Abstract:
OBJECTIVES:To investigate, by real-time quantitative reverse transcriptase-polymerase chain reaction, the expression of MUC3 and vascular endothelial growth factor (VEGF) to correlate them with histologic parameters and with prognosis. Human mucins are large O-glycoproteins expressed in epithelial tissues. Deregulation of mucin genes has been demonstrated in several epithelial neoplasms. In the kidney, MUC3 is expressed in normal convoluted tubules and in renal clear cell carcinoma. METHODS:Twenty-six renal clear cell carcinoma specimens were studied. For all tumors, samples of normal and tumor kidney were frozen. After RNA extraction, using ultracentrifugation through a cesium chloride cushion, VEGF and MUC3 mRNA were analyzed by real-time quantitative reverse transcriptase-polymerase chain reaction. The pathologic parameters included Fuhrman nuclear grade and TNM stage. All follow-up data were available. RESULTS:The median level of MUC3 and VEGF expression was greater in tumor areas compared with normal areas (P < 0.002 and P < 0.001, respectively). The MUC3 tumor/normal tissue expression ratio was greater in nuclear grade 3 tumor than in low grades (grade 1-2; P < 0.005). No statistically significant relationship was found with the prognosis for MUC3 and VEGF in our study. CONCLUSIONS:The results of this study demonstrate that MUC3 and VEGF are overexpressed in renal clear cell carcinoma, and the MUC3 expression ratio is greater in nuclear grade 3 than in grades 1 and 2 (low grades) tumor. These findings suggest the implication of MUC3 in renal carcinogenesis.
journal_name
Urologyjournal_title
Urologyauthors
Leroy X,Gouyer V,Ballereau C,Zerimech F,Huet G,Copin MC,Aubert JP,Porchet Ndoi
10.1016/s0090-4295(03)00560-0subject
Has Abstractpub_date
2003-10-01 00:00:00pages
771-5issue
4eissn
0090-4295issn
1527-9995pii
S0090429503005600journal_volume
62pub_type
杂志文章相关文献
UROLOGY文献大全abstract::Mesoblastic nephroma is the most common solid renal neoplasm in the first few months of life. It has been recognized only recently as a distinct entity, having been classified previously as Wilms tumor. There are relatively few ultrasonic descriptions of this entity in the literature. We present an additional case fea...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(82)90590-8
更新日期:1982-02-01 00:00:00
abstract::Approximately 5% of all urothelial tumors in adults arise from the upper tracts. While the gold standard treatment is open nephroureterectomy, laparoscopic nephroureterectomy is becoming increasingly popular. Oncologic principles dictate that complete excision of the transmural ureter and bladder cuff and avoidance of...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2008.04.022
更新日期:2008-11-01 00:00:00
abstract::Three new cases of a rare benign proliferative lesion of the urothelium (nephrogenic adenoma) are hereby added to the existent 58 reported cases. All 3 lesions occurred in the bladder. Two of the 3 cases presented with a history of surgical interventions on the bladder, and the third patient had a history of chronic c...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(85)90169-4
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVES:The maximal effect of transurethral microwave thermotherapy (TUMT) for lower urinary tract symptoms (LUTS) of benign prostatic hyperplasia (BPH) occurs 3 to 6 months after treatment. In the acute period after TUMT, little change in symptoms, quality of life (QOL), and peak urinary flow rate (Qmax) is observe...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)00029-1
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of a weekly oral cycling antibiotic (WOCA) strategy to prevent UTI in women. MATERIALS AND METHODS:We performed a monocentric, comparative, retrospective, cross-sectional study on pregnant women under clean intermittent self catheterization between January 2008 and December ...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2016.02.007
更新日期:2016-05-01 00:00:00
abstract::Closure of laparoscopic trocar sites can be difficult, particularly in the obese patient. We have begun using a spring-loaded needle to facilitate closure of these sites. We have found that the device allows for accurate suture placement, the potential of decreased closure time, reduced risk for trocar site dehiscence...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(95)80023-9
