A stimulatory role of cyclic adenosine 3',5'-monophosphate in follicle-stimulating hormone-activated mitogen-activated protein kinase signaling pathway in rat ovarian granulosa cells.

abstract：:Whereas the stimulatory effect of interleukin-6 (IL-6) on the hypothalamic-pituitary-adrenal (HPA) axis is well established, its mode of action in this axis has yet to be fully elucidated. To further study the role of IL-6 in the HPA axis, we compared the expression of IL-6 messenger RNA (mRNA) in the rat hypothalamus...

journal_title：Endocrinology

authors： Muramami N,Fukata J,Tsukada T,Kobayashi H,Ebisui O,Segawa H,Muro S,Imura H,Nakao K

更新日期：1993-12-01 00:00:00

abstract：:The neuroendocrine hormones ACTH and corticotropin- releasing factor (CRF), which are involved in the stress response, have acute effects on arterial pressure. New evidence indicates that urocortin (UCN), the putative agonist for the CRF type 2 receptor, has selective cardiovascular actions. The responses to long-term...

journal_title：Endocrinology

authors： Weisinger RS,Blair-West JR,Burns P,Denton DA,Purcell B,Vale W,Rivier J,Weisinger HS,May CN

更新日期：2004-12-01 00:00:00

abstract：:To determine whether glucagon plays a significant role in the restitution of blood volume after hemorrhage, pentobarbital-anesthetized dogs were treated with somatostatin (SRIF). The administration of SRIF (14 micrograms/kg.h) prevented the increase in osmolality and the complete restitution of plasma protein and bloo...

journal_title：Endocrinology

authors： Byrnes GJ,Engeland WC,Gann DS

更新日期：1982-06-01 00:00:00

abstract：:Thyroid hormone (T(3)) regulates growth, development, and differentiation. These activities are mediated by the nuclear thyroid hormone receptors (TRs), which belong to the steroid/TR superfamily of ligand-dependent transcription factors. The effect of T(3) treatment on target gene regulation was investigated in a TRa...

journal_title：Endocrinology

authors： Shih CH,Chen SL,Yen CC,Huang YH,Chen CD,Lee YS,Lin KH

更新日期：2004-06-01 00:00:00

abstract：:Breast cancer incidence increases in women receiving combined estrogen and progesterone therapy. Breast tumors show increased expression of the glucose transporter GLUT1. We determined the effect of these hormones on GLUT1-4 expression and deoxyglucose transport in ZR-75-1 breast cancer cells. Immunoblotting, immunocy...

journal_title：Endocrinology

authors： Medina RA,Meneses AM,Vera JC,Guzman C,Nualart F,Astuya A,García MA,Kato S,Carvajal A,Pinto M,Owen GI

更新日期：2003-10-01 00:00:00

abstract：:The role of GH during the ovine estrous cycle is unknown. In this study, pituitary GH mRNA and peripheral serum GH levels were measured in ewes representing the major phases of the estrous cycle. There was a significant rise (P less than 0.05) in both GH mRNA and serum GH concentrations during the follicular phase of ...

journal_title：Endocrinology

authors： Landefeld TD,Suttie JM

更新日期：1989-09-01 00:00:00

abstract：:The extensive colocalization of insulin receptor (IR) and insulin-like growth factor-I receptor (IGFR) messenger RNAs during central nervous system development, together with the effects of insulin and IGF-I in neurogenesis, raises the question of how stage- and factor-specific signaling occurs. Thus, it is necessary ...

journal_title：Endocrinology

authors： García-de Lacoba M,Alarcón C,de la Rosa EJ,de Pablo F

更新日期：1999-01-01 00:00:00

abstract：:Endothelin (ET) and GnRH act through specific receptors to promote Ca2+ mobilization and influx pathways in pituitary gonadotrophs. In the present study cytoplasmic calcium ([Ca2+]i) and secretory responses to these two agonists are compared. In single gonadotrophs, low concentrations of both agonists cause oscillator...

journal_title：Endocrinology

authors： Stojilković SS,Iida T,Cesnjaj M,Catt KJ

更新日期：1992-12-01 00:00:00

abstract：:The increase in glucagon-like peptide-1 (GLP-1) activity has emerged as a useful therapeutic tool for the treatment of type 2 diabetes mellitus. The actions of GLP-1 on β-cells and the nervous and digestive systems are well known. The action of this peptide in adipose tissue (AT), however, is still poorly defined. Fur...

journal_title：Endocrinology

authors： Vendrell J,El Bekay R,Peral B,García-Fuentes E,Megia A,Macias-Gonzalez M,Fernández Real J,Jimenez-Gomez Y,Escoté X,Pachón G,Simó R,Selva DM,Malagón MM,Tinahones FJ

