    authors: Taki W,PRESAT group.,Sakai N,Suzuki H

    更新日期:2012-06-01 00:00:00

  • Unusual migration of a foreign body from the gut to a vertebral body.

    abstract::We report a unique case in which a needle was accidentally swallowed and migrated into the vertebral body. Plain films and CT of the spine revealed fragmented, linear, metallic-density material in the L3 vertebral body. The possible mechanisms of the migration are discussed. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s002340050663

    authors: Ozsunar Y,Tali ET,Kilic K

    更新日期:1998-10-01 00:00:00

  • Endovascular treatment in patients with carotid artery dissection and intracranial occlusion: a systematic review.

    abstract:PURPOSE:Recently, multiple randomised controlled trials showed efficacy of endovascular treatment over traditional care in patients with acute ischemic stroke due to an intracranial anterior circulation occlusion. Internal carotid artery (ICA) dissection with a concomitant intracranial occlusion is a rare but important...

    journal_title:Neuroradiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00234-017-1850-y

    authors: Hoving JW,Marquering HA,Majoie CBLM

    更新日期:2017-07-01 00:00:00

  • Pure sensory stroke resulting from thalamic haemorrhage.

    abstract::Pure sensory stroke has not previously been reported with thalamic haemorrhage and had indeed been considered to exclude cerebral haemorrhage. We describe a case of thalamic haemorrhage causing a pure sensory stroke and propose that we should bear in mind the possibility of haemorrhage in such cases. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00596336

    authors: Abe K,Yorifuji S,Nishikawa Y

    更新日期:1992-01-01 00:00:00

  • CT studies in patients operated with stereotaxic thalamotomies.

    abstract::CT has been used in controlling stereotaxic thalamotomies in patients with movement disorders. The results obtained in 12 such patients, with early and delayed scans, are presented. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00395361

    authors: Passerini A,Broggi G,Giorgi C,Savoiardo M

    更新日期:1978-01-01 00:00:00

  • T1 Gd-enhanced compared with CISS sequences in retinoblastoma: superiority of T1 sequences in evaluation of tumour extension.

    abstract:BACKGROUND:As adequate therapy for retinoblastoma in young children depends on infiltration of extra-retinal structures, diagnostic modalities play an essential role. METHODS:In this widely extended study, 80 children with retinoblastoma were studied with MRI (standard fat-suppressed Gd-enhanced T1, T2 thin-slice sequ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-004-1316-x

    authors: Gizewski ER,Wanke I,Jurklies C,Güngör AR,Forsting M

    更新日期:2005-01-01 00:00:00

  • CT scanning for the diagnosis of the cerebrellar and spinal lesions of von Hippel-Lindau's disease.

    abstract::The CT features of cerebellar lesions with von Hippel-Lindau's disease are analyzed. The use of CT scanning for associated spinal hemangioblastomas is discussed in the light of a case with a low cervical lesion. The role of computed tomography in the neuroradiological investigations is discussed. ...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00418622

    authors: Balériaux-Waha D,Retif J,Noterman J,Terwinghe G,Mortelmans LL,Dupont MG,Jeanmart L

    更新日期:1978-02-17 00:00:00

  • Symptomatic cerebrospinal fluid dissemination of cerebral glioblastoma. Computed tomographic findings in 11 cases.

    abstract::Computed tomography (CT) findings in eleven patients with symptomatic cerebrospinal fluid (CSF) dissemination from cerebral glioblastoma were analyzed and, in seven cases subsequently autopsied, they were compared with histological observations. Each patient had multiple CT abnormalities including periventricular enha...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00588565

    authors: Onda K,Tanaka R,Takahashi H,Takeda N,Ikuta F

    更新日期:1990-01-01 00:00:00

  • Treatment of acute ischemic stroke: feasibility of primary or secondary use of a self-expanding stent (Neuroform) during local intra-arterial thrombolysis.

    abstract:INTRODUCTION:We evaluated the feasibility of employing a self-expanding stent (Neuroform) in treatment of acute cerebral ischemia and compared the results of primary and secondary stenting. METHODS:We analyzed the treatment results of 14 acute ischemic stroke patients (11 men and three women; median age, 65 years) who...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-010-0813-3

    authors: Kim SM,Lee DH,Kwon SU,Choi CG,Kim SJ,Suh DC

    更新日期:2012-01-01 00:00:00

  • Angioarchitecture associated with haemorrhage in cerebral arteriovenous malformations: a prognostic statistical model.

    abstract::The overall haemorrhagic risk of a cerebral arteriovenous malformation (cAVM) is 2-4% per year. However, the individual risk of haemorrhage has never been determined. This study was undertaken to assess the haemorrhage risk of an individual cAVM. Neuroangiographic findings of 160 cAVM were analysed retrospectively, lo...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s002340050367

    authors: Nataf F,Meder JF,Roux FX,Blustajn J,Merienne L,Merland JJ,Schlienger M,Chodkiewicz JP

    更新日期:1997-01-01 00:00:00

  • Non-odontogenic tumors of the facial bones in children and adolescents: role of multiparametric imaging.

    abstract::Tumors of the pediatric facial skeleton represent a major challenge in clinical practice because they can lead to functional impairment, facial deformation, and long-term disfigurement. Their treatment often requires a multidisciplinary approach, and radiologists play a pivotal role in the diagnosis and management of ...

