Type I von Willebrand disease, subtype 'platelet low': decreased platelet adhesion can be explained by low synthesis of von Willebrand factor in endothelial cells.

abstract：:We report a Lancashire family with mild haemophilia B associated with a -6 G to A mutation in the factor IX promoter. This mutation has been reported previously in Britain in one other affected family. The factor IX haplotype of these two unrelated patients was determined by PCR analysis of seven polymorphic sites wit...

journal_title：British journal of haematology

authors： Stowell KM,Figueiredo MS,Brownlee GG,Jones P,Bolton-Maggs PH

更新日期：1993-09-01 00:00:00

abstract：:Little is known about the impact of cytomegalovirus (CMV) infections that occur after human leucocyte antigen (HLA)-matched unrelated donor (MUD) non-myleoablative haematopoietic stem cell transplantation (HCT). We analysed the incidence, onset and outcomes of CMV infections in 59 recipients of MUD and in 109 recipien...

journal_title：British journal of haematology

authors： Junghanss C,Storb R,Maris MB,Carter RA,Sandmaier BM,Maloney DG,McSweeney PA,Corey L,Boeckh M

更新日期：2003-11-01 00:00:00

abstract：:Red cell lifespan has been measured using 51Cr and 59Fe in 19 patients. 59Fe can be used to give results which agree closely with those obtained using 51Cr provided that the plasma 59Fe clearance curve is properly defined and the data analysed correctly. In some patients elution of 51Cr may be more than three times th...

journal_title：British journal of haematology

authors： Ricketts C,Cavill I,Napier JA

更新日期：1977-11-01 00:00:00

abstract：:Amiodarone has been implicated as a cause of thrombocytopenia but the responsible mechanism is unknown. We performed studies in three patients to characterize the pathogenesis of this complication. No amiodarone-dependent, platelet-reactive antibodies were identified using conventional serological techniques. However,...

journal_title：British journal of haematology

authors： Sahud MA,Caulfield M,Clarke N,Koch R,Bougie D,Aster R

更新日期：2013-10-01 00:00:00

abstract：:It is widely recognized that thrombosis is the major event in the evolution of stable vascular disease to unstable ischaemic syndromes including myocardial infarction and stroke. The purpose of this case-control study was to establish clinical and laboratory data on the possible relationship between specific component...

journal_title：British journal of haematology

authors： Freeburn JC,Wallace JM,Strain JJ,Sinnamon DG,Craig BM,Johnson D,Gilmore WS

更新日期：1998-07-01 00:00:00

abstract：:The erythrocyte chemokine receptor, a receptor for Plasmodium vivax, carries the antigens of the Duffy blood group system. Sequence analysis of reticulocyte RNA from individuals of known Duffy phenotype showed that the Fya antigen differs from the Fyb antigen as a result of a single nucleotide difference (A131 or G) e...

journal_title：British journal of haematology

authors： Mallinson G,Soo KS,Schall TJ,Pisacka M,Anstee DJ

更新日期：1995-08-01 00:00:00

abstract：:The incidence, characteristics and risk factors for the development of osteonecrosis of the jaw (ONJ) were evaluated among 303 myeloma patients. Only patients who received bisphosphonates developed ONJ (28/254; 11%). Zoledronic acid produced 9.5-fold greater risk for developing ONJ than pamidronate alone (P = 0.042) a...

journal_title：British journal of haematology

authors： Zervas K,Verrou E,Teleioudis Z,Vahtsevanos K,Banti A,Mihou D,Krikelis D,Terpos E

更新日期：2006-09-01 00:00:00

abstract：:This study assessed the incidence of immune thrombocytopenia (ITP) and characteristics associated with ITP in the paediatric population using the General Practice Research Database (GPRD). Two hundred and fifty-seven paediatric ITP patients were identified out of 1145 incident patients with ITP recorded between 1990 a...

journal_title：British journal of haematology

authors： Yong M,Schoonen WM,Li L,Kanas G,Coalson J,Mowat F,Fryzek J,Kaye JA

更新日期：2010-06-01 00:00:00

abstract：:Human amniotic fluid has been shown to contain blood group i as well as I antigens. Crude extracts of amniotic fluids at 16-23 weeks of gestation were in general more active than those obtained at term. A pool of amniotic fluids which had A, B, H as well as I and i activity was fractionated with an insolubilized anti-...

journal_title：British journal of haematology

authors： Feizi T,Cederqvist LL,Childs R

更新日期：1975-08-01 00:00:00

abstract：:Assessment of chronic hepatitis C virus infection requires a liver biopsy in most circumstances. There is a reluctance to perform liver biopsy in haemophiliacs because of a perceived risk of haemorrhage, although with adequate factor concentrate replacement in patients without factor concentrate inhibitors it should b...

journal_title：British journal of haematology

authors： Wong VS,Baglin T,Beacham E,Wight DD,Petrik J,Alexander GJ

更新日期：1997-05-01 00:00:00

abstract：:A serial study of coagulation activation and whole-blood viscosity was performed on 37 patients with local or systemic bacterial infection, malaria, or a viral infection. Thrombocytopenia, without consumption of coagulation factors, was the main feature of benign tertian malaria and viral infection, whereas in septica...

