Radiological progression in rheumatoid arthritis: how many patients are required in a treatment trial to test disease modification?

abstract：OBJECTIVE:To study the value of antibodies to citrullinated proteins/peptides for predicting joint outcomes in patients with recent onset rheumatoid arthritis (RA). METHODS:191 patients with RA onset within the past year were followed up prospectively for five years. Serum samples obtained from 145 patients at baselin...

journal_title：Annals of the rheumatic diseases

authors： Meyer O,Labarre C,Dougados M,Goupille P,Cantagrel A,Dubois A,Nicaise-Roland P,Sibilia J,Combe B

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVES:To assess the long-term effect of bariatric surgery on the incidence of gout and hyperuricaemia in participants of the Swedish Obese Subjects (SOS) study. METHODS:This report includes 1982 subjects who underwent bariatric surgery and 1999 obese controls from the SOS study, a prospective intervention trial d...

journal_title：Annals of the rheumatic diseases

authors： Maglio C,Peltonen M,Neovius M,Jacobson P,Jacobsson L,Rudin A,Carlsson LM

更新日期：2017-04-01 00:00:00

abstract：:Fourteen patients with cystic fibrosis arthritis and eight patients with cystic fibrosis and hypertrophic osteoarthropathy were typed for HLA-A, B, C, DR, and DQ antigens and were compared with age and sex matched controls with cystic fibrosis. The diagnosis of cystic fibrosis arthritis and hypertrophic osteoarthropat...

journal_title：Annals of the rheumatic diseases

authors： Rush PJ,Gladman DD,Shore A,Anhorn KA

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:The MEFV gene is responsible for familial Mediterranean fever (FMF). Several disease associated mutations have been identified. The range of genetic variation in MEFV in Greek patients has not been determined. OBJECTIVE:To describe a method that facilitates the routine screening of the entire coding sequenc...

journal_title：Annals of the rheumatic diseases

authors： Ritis K,Giaglis S,Spathari N,Micheli A,Zonios D,Tzoanopoulos D,Deltas CC,Rafail S,Mean R,Papadopoulos V,Tzioufas AG,Moutsopoulos HM,Kartalis G

更新日期：2004-04-01 00:00:00

abstract：:In a comparative study of antinuclear antibodies (ANA) and immune complexes in the serum of 43 patients with systemic sclerosis (SS) ANA were detected by indirect immunofluorescence on Hep 2 cells and/or double immunodiffusion in 90% of patients, while immune complex assays were positive in 32% of patients. The immune...

journal_title：Annals of the rheumatic diseases

authors： French MA,Harrison G,Penning CA,Cunningham J,Hughes P,Rowell NR

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:To determine discrepancies in patients' current use and expected future use of the internet for different functions. METHOD:A short questionnaire was developed to assess patients' current use of the internet for three functions: "seeking information", "mutual support", and "care provider contact". This quest...

journal_title：Annals of the rheumatic diseases

authors： van Lankveld WG,Derks AM,van den Hoogen FH

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Interferon (IFN) beta displays anti-inflammatory and immunosuppressive activity and has been considered for the treatment of rheumatoid arthritis (RA). Information about the effects of this molecule on joint cells is scarce, however. OBJECTIVE:To investigate the effects of IFNbeta on the production of inter...

journal_title：Annals of the rheumatic diseases

authors： Palmer G,Mezin F,Juge-Aubry CE,Plater-Zyberk C,Gabay C,Guerne PA

更新日期：2004-01-01 00:00:00

abstract：:A patient with systemic lupus erythematosus was first diagnosed after she had developed the Budd-Chiari syndrome. We believe that the Budd-Chiari syndrome was part of her tendency for thrombosis, induced by the presence of a lupus anticoagulant. The association between enhanced thrombosis and the lupus anticoagulant i...

journal_title：Annals of the rheumatic diseases

authors： Averbuch M,Levo Y

更新日期：1986-05-01 00:00:00

abstract：OBJECTIVE:To examine the effect of infliximab plus methotrexate (MTX) compared with placebo plus MTX on bone loss in patients with early rheumatoid arthritis (RA) in a double-blind randomised study design. Further, to explore the associations between bone loss and markers of RA disease. METHODS:All 20 patients with RA...

journal_title：Annals of the rheumatic diseases

authors： Haugeberg G,Conaghan PG,Quinn M,Emery P

更新日期：2009-12-01 00:00:00

abstract：:Three aspects of polymorphonuclear leucocyte (PMN) function were studied in 19 patients with Behçet's syndrome (BS). By 2 different techniques directed motility was found to be increased. This increase was largely due to the subgroup of patients with ocular involvement. Counts of absolute numbers of cells migrating hi...

journal_title：Annals of the rheumatic diseases

authors： Fordham JN,Davies PG,Kirk A,Currey HL

更新日期：1982-08-01 00:00:00

abstract：OBJECTIVES:Hyperplasia of synovial fibroblasts, infiltration with lymphocytes and tissue hypoxia are major characteristics of rheumatoid arthritis (RA). Extensive data support a key role for toll-like receptors (TLRs) in RA. Little is known regarding the impact of hypoxia on TLR-induced inflammation in RA. The aim of t...