    journal_title:Neuroradiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00234-017-1798-y

    authors: Becker M,Stefanelli S,Rougemont AL,Poletti PA,Merlini L

    更新日期:2017-04-01 00:00:00

  • MR findings in leukodystrophy.

    abstract::Up to 5 years ago, the radiological diagnosis of leukodystrophy was based on computed tomography (CT). More recently, magnetic resonance imaging (MRI) has been used to study pathology of the white matter with great success. The abnormalities in eight patients with different types of leukodystrophy are described, using...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00587829

    authors: Demaerel P,Faubert C,Wilms G,Casaer P,Piepgras U,Baert AL

    更新日期:1991-01-01 00:00:00

  • Primary CNS lymphoma in the spinal cord: clinical manifestations may precede MRI detectability.

    abstract::We report a 36-year-old woman whose first MRI after developing symptoms of cervical nerve root irritation was normal. Eight months later, after progression to tetraparesis and demonstration of an extensive contrast-enhancing intramedullary lesion giving high signal on T2-weighted images, the diagnosis of lymphoblastic...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s002340100701

    authors: Herrlinger U,Weller M,Küker W

    更新日期:2002-03-01 00:00:00

  • Evaluation of small hypothalamic hamartomas with 3D constructive interference in steady state (CISS) sequence.

    abstract::Hypothalamic hamartomas are relatively rare, non-neoplastic congenital malformations. With conventional MR images alone, small hypothalamic hamartomas may be difficult to diagnose because of artifacts from cerebrospinal fluid. We present the usefulness of three-dimensional constructive interference in steady state seq...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-005-1340-5

    authors: Yamura M,Hirai T,Korogi Y,Kitajima M,Hayashida Y,Ikushima I,Endo F,Yamashita Y

    更新日期:2005-03-01 00:00:00

  • Stability of ischemic core volume during the initial hours of acute large vessel ischemic stroke in a subgroup of mechanically revascularized patients.

    abstract:INTRODUCTION:This study aimed to relate growth of the infarct core with time to recanalization in patients receiving mechanical recanalization in whom the time of recanalization is known. METHODS:We analyzed data from patients with anterior circulation acute ischemic stroke who underwent mechanical recanalization. Dem...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-014-1329-z

    authors: Finitsis S,Kemmling A,Havemeister S,Thomalla G,Fiehler J,Brekenfeld C

    更新日期:2014-04-01 00:00:00

  • Incidence of side effects following direct puncture cervical myelography. Bed rest versus normal mobility.

    abstract::After cervical myelography by direct puncture at C 1/2 level, 120 patients were randomly allocated to one of two groups, in one the patients were allowed to be fully ambulant and in the other the regimen was bed rest for 24 h. Questionnaires recording the frequency and severity of side effects were completed at interv...

    journal_title:Neuroradiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00333297

    authors: Teasdale E,Macpherson P

    更新日期:1983-01-01 00:00:00

  • Dural arteriovenous malformations at the base of the anterior cranial fossa: report of nine cases.

    abstract::Nine men with dural arteriovenous malformations (DAVM) at the base of the anterior cranial fossa are described. Four patients had intracerebral haemorrhage and four had seizures, associated with haemorrhage in two. In three cases the fistula was an incidental finding. In five cases the diagnosis could be made before a...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00588378

    authors: Reul J,Thron A,Laborde G,Brückmann H

    更新日期:1993-01-01 00:00:00

  • Tuberculoma en plaque: CT.

    abstract::A 35-year-old woman presented with a 6-month history of intermittent headaches, vomiting and dizziness. CT showed a plaque-like mass with tiny calcifications along the surface of the left frontal lobe. The mass exhibited heterogeneous enhancement with a few low-density foci. Underlying sulcal obliteration and enhancem...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/BF00607273

    authors: Ng SH,Tang LM,Lui TN,Ko SF,Wong HF,Wai YY,Wan YL

    更新日期:1996-07-01 00:00:00

  • Axial 3D gradient-echo imaging for improved multiple sclerosis lesion detection in the cervical spinal cord at 3T.

    abstract:INTRODUCTION:In multiple sclerosis (MS), spinal cord imaging can help in diagnosis and follow-up evaluation. However, spinal cord magnetic resonance imaging (MRI) is technically challenging, and image quality, particularly in the axial plane, is typically poor compared to brain MRI. Because gradient-recalled echo (GRE)...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-012-1118-5

    authors: Ozturk A,Aygun N,Smith SA,Caffo B,Calabresi PA,Reich DS

    更新日期:2013-03-01 00:00:00

  • Nasal polyps with metaplastic ossification: CT and MR imaging findings.

    abstract:INTRODUCTION:Metaplastic ossification is a rare event in nasal polyps. The purpose of this study was to review the computed tomography (CT) and magnetic resonance (MR) imaging findings of nasal polyps with metaplastic ossification. METHODS:CT (n=5) and MR (n=3) images of five patients (four men and one woman; mean age...

    journal_title:Neuroradiology

    pub_type: 杂志文章

    doi:10.1007/s00234-010-0758-6

    authors: Kim YK,Kim HJ,Kim J,Chung SK,Kim E,Ko YH,Kim ST

    更新日期:2010-12-01 00:00:00