journal_title：British journal of haematology

authors： Richardson SG,Matthews KB,Cruickshank JK,Geddes AM,Stuart J

更新日期：1979-07-01 00:00:00

abstract：:When monocytic leukaemia line U937 cells were incubated in the presence of HgCl2 there was a rapid increase in tissue factor (TF)-dependent procoagulant activity, reaching a maximum (equivalent to the total TF activity observed when cells had been subjected to a freeze/thaw cycle) after 15 min at 50 microM HgCl2 and a...

journal_title：British journal of haematology

authors： Kaneko H,Kakkar VV,Scully MF

更新日期：1994-05-01 00:00:00

abstract：:Juvenile myelomonocytic leukaemia (JMML) is a unique myeloproliferative disorder of early childhood. Frequently, mutations in NRAS, KRAS, PTPN11, NF1 or CBL are found in these patients. Monosomy 7 is the most common cytogenetic aberration. To identify submicroscopic genomic copy number alterations, 20 JMML samples wer...

journal_title：British journal of haematology

authors： Ripperger T,Tauscher M,Praulich I,Pabst B,Teigler-Schlegel A,Yeoh A,Göhring G,Schlegelberger B,Flotho C,Niemeyer CM,Steinemann D

更新日期：2011-10-01 00:00:00

abstract：:Limited therapies exist for patients with refractory and relapsed (RR) higher-risk myelodysplastic syndromes (HR-MDS) and acute myeloid leukaemia with trilineage dysplasia (AML-TD). High dose (HD) lenalidomide (50 mg) has activity as frontline therapy in elderly AML but there is limited data in the RR setting. This ph...

journal_title：British journal of haematology

authors： Zeidan AM,Smith BD,Carraway HE,Gojo I,DeZern A,Gore SD

更新日期：2017-01-01 00:00:00

abstract：:Thirty-two patients with meningeal leukaemia who achieved meningeal remission with intrathecal methotrexate (MTX) plus dexamethasone (DMT) were entered in a randomized study of two maintenance treatments: (a) I6 patients received intermittent intrathecal doses of MTX plus DMT, and (b) I6 patients received intermittent...

journal_title：British journal of haematology

authors： Muriel FS,Schere D,Barengols A,Eppinger-Helft M,Braier JL,Pavlovsky S,Macchi GH,Guman L

更新日期：1976-09-01 00:00:00

abstract：:Seven children (age range 1.8-11 years) with juvenile chronic myelomonocytic leukaemia (JCML) received an allogeneic bone marrow transplantation (BMT), four from an HLA-identical sibling and three from a matched unrelated donor. In the four children transplanted using an HLA-identical sibling, conditioning regimen inc...

journal_title：British journal of haematology

authors： Locatelli F,Pession A,Comoli P,Bonetti F,Giorgiani G,Zecca M,Taibi RM,Mongini ME,Ambroselli F,de Stefano P,Severi F,Paolucci G

更新日期：1996-01-01 00:00:00

abstract：:The H-2Kappab temperature-sensitive (ts) A58 transgenic (Immorto) mouse has been used previously to generate conditionally immortalized cells from a number of tissues. The present study aimed to investigate characteristics of primitive myeloid precursor cells derived from H-2Kappab-tsA58 bone marrow. Cell populations ...

journal_title：British journal of haematology

authors： Lee C,Evans CA,Spooncer E,Pierce A,Mottram R,Whetton AD

更新日期：2003-09-01 00:00:00

abstract：:Virchow's triad describes three factors that contribute to the development of venous thrombosis: hypercoagulability, stasis and endothelial injury. Yet, extensive review of the historical literature casts doubt on the existence of a triad described by Virchow in the form it is currently quoted throughout contemporary ...

journal_title：British journal of haematology

authors： Bagot CN,Arya R

更新日期：2008-10-01 00:00:00

abstract：:Myelodysplastic syndrome (MDS) is a common neoplasm of haematopoietic pluripotent stem cells. Although one third of MDS patients evolve to acute myeloid leukaemia (AML), little is understood about the mechanisms responsible for this progression. We have previously detected the frequent loss of heterozygosity (LOH) on ...

journal_title：British journal of haematology

authors： Mori N,Morosetti R,Mizoguchi H,Koeffler HP

更新日期：2003-07-01 00:00:00

abstract：:Givinostat, a histone-deacetylase inhibitor (HDACi), inhibits proliferation of cells bearing the JAK2 V617F mutation and has shown significant activity with good tolerability in patients with chronic myeloproliferative neoplasms (MPN). In this multicentre, open-label, phase II study, 44 patients with polycythaemia ver...

journal_title：British journal of haematology

authors： Finazzi G,Vannucchi AM,Martinelli V,Ruggeri M,Nobile F,Specchia G,Pogliani EM,Olimpieri OM,Fioritoni G,Musolino C,Cilloni D,Sivera P,Barosi G,Finazzi MC,Di Tollo S,Demuth T,Barbui T,Rambaldi A