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVES:An association between prostatitis and male infertility has been suspected, yet is poorly understood. Prostatitis is often associated with granulocytes in the prostatic fluid that generate reactive oxygen species (ROS), known to impair male fertility. We compared ROS, the total antioxidant capacity (TAC), an...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)00613-5
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVES:To explore the mechanism for the differing nuclear morphometric results between needle biopsy and surgical specimens of the prostate. METHODS:In experiment 1, a comparison of mean nuclear area (MNA), volume-weighted mean nuclear volume (MNV), and form factor (FF) for prostatic epithelial cells was performed...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(00)00583-5
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the complication rate intraoperatively and within the first 30 postoperative days of the pubovaginal sling procedure. METHODS:From January 1992 to September 1996, we prospectively analyzed 90 women with type II and III genuine stress incontinence (age 38 to 84 years, average Valsalva leak point ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(99)00387-8
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:The use of polytetrafluoroethylene (PTFE) paste in the lower urinary tract for the treatment of vesicoureteral reflux or urinary incontinence is increasing. Its use remains controversial and the long-term consequence of this substance injected into the lower urinary system of humans is largely unknown. When i...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(94)90149-x
更新日期:1994-06-01 00:00:00
abstract::Because of the high incidence of lower pole reflux in complete duplications, decreased, delayed, or absent function in a hydronephrotic lower pole moiety is usually initially attributed to reflux nephropathy. Obstruction occurs commonly in the upper pole moiety due to an ectopic ureteral orifice or ureterocele. Howeve...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(85)90268-7
更新日期:1985-07-01 00:00:00
abstract::Ureterocystoplasty enables the bladder to be reliably enlarged and the resultant neobladder to be lined by urothelium. Many techniques have been described for the operative management of the lower ureter, and a number of alternatives have been suggested for reconstruction of the upper renal tract and bladder. This rep...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(98)00363-x
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:To present a case of laparoendoscopic single-site surgery (LESS) nephroureterectomy (NUx), a type of embroyonic natural orifice translumenal endoscopic surgery, which is one of the recent innovations in the era of laparoscopy, in a child. METHODS:A 10-year-old girl underwent left nephroureterectomy by LESS d...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.05.096
更新日期:2009-11-01 00:00:00
abstract::Leiomyosarcomas arising from the renal vein are rare tumors: only 13 cases are found in the literature. We report a case in a sixty-one-year-old woman who presented with back pain and hematuria. She underwent resection of the tumor and an ipsilateral nephrectomy. The tumor recurred locally, and the patient died thirty...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/s0090-4295(91)80358-e
更新日期:1991-09-01 00:00:00
abstract:OBJECTIVES:To evaluate the long-term outcomes of penile prosthesis surgery at a teaching institution. METHODS:Patients who had penile prosthesis surgery from 1988 to 1999 at a private teaching hospital and the Dallas Veterans Affairs Medical Center were identified and charts abstracted for age at first prosthesis, eth...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/s0090-4295(03)00665-4
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVES:To evaluate and compare the safety and effectiveness of two noncontact laser regimens for the treatment of human benign prostatic hyperplasia (BPH), and to assess the impact of the spatial distribution of the laser-induced lesions on treatment outcome. METHODS:This was a prospective, double-blind, randomize...
