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Lung transplantation in young infants with interstitial pneumonia.

Abstract：

OBJECTIVES:We describe our experience with infants suffering from interstitial pneumonia referred for lung transplantation. METHODS:From April 1998 to December 2000, three infants were admitted to our lung transplantation program: a 9-month-old girl (patient 1) suffering from surfactant protein C deficiency who had high oxygen requirements (fraction of inspired oxygen: 70% to 90%), and two boys, ages 2 (patient 2) and 9 months (patient 3), who were ventilator-dependent due to chronic pneumonitis of infancy. RESULTS:Patients were transplanted at the age of 5 months (patient 2) and 13 months (patients 1 and 3) at 87 to 105 days after being accepted for lung transplantation. All cases underwent a sequential double lung transplant on cardiopulmonary bypass. The immunosuppressive regime included tacrolimus, prednisone, and azathioprine. Patients 2 and 3 also received basiliximab. Two cases suffered a mild rejection episode that responded to high-dose steroids. Patient 2 was ventilator-dependent for 8 months after transplant, owing to severe bronchomalacia and left main bronchus stenosis. Bronchial stenosis resolved after pneumatic dilatation and endobronchial stenting. This patient also presented with a pulmonary artery anastomosis stricture that required percutaneous balloon dilatation. All three patients are at home, carrying out normal activities for their age, with no respiratory symptoms after a period of 8 to 29 months of follow-up. CONCLUSIONS:Interstitial pneumonia of infancy is a rare disease with a bad prognosis and no specific treatment; therefore, lung transplantation represents a good therapeutic option for these infants.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Moreno A,Maestre J,Balcells J,Marhuenda C,Cobos N,Roman A,Soler J,Montferrer N,Liñan S,Gartner S,Roqueta J,Majo J

doi

10.1016/s0041-1345(03)00665-1

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

1951-3

issue

5

eissn

0041-1345

issn

1873-2623

pii

S0041134503006651

journal_volume

35

pub_type

杂志文章

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