Incidental white-matter foci on MRI in "healthy" subjects: evidence of subtle cognitive dysfunction.

Abstract:

:The clinical significance of incidental white-matter foci seen on MRI is controversial. Mainly using a computer-assisted neuropsychological test battery, we tested the hypothesis that there is a clinical correlate of these foci. We studied 41 individuals aged 45-65 years with no history of neurological or psychiatric disorder, in whom no indication of central nervous system abnormalities was found on standardised neurological examination. A computer-assisted neuropsychological test battery, with the advantage of precise measuring of both time and deviation (e.g. in position memory tests), and rating scales for emotional dysfunction were administered; selected soft neurological signs were assessed. In 16 subjects (39%) MRI showed high-signal foci in the white matter on spin-echo sequences. White-matter foci not adjacent to the lateral ventricles were found to be related to performance on immediate visual memory/visuoperceptual skills, visuomotor tracking/psychomotor speed and, to a lesser degree, learning capacity and abstract and conceptual reasoning skills. Subtle cognitive dysfunction would appear to be a clinical correlate of punctate white-matter foci on MRI of otherwise "healty" individuals.

journal_name

Neuroradiology

journal_title

Neuroradiology

authors

Baum KA,Schulte C,Girke W,Reischies FM,Felix R

doi

10.1007/s002340050342

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

755-60

issue

8

eissn

0028-3940

issn

1432-1920

journal_volume

38

pub_type

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