Abstract:
OBJECTIVES:Most adenocarcinomas of the prostate with a Gleason score greater than 8 at radical prostatectomy have extraprostatic extension and a high risk of progression. With prostate-specific antigen screening, we have seen some cases of earlier detected, organ-confined, high-grade adenocarcinoma. Few data are available as to the likelihood of cure in these cases. METHODS:We reviewed 27 cases of pathologically organ-confined adenocarcinoma with a prostatectomy Gleason score of 8 to 10. To exclude cases with a significant proportion of Gleason pattern 3, we excluded cases of Gleason score 3+5=8 and Gleason score 5+3=8. All cases of Gleason score 8 at radical prostatectomy were Gleason score 4+4. The prognostic value of the clinical parameters (clinical stage, serum prostate-specific antigen level, age) and pathologic factors (biopsy Gleason score, radical prostatectomy Gleason score, prostatectomy tumor volume) were tested to predict postoperative progression. RESULTS:The mean age at diagnosis was 59.7 years (range 46 to 69) with preoperative serum prostate-specific antigen levels ranging from 1.4 to 28 ng/mL (mean 7.8). All tumors were classified as pathologic Stage T2N0Mx. Fifteen patients (55.6%) had a Gleason score of 8, 11 patients (40.7%) had a Gleason score of 9, and 1 had a Gleason score of 10 (3.7%). Tumor volumes ranged from 0.02 to 1.44 cm(3) (mean 0.56). Follow-up information was available for all men. The mean follow-up for those without progression was 30.6 months (range 7 to 73) and for those with progression was 23.6 months (range 9 to 44). The 33-month actuarial risk of progression was 32%, with 10 men developing progression during the study. None of the preoperative or postoperative variables predicted progression. CONCLUSIONS:Even when high-grade tumor is organ confined, it is associated with a relatively unfavorable short-term outcome that is not predictable on the basis of either preoperative clinicopathologic data or postoperative pathologic information obtained from the radical prostatectomy specimen.
journal_name
Urologyjournal_title
Urologyauthors
Rioux-Leclercq NC,Chan DY,Epstein JIdoi
10.1016/s0090-4295(02)01816-2subject
Has Abstractpub_date
2002-10-01 00:00:00pages
666-9issue
4eissn
0090-4295issn
1527-9995pii
S0090429502018162journal_volume
60pub_type
杂志文章相关文献
UROLOGY文献大全abstract:OBJECTIVE:To investigate the cognitive and physical workload experienced by each operating room team member for different types of urologic procedures. METHODS:Surgeons, anesthesiologists, surgical fellows, bedside assistants, circulating nurses, and scrub nurses completed the National Aeronautics and Space Administra...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2017.05.012
更新日期:2017-09-01 00:00:00
abstract::Calcifications of the kidney may be located free within the collecting system, attached to a papilla, trapped beneath the urothelium, or sequestered in the renal parenchyma. Extracorporeal shock wave lithotripsy has failed to render patients who presented with nephrocalcinosis stone free because of the submucosal loca...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(00)00675-0
更新日期:2000-09-01 00:00:00
abstract::Vas irrigation during vasectomy, to effect immediate sterility or to shorten the interval between vasectomy and sterility, has received increasing attention in recent years. A review of the literature on vas irrigation is presented. Topics discussed include the effectiveness of various irrigants and irrigation methods...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/0090-4295(79)90173-0
更新日期:1979-11-01 00:00:00
abstract::The experience gained from the implantation of 763 Flexirod Prosthesis is described. Special features of this design include a tapered distal tip which provides for better glans stability, a soft hinge which allows for improved penile concealment, and a trimmable tail which, together with preoperative measurement of t...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(84)90247-4
更新日期:1984-05-01 00:00:00
abstract::Because tissue samples obtained ureteroscopically are small, the techniques for biopsy and for handling and processing the samples are crucial. Our aim is to describe the biopsy technique in great detail so other centers can reproduce it. Patients were evaluated by retrograde ureteropyelography and ureteroscopy for di...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/S0090-4295(97)00216-1
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVES:To review the feasibility and outcome of retroperitoneoscopic nephrectomy (RPN) for pyonephrotic nonfunctioning kidneys. METHODS:RPN for pyonephrotic nonfunctioning kidneys was used in 52 patients from July 2001 to May 2007. Percutaneous nephrostomy drainage was instituted in 46 patients because of sepsis b...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.07.054
更新日期:2010-03-01 00:00:00
abstract::The interim findings of two studies of intravenous ofloxacin for the treatment of pyelonephritis are presented. The findings are from one center of a multicenter trial. In the first study intravenous (IV) ofloxacin was given to 34 patients with urine-culture-positive pyelonephritis. After three days of intravenous the...
journal_title:Urology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/0090-4295(91)80091-k
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:To determine the best preventive strategies for bladder calculi in children with an augmented bladder, the risk factors and prevention strategies for urolithiasis were evaluated. METHODS:The records of 89 patients following augmentation cystoplasty were reviewed to assess the results of augmentation cystopl...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(00)00663-4
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVES:The metallothioneins (MTs) are a family of small molecular weight trace metal and free radical scavenging proteins well established to play a role in the resistance to chemotherapy and radiotherapy in human cancers. MT gene expression is upregulated in response to the presence of metal ions such as zinc. Bec...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.12.032
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:To determine the probability of visible hematuria with antithrombotic agents and to evaluate association of urologic etiology in antithrombotic-related hematuria. METHODS:Preferred Reporting Items in Systematic Reviews and Meta-Analyses guidelines were followed to conduct a systematic review using search eng...