journal_title：Annals of the rheumatic diseases

authors： Hu F,Mu R,Zhu J,Shi L,Li Y,Liu X,Shao W,Li G,Li M,Su Y,Cohen PL,Qiu X,Li Z

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:The Health Assessment Questionnaire Disability Index (HAQ-DI) is the most widely used measure of function in rheumatoid arthritis (RA). OBJECTIVE:To evaluate individualised forms of the HAQ-DI and thus enhance the incorporation of patients' views in outcome assessment. PATIENTS AND METHODS:HAQ-DI data were...

journal_title：Annals of the rheumatic diseases

authors： Seror R,Tubach F,Baron G,Guillemin F,Ravaud P

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The pathogenesis of the early stages of hand osteoarthritis is poorly understood, but recent high-resolution magnetic resonance imaging (hrMRI) studies suggest that the joint ligaments have a major role in the phenotypic expression of the disease. OBJECTIVE:To combine hrMRI and cadaveric histological studie...

journal_title：Annals of the rheumatic diseases

authors： Tan AL,Toumi H,Benjamin M,Grainger AJ,Tanner SF,Emery P,McGonagle D

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVES:To evaluate changes in bone mineral density (BMD) in the hands, hip and spine after 1 and 2 years of follow-up, in relation to antirheumatic and antiresorptive therapies and disease and demographic variables in patients with recent-onset rheumatoid arthritis (RA). METHODS:Changes in BMD measured in metacarp...

journal_title：Annals of the rheumatic diseases

authors： Güler-Yüksel M,Allaart CF,Goekoop-Ruiterman YP,de Vries-Bouwstra JK,van Groenendael JH,Mallée C,de Bois MH,Breedveld FC,Dijkmans BA,Lems WF

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:To compare arterial haemodynamics in adults with long-term juvenile idiopathic arthritis (JIA) to that of healthy controls, and explore the influence of traditional cardiovascular risk factors and disease characteristics on arterial haemodynamics plus coronary artery calcification. METHODS:87 JIA patients (m...

journal_title：Annals of the rheumatic diseases

authors： Aulie HA,Selvaag AM,Günther A,Lilleby V,Molberg Ø,Hartmann A,Holdaas H,Flatø B

更新日期：2015-08-01 00:00:00

abstract：:A six month controlled study of 5-fluorouracil in the treatment of scleroderma showed a modest benefit in skin scores, Raynaud's phenomenon, and patients' global assessment. Visceral organ and hand function were unaffected. Mild to moderate toxicity was common in the 5-fluorouracil treated patients but usually respond...

journal_title：Annals of the rheumatic diseases

authors： Casas JA,Saway PA,Villarreal I,Nolte C,Menajovsky BL,Escudero EE,Blackburn WD,Alarcón GS,Subauste CP

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVE:To investigate polymorphisms of both codon 54 allele and promoter variants of the mannose binding lectin (MBL) gene in patients with primary Sjögren's syndrome (SS). METHODS:Polymorphisms of codon 54 allele and promoter variants of the MBL gene in 104 patients with SS and 143 healthy controls were determined...

journal_title：Annals of the rheumatic diseases

authors： Wang ZY,Morinobu A,Kanagawa S,Kumagai S

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVES:To determine whether rheumatoid factors (RFs), measured as continuous variables by time resolved fluoroimmunoassay, reflect disease activity in rheumatoid arthritis (RA). Further, to study the association of RFs and other disease activity parameters with radiological joint damage, especially in individual pa...

journal_title：Annals of the rheumatic diseases

authors： Knijff-Dutmer E,Drossaers-Bakker W,Verhoeven A,van der Sluijs Veer G,Boers M,van der Linden S,van de Laar M

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:Despite the lower prevalence of obesity (a known risk factor for osteoarthritis (OA)), the prevalence of lateral tibiofemoral OA is higher in Chinese communities compared with Caucasian communities. One potential explanation is the difference in knee alignment between the two populations. We measured various ...

journal_title：Annals of the rheumatic diseases

authors： Harvey WF,Niu J,Zhang Y,McCree PI,Felson DT,Nevitt M,Xu L,Aliabadi P,Hunter DJ

更新日期：2008-11-01 00:00:00

abstract：:In a double blind, single observer, 48 week study the effects of sulphasalazine (2 g daily) and hydroxychloroquine (400 mg daily months 0-6, thereafter 200 mg daily) were compared in 60 patients with definite or classical rheumatoid arthritis. They had not been treated previously with second line drugs. The onset of r...

journal_title：Annals of the rheumatic diseases

authors： Nuver-Zwart IH,van Riel PL,van de Putte LB,Gribnau FW

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVES:To perform a systematic literature review of effective strategies for the treatment of rheumatoid arthritis (RA). METHODS:As part of a European League Against Rheumatism (EULAR) Task Force investigation, a literature search was carried out from January 1962 until February 2009 in PubMed/Ovid Embase/Cochrane...