更新日期：2013-06-01 00:00:00

abstract：:Anaplastic large cell lymphomas (ALCLs) are rare CD30+ peripheral T-cell lymphomas (PTCLs) classified according to the expression of the anaplastic lymphoma kinase (ALK+) protein or not (ALK-). We have analysed the outcome and risk factors for survival in a population-based bi-national cohort of patients with systemic...

journal_title：British journal of haematology

authors： Cederleuf H,Bjerregård Pedersen M,Jerkeman M,Relander T,d'Amore F,Ellin F

更新日期：2017-09-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH), the most common histiocytic disorder, is characterized by the accumulation of CD1A(+) /CD207(+) mononuclear phagocytes within granulomatous lesions that can affect nearly all organ systems. Historically, LCH has been presumed to arise from transformed or pathologically activated ep...

journal_title：British journal of haematology

authors： Berres ML,Merad M,Allen CE

更新日期：2015-04-01 00:00:00

abstract：:We have tested the different mononuclear blood cell populations of seven patients with severe haemophilia and one patient with F VII deficiency for the presence of HBV DNA. These subjects were all polytransfused with non-heated coagulation factors; three were HBsAg positive, five HBsAg negative but anti-HBc and anti-H...

journal_title：British journal of haematology

authors： Lauré F,Chatenoud L,Pasquinelli C,Gazengel C,Beaurain G,Torchet MF,Zagury D,Bach JF,Bréchot C

更新日期：1987-02-01 00:00:00

abstract：:To explore the possible role of a residual or variant alphaIIbbeta3 integrin (alphaIIbbeta3) in thrombogenesis, we used a new ex vivo perfusion chamber model to examine blood from patients with different subtypes of Glanzmann's thrombasthenia (GT). Non-anticoagulated blood was perfused through capillaries coated with ...

journal_title：British journal of haematology

authors： Hainaud P,Brouland JP,André P,Simoneau G,Bal Dit Sollier C,Drouet L,Caen J,Bellucci S

更新日期：2002-12-01 00:00:00

abstract：:Thirty-four patients with refractory multiple myeloma were treated with 4-d continuous infusions of vincristine and adriamycin in combination with 4-d pulsed high-dose dexamethasone (VAD). Of 31 evaluable patients, 16 entered a complete remission (50%) and three a partial remission (10%). No difference in response rat...

journal_title：British journal of haematology

authors： Lokhorst HM,Meuwissen OJ,Bast EJ,Dekker AW

更新日期：1989-01-01 00:00:00

abstract：:Genetic variation in innate immunity may alter host-pathogen defence mechanisms and promote aberrant immune responses and non-Hodgkin lymphoma (NHL). To test this hypothesis, we investigated polymorphisms in innate immune genes in a pooled analysis of two population-based case-control studies of NHL from the San Franc...

journal_title：British journal of haematology

authors： Forrest MS,Skibola CF,Lightfoot TJ,Bracci PM,Willett EV,Smith MT,Holly EA,Roman E

更新日期：2006-07-01 00:00:00

abstract：:A total of 229 patients with chronic myeloid leukaemia (CML) in chronic phase were randomized between 1986 and 1990 to receive or not receive additional splenic irradiation as part of their conditioning prior to bone marrow transplantation (BMT). Both groups, 115 patients with and 114 patients without splenic irradiat...

journal_title：British journal of haematology

authors： Gratwohl A,Hermans J,van Biezen A,Arcese W,Debusscher L,Ernst P,Ferrant A,Frassoni F,Gahrton G,Iriondo A,Kolb HJ,Link H,Niederwieser D,Ruutu T,Siegert W,Zwaan FE

更新日期：1996-12-01 00:00:00

abstract：:Previous studies report conflicting results concerning the potential significance of thrombophilic genotypes in postarthroplasty venous thromboembolism (VTE). This study assessed thrombophilic genotypes, haemostatic and clinical variables as independent risk factors for VTE postarthroplasty. A total number of 569 pati...

journal_title：British journal of haematology

authors： Joseph JE,Low J,Courtenay B,Neil MJ,McGrath M,Ma D

更新日期：2005-04-01 00:00:00

abstract：:Novel therapies have transformed the treatment paradigm for multiple myeloma with significant improvements in survival now seen in both younger and older patients. Nonetheless, the disease is heterogeneous and high-risk patients in particular continue to have poor outcome. Moreover, the disease remains incurable. Effo...

journal_title：British journal of haematology

authors： Richardson PG,Laubach J,Mitsiades CS,Schlossman R,Hideshima T,Redman K,Chauhan D,Ghobrial IM,Munshi N,Anderson KC

更新日期：2011-09-01 00:00:00

abstract：:Follicular lymphoma (FL) is a heterogeneous disease; therefore, reliable prognostic tools are needed to plan treatment strategies. The FL International Prognostic Index (FLIPI) was developed before the rituximab era, while the PRIMA-PI was built on rituximab chemotherapy. Our objective was to evaluate these two progno...

journal_title：British journal of haematology

authors： Kimby E,Lockmer S,Holte H,Hagberg H,Wahlin BE,Brown P,Østenstad B

更新日期：2020-05-14 00:00:00