journal_title:Urology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0090-4295(99)80084-3
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVES:Studies suggest obesity is associated with decreased prostate cancer risk. We hypothesized obesity is biologically associated with increased risk, although this is obscured owing to hemodilution of prostate-specific antigen (PSA) and larger prostate size. METHODS:We retrospectively studied 441 consecutive m...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.05.044
更新日期:2008-11-01 00:00:00
abstract::A 20-year-old man with Stage II nonseminomatous germ cell tumor underwent chemotherapy and multiple surgical resections of recurrent abdominal and supradiaphragmatic mature teratomas. Evaluation of a new heart murmur led to the diagnosis of tricuspid valve teratoma, which required complete valve excision and replaceme...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/s0090-4295(00)00578-1
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVE:To investigate whether 1-adrenoceptor signaling in the human prostate involves regulation of the mitogen-activated protein kinase (MAPK) p38. Although α1-adrenoceptors are an important target for therapy of lower urinary tract symptoms in patients with prostate hyperplasia, intracellular signaling by prostate...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2011.03.036
更新日期:2011-10-01 00:00:00
abstract::A new technique for microvascular anastomosis of the polar artery to the renal artery, end to side, is presented. It was performed in 5 cases of renal transplantation with a successful result in all. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(75)90808-0
更新日期:1975-12-01 00:00:00
abstract::Testicular tumors are found in approximately 2 per 100,000 population. An extremely rare occurrence of synchronous testicular tumor in identical twins is presented. A complete review of the world literature with regard to testes tumors in brothers and twins is also given. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(75)90814-6
更新日期:1975-12-01 00:00:00
abstract:OBJECTIVES:To examine changes in testosterone levels in the cavernous and peripheral blood during different phases of erection because, although the determination of systemic testosterone levels has been well established in the diagnostic workup of erectile dysfunction, the exact role of testosterone in adult male sexu...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(00)00551-3
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVES:To evaluate the chronologic changes in the International Prostate Symptom Score (IPSS), uroflowmetric parameters, and prostate volume (PV) in patients who received low-dose-rate brachytherapy. METHODS:Between July 2004 and December 2006, 110 patients received low-dose-rate brachytherapy. Of the 110 patients...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.12.062
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:Most adenocarcinomas of the prostate with a Gleason score greater than 8 at radical prostatectomy have extraprostatic extension and a high risk of progression. With prostate-specific antigen screening, we have seen some cases of earlier detected, organ-confined, high-grade adenocarcinoma. Few data are availa...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(02)01816-2
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:To investigate the effects of Uro-Vaxom, an oral vaccine against Escherichia coli urinary tract infections, on human monocyte-derived dendritic cells (moDCs). Dendritic cells (DCs) are important antigen-presenting cells of the immune system. DCs are considered promising cellular adjuvants for inducing immuni...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(02)01767-3
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the impact of frailty on adverse perioperative outcomes in patients treated with radical cystectomy for bladder cancer. MATERIAL AND METHODS:We identified 9459 adults (age ≥18) in the Nationwide Readmission Database who underwent radical cystectomy in 2014 for bladder cancer. We defined patients'...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2019.04.057
更新日期:2019-11-01 00:00:00
abstract::Evidence relating to the perception and view of patients and physicians on natural orifice transluminal endoscopic surgery (NOTES) and laparoendoscopic single-site surgery (LESS) was scrutinized. A comprehensive literature search was performed through PubMed. A total of 18 studies were included in the analysis. Patien...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2012.04.002
更新日期:2012-09-01 00:00:00
abstract::Retrograde pyelography to demonstrate the renal pelvis and ureters is a common urologic procedure. Newer contrast materials and better radiographic techniques have obviated many of the previous indications for retrograde studies were independently reviewed by two urologists and a radiologist to determine if the studie...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(79)90196-1
更新日期:1979-11-01 00:00:00
abstract::Two cases of urinary obstruction secondary to neoplastic involvement of the prostate from abdominal-perineal resection for carcinoma of the rectosigmoid are discussed. A review of the literature and the management of this infrequent entity is described. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(75)90729-3
更新日期:1975-08-01 00:00:00
abstract::Spontaneous perforation complicating augmentation cystoplasty is reported to occur in ≤ 13% of cases. The standard treatment is open surgical repair of the perforation. To our knowledge, this is the first report of laparoscopic repair of a perforated augmentation cystoplasty. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2012.10.033
更新日期:2013-02-01 00:00:00