journal_title：Annals of the rheumatic diseases

authors： Knevel R,Schoels M,Huizinga TW,Aletaha D,Burmester GR,Combe B,Landewé RB,Smolen JS,Sokka T,van der Heijde DM

更新日期：2010-06-01 00:00:00

abstract：:A 60-year-old man with destructive rheumatoid disease, multiple nodules, and vasculitis developed a facial rash with ulceration and scarring. Histology showed granulomatous vasculitis. The rash was rapidly controlled with oral corticosteroids. Granulomatous vasculitis has not previously been reported as causing this c...

journal_title：Annals of the rheumatic diseases

authors： White R,Wegman A,Bulpitt P,Wood G,Fleming A

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Entheseal fibrocartilage (EF) derangement is hypothesised to be pivotal to the pathogenesis of spondyloarthritis. Ultrasound is useful for visualisation of the enthesis but its role in EF visualisation is uncertain. This work aimed to demonstrate face and content validity of ultrasound for EF visualisation b...

journal_title：Annals of the rheumatic diseases

authors： Aydin SZ,Bas E,Basci O,Filippucci E,Wakefield RJ,Celikel C,Karahan M,Atagunduz P,Benjamin M,Direskeneli H,McGonagle D

更新日期：2010-12-01 00:00:00

abstract：:The case presented is of a patient with migratory polyarthritis and serological evidence of a recent streptococcal infection, consistent with the diagnosis of acute rheumatic fever, who in addition had multisystem disease manifestations. This case supports the concept that the sequelae of streptococcal infection can e...

journal_title：Annals of the rheumatic diseases

authors： Livneh A,Sharma K,Sewell KL,Keiser HD

更新日期：1991-05-01 00:00:00

abstract：OBJECTIVES:Wnt16 is implicated in bone fracture and bone mass accrual both in animals and humans. However, its functional roles and molecular mechanism in chondrocyte differentiation and osteoarthritis (OA) pathophysiology remain largely undefined. In this study, we analysed its mechanistic association and functional r...

journal_title：Annals of the rheumatic diseases

authors： Tong W,Zeng Y,Chow DHK,Yeung W,Xu J,Deng Y,Chen S,Zhao H,Zhang X,Ho KK,Qin L,Mak KK

更新日期：2019-04-01 00:00:00

abstract：:A study of the walking activities of 243 individuals was carried out. The individuals came from four different occupations and had an age range of 17-83 years. The survey carried out in this investigation showed surprisingly little correlation between variables such as age, height, and weight of individuals and their ...

journal_title：Annals of the rheumatic diseases

authors： Seedhom BB,Wallbridge NC

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVES:To investigate whether anti-Saccharomyces cerevisiae antibodies (ASCA), a marker for Crohn's disease (CD), are present in spondyloarthropathies (SpA) and in the subgroups ankylosing spondylitis (AS), undifferentiated SpA (uSpA), and psoriatic arthritis (PsA), in comparison with healthy and inflammatory contr...

journal_title：Annals of the rheumatic diseases

authors： Hoffman IE,Demetter P,Peeters M,De Vos M,Mielants H,Veys EM,De Keyser F

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Previous data have shown that etanercept levels are associated with clinical response in rheumatoid arthritis. However, for ankylosing spondylitis (AS), data regarding this topic are inconclusive. OBJECTIVES:To investigate the relationship between etanercept levels and clinical response in patients with AS....

journal_title：Annals of the rheumatic diseases

authors： Kneepkens EL,Krieckaert CL,van der Kleij D,Nurmohamed MT,van der Horst-Bruinsma IE,Rispens T,Wolbink GJ

更新日期：2015-10-01 00:00:00

abstract：:The aetiology of Reiter's syndrome (RS) is unknown. In order to evaluate the role of immunological mechanisms in this disease we performed synovial biopsies on 12 patients with RS looking for deposition of immunoglobulins and complement components in synovial tissue. By immunofluorescent techniques 11 synovia were fou...

journal_title：Annals of the rheumatic diseases

authors： Baldassare AR,Weiss TD,Tsai CC,Arthur RE,Moore TL,Zuckner J

更新日期：1981-06-01 00:00:00

abstract：OBJECTIVE:To investigate the association of a recently described classification of Human leukocyte antigen (HLA)-DRB1 shared epitope alleles with rheumatoid factors (RF) and anti-cyclic citrullinated peptide (CCP) production and radiological severity in rheumatoid arthritis (RA). METHODS:Patients with RA (n = 962) wer...

journal_title：Annals of the rheumatic diseases

authors： Mewar D,Marinou I,Coote AL,Moore DJ,Akil M,Smillie D,Dickson MC,Binks MH,Montgomery DS,Wilson AG

更新日期：2008-07-01 00:00:00