journal_title:Urology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.urology.2017.11.023
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:To estimate the disease-specific survival of patients with complete removal of the seminal vesicles (SVs) at radical prostatectomy and to develop a nomogram for the prediction of SV invasion (SVI). METHODS:An analysis of 6740 patients from three institutions was performed. The primary outcome was biochemica...
journal_title:Urology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.urology.2006.12.013
更新日期:2007-03-01 00:00:00
abstract::Five cases of anterior urethral diverticula with resulting anterior urethral valves are reported. All children presented with a poor stream. Diagnosis was accomplished by voiding cystourethrography, and treatment was by open resection of the diverticulum in four neonates and endoscopic excision of the valve in a four-...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(87)90382-7
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVES:To evaluate prospectively the success of scrotal incision orchiopexy (Bianchi technique) with or without inguinal hernia in patients with an undescended testis within the inguinal canal or beyond the external inguinal ring. METHODS:A total of 72 orchiopexies were performed in 56 patients with a primary unde...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2004.06.069
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVES:To evaluate the clinical utility of transrectal ultrasound-guided systematic sextant needle biopsies in the prediction of extracapsular extension (ECE) at radical prostatectomy. METHODS:A retrospective analysis of 104 men who underwent systematic biopsy and radical prostatectomy at our institution was perfo...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/S0090-4295(97)00240-9
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVES:The combined use of total prostate-specific antigen (PSA), clinical stage, and Gleason score accurately predicts final pathologic stage for men with clinically localized prostate cancer. Recently, the free/ total PSA ratio has been proposed as an adjunct for early detection of prostate cancer. We examined th...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(96)00610-3
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVES:Complete and reliable infiltration of the entire prostate is important to improve the efficacy of intraprostatic gene therapy, as well as drug delivery. We sought to evaluate the optimal injection scheme and feasibility of magnetic resonance imaging (MRI) using a surrogate solution to assess the distribution...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.06.637
更新日期:2007-10-01 00:00:00
abstract::Large-burden bladder stones often require percutaneous cystolithotomy or an open procedure. These approaches may not be feasible in certain patients who are at increased risk of operative complications. We present a novel technique for transurethral cystolitholapaxy using Amplatz sheath in the male urethra. ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2004.07.022
更新日期:2004-11-01 00:00:00
abstract::Angiomyolipoma is a benign renal tumor that tends to grow with time and can be associated with complications, such as hemorrhage and pain, requiring active intervention. Nephron-sparing surgery for sporadic renal angiomyolipomas offers preservation of renal function and is associated with acceptable complication and r...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2009.02.051
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:To characterize the changes in urine composition associated with increasing severity of diabetes, we analyzed urine composition relative to glycated hemoglobin (HbA1c) and treatment strategy in a largely minority population. METHODS:Patients treated for kidney stones between 2001 and 2013 at a single tertiar...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2015.10.013
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:To propose a clinical phenotype system (urinary, psychosocial, organ specific, infection, neurologic/systemic, and tenderness [UPOINT]) to classify patients with urologic pelvic pain to help understand the etiology and guide therapy. We wished to validate this system in men with chronic pelvic pain syndrome ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2008.09.074
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To present our experience of vaginal reconstruction in female cloacal exstrophy patients. PATIENTS AND METHODS:The records of 7 postpubertal female cloacal exstrophy patients (median age, 17 years; range, 11-26 years) were retrospectively reviewed. Complete duplication of the uterus and vagina was noted in a...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2014.05.042
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:To determine the safety and efficacy of transurethral electrovaporization of the prostate (TVP) in men with lower urinary tract symptoms. METHODS:A prospective trial of 114 consecutive patients who underwent TVP since August 1994 was conducted. The mean follow-up period was 12.3 months. Parameters evaluated...
journal_title:Urology
pub_type: 临床试验,杂志文章
doi:10.1016/s0090-4295(96)00487-6
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVES:To evaluate the effectiveness and safety of a new purified collagen gel with specific properties for renal artery embolization in an experimental model in dogs. METHODS:The new gel was prepared from type I bovine tendon collagen, highly purified to eliminate immunogenicity, and reconstituted through extensi...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2005.10.043
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:To investigate the weak correlation between bladder outlet obstruction (BOO), as diagnosed using the provisional International Continence Society nomogram for the definition of BOO in men, and postvoid residual urine volume. METHODS:The relationship between voiding to completion and several indexes for blad...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(03)00575-2
更新日期:2003-10-01 00:00:00
abstract::This paper is one-half of a 2 part review on minimally-invasive procedures in pediatric urology. This article focuses on lower tract procedures, including ureteroureterostomy, anti-reflux surgeries, creation of continent catheterizable channels, and augmentation cystoplasty. We note important articles on pure laparosc...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/j.urology.2009.11.073
更新日期:2010-07-01 00:00:00
abstract::Prostate cancer is dependent on androgen stimulation mediated by the androgen receptor (AR), a member of the steroid hormone receptor family of ligand-dependent nuclear receptors. Most patients respond to standard androgen ablation therapies, but virtually all patients eventually relapse with disease that has been ter...
journal_title:Urology
pub_type: 杂志文章,评审
doi:10.1016/s0090-4295(02)01593-5
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To study the use of a baseline prostate-specific antigen (PSA) and digital rectal examination in men (aged 40-49 years) in predicting long-term prostate cancer risk in a prospectively followed, representative population cohort. PATIENTS