Abstract:
:Exosomes are 60 to 90 nm membrane vesicles originating from late endosomes and secreted from most hematopoietic and epithelial cells in vitro. B cell derived-exosome antigenicity was first reported in 1996 in MHC class II restricted CD4+ T lymphocytes. In 1998, we reported that dendritic cell derived-exosomes are immunogenic in mice leading to tumor rejection. These findings have renewed the interest in exosomes. The current challenge consists in understanding the mechanisms and the physiological relevance of exosomes that could contribute to the design of the optimal exosome based-vaccination. Here, we will focus on the biological features pertaining to dendritic cell- and tumor cell derived-exosomes and will discuss their potential clinical implementation.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Chaput N,Schartz NE,Andre F,Zitvogel Ldoi
10.1007/978-1-4615-0081-0_17subject
Has Abstractpub_date
2003-01-01 00:00:00pages
215-21eissn
0065-2598issn
2214-8019journal_volume
532pub_type
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journal_title:Advances in experimental medicine and biology
pub_type: 临床试验,杂志文章
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journal_title:Advances in experimental medicine and biology
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