更新日期：2011-11-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) is thought to confer aldosterone specificity to mineralocorticoid target cells by protecting the mineralocorticoid receptor from occupancy by endogenous glucocorticoids. We have recently described a novel isoform of 11-OHSD in the renal aldosterone target cells (11 b...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Fejes-Tóth G

更新日期：1995-06-01 00:00:00

abstract：:Biological actions of natriuretic peptide (NP) are determined by the condition of the receptor as well as that of the hormone. Although we previously demonstrated in hypertensive rats the up-regulation of NP-A receptor that mediates various biological actions of NPs, the pathophysiologic significance of NP-C receptor,...

journal_title：Endocrinology

authors： Yoshimoto T,Naruse M,Naruse K,Shionoya K,Tanaka M,Tanabe A,Hagiwara H,Hirose S,Muraki T,Demura H

更新日期：1996-03-01 00:00:00

abstract：:Phosphatidylinositol 3-kinase (PI3k) activity is required for the insulin stimulation of glucose transport in adipocytes and Chinese hamster ovary cells. Wortmannin (WM), an inhibitor of PI3k, inhibits the stimulation of glucose transport by insulin and the gain of glucose transporters at the cell surface. However, th...

journal_title：Endocrinology

authors： Tsakiridis T,McDowell HE,Walker T,Downes CP,Hundal HS,Vranic M,Klip A

更新日期：1995-10-01 00:00:00

abstract：:Anterior pituitary cells from adult male rats were cultured on a natural extracellular matrix (ECM). From the 5th day, spindle-shaped cells, fusing to form elongated fibers, were observed among the epithelial cells. These fibers later increased in size and number and were identified as striated muscle fibers, based on...

journal_title：Endocrinology

authors： Spira O,Atzmon R,Rahamim E,Bar-Shavit R,Gross J,Gordon A,Vlodavsky I

更新日期：1988-06-01 00:00:00

abstract：:The levels of the GnRH receptor (GnRHR) and its messenger RNA depend on the pattern of administration of GnRH. In this study, internal deletion mutants in a luciferase reporter gene vector (GnRHR-pXP2) containing a 1226-bp promoter fragment of mouse GnRHR gene were used to examine the regulation of GnRHR gene transcri...

journal_title：Endocrinology

authors： Maya-Núñez G,Conn PM

更新日期：1999-08-01 00:00:00

abstract：:Epigenetic aberrations, including DNA methylation, histone modifications, and micro-RNA dysregulation, are now well established in the development and progression of ovarian cancer, and their gradual accumulation is associated with advancing disease stage and grade. Epigenetic aberrations are relatively stable, associ...

journal_title：Endocrinology

authors： Balch C,Fang F,Matei DE,Huang TH,Nephew KP

更新日期：2009-09-01 00:00:00

abstract：:This study analyzes the role of the autonomic nervous system, the pituitary gland, ACTH, dexamethasone (DEX), and thyroid hormones in the regulation of 5'deiodinase (5'D) in the hypothalamus (HP) and adrenal gland (AG) of the rat. 5'D activity was analyzed in rats under basal conditions (22 C) and during cold exposure...

journal_title：Endocrinology

authors： Anguiano B,Quintanar A,Luna M,Navarro L,Ramírez del Angel A,Pacheco P,Valverde C

更新日期：1995-08-01 00:00:00

abstract：:Although prolactinomas can be effectively treated with dopamine agonists, about 20% of patients develop dopamine resistance or tumor recurrence after surgery, indicating a need for better understanding of underlying disease mechanisms. Although estrogen-induced rat prolactinomas have been widely used to investigate th...

journal_title：Endocrinology

authors： Tong Y,Zheng Y,Zhou J,Oyesiku NM,Koeffler HP,Melmed S

更新日期：2012-08-01 00:00:00

abstract：:The proglucagon gene (glu) encodes the incretin hormone glucagon-like peptide-1 (GLP-1), produced in the intestinal endocrine L cells. We found previously that the bipartite transcription factor beta-catenin/T cell factor (cat/TCF), the major effector of the canonical Wnt signaling pathway, activates intestinal glu ex...

journal_title：Endocrinology

authors： Yi F,Sun J,Lim GE,Fantus IG,Brubaker PL,Jin T

更新日期：2008-05-01 00:00:00

abstract：:Insulin resistance and type 2 diabetes mellitus are associated with impaired postprandial secretion of glucagon-like peptide-1 (GLP-1), a potent insulinotropic hormone. The direct effects of insulin and insulin resistance on the L cell are unknown. We therefore hypothesized that the L cell is responsive to insulin and...

journal_title：Endocrinology

authors： Lim GE,Huang GJ,Flora N,LeRoith D,Rhodes CJ,Brubaker PL

更新日期：2009-02-01 00:00:00

abstract：:Circadian clocks have been described in each tissue of the hypothalamo-pituitary-ovarian axis. Although a role for the clock in the timing of ovulation is indicated, the impact of diseases that disrupt fertility on clock function or the clocks' role in the etiology of these pathologies has yet to be fully appreciated....

journal_title：Endocrinology

authors： Sellix MT,Murphy ZC,Menaker M

更新日期：2013-04-01 00:00:00

abstract：:The divergent commitment of ovarian granulosa cells to either proliferation and differentiation or programmed cell death directly reflects the process of follicular dominance and atresia. This process is regulated by FSH and local paracrine factors. To further analyze the role of FSH and intraovarian factors in follic...

journal_title：Endocrinology

authors： Li R,Phillips DM,Moore A,Mather JP

更新日期：1997-07-01 00:00:00

abstract：:Sterol regulatory element binding protein 1c (SREBP1c) is a master regulator of lipogenic gene expression in liver and adipose tissue, where its expression is regulated by a heterodimer of nuclear receptor-type transcription factors retinoid X receptor-alpha (RXRalpha) and liver X receptor-alpha (LXRalpha). Despite th...

journal_title：Endocrinology

authors： Kamei Y,Miura S,Suganami T,Akaike F,Kanai S,Sugita S,Katsumata A,Aburatani H,Unterman TG,Ezaki O,Ogawa Y

更新日期：2008-05-01 00:00:00

abstract：:The type 2 iodothyronine deiodinase (D2) is essential for feedback regulation of TSH by T4. We genetically inactivated in vivo D2 in thyrotrophs using a mouse model of Cga-driven cre recombinase. Pituitary D2 activity was reduced 90% in the Cga-cre D2 knockout (KO) mice compared with control Dio2(fl/fl) mice. There wa...

journal_title：Endocrinology

authors： Luongo C,Martin C,Vella K,Marsili A,Ambrosio R,Dentice M,Harney JW,Salvatore D,Zavacki AM,Larsen PR

更新日期：2015-02-01 00:00:00

abstract：:Ghrelin is a peptide hormone primarily produced in the previously unidentified X/A endocrine cells of the stomach. Extensive studies have focused on the effects of ghrelin on growth hormone release and appetite regulation. However, the mechanisms regulating ghrelin secretion are less understood. In the present study, ...

journal_title：Endocrinology

authors： Gagnon J,Anini Y

更新日期：2012-08-01 00:00:00

abstract：:Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disease caused by mutations in the vitamin D receptor (VDR). We studied a young Saudi Arabian girl who exhibited the typical clinical features of HVDRR, but without alopecia. Analysis of her VDR gene revealed a homozygous T to C mutation in exon ...

journal_title：Endocrinology

authors： Malloy PJ,Xu R,Peng L,Peleg S,Al-Ashwal A,Feldman D

更新日期：2004-11-01 00:00:00

abstract：:We tested further our postulate that enhanced de novo synthesis of phosphatidic acid is responsible for ACTH- and cAMP-induced increases in adrenal phospholipids in the phosphatidate polyphosphoinositide pathway. During incubation of adrenal sections or cells in vitro, ACTH and cAMP increased the concentrations of and...

journal_title：Endocrinology

authors： Farese RV,Sabir MA,Larson RE

更新日期：1981-12-01 00:00:00

abstract：:The regression of the tadpole tail is under the direct control of the thyroid hormones and offers a unique system for the study of the action of these hormones. We have examined the binding of L-triiodothyronine (T3) and L-thyroxine (T4) in vitro using tail fin bricks which included epidermal and connective cells. The...

journal_title：Endocrinology

authors： Yoshizato K,Kistler A,Frieden E

更新日期：1975-10-01 00:00:00

abstract：:Equine CG (eCG) both radioiodinated and unlabeled, was injected iv into male rats, and the disappearance of the hormone from the circulation was studied. The uptake and inactivation of the hormone by various tissues was also examined. The disappearance curve of eCG consisted of two exponential components with apparent...

journal_title：Endocrinology

authors： Aggarwal BB,Papkoff H

更新日期：1981-10-01 00:00:00

abstract：:RNA blot hybridization analysis with cloned rat CRF precursor (prepro-CRF) cDNA as a probe showed that prepro-CRF mRNA existed in rat hypothalamic and extrahypothalamic brain tissue, whereas it was undetectable in the pituitary and adrenal. To study the effect of glucocorticoid on the level of prepro-CRF mRNA in the h...

journal_title：Endocrinology

authors： Jingami H,Matsukura S,Numa S,Imura H

更新日期：1985-10-01 00:00:00

abstract：:Previous studies had suggested that norepinephrine (NE) and its precursors dopamine (DA) and L-DOPA acted similarly on iodine metabolism of isolated thyroid cells. Present studies indicate that this similarity extends to the inhibition by catecholamines of TSH-stimulated T4 release by mouse thyroids incubated in vitro...

journal_title：Endocrinology

authors： Maayan ML,Sellitto RV,Volpert EM

更新日期：1986-02-01 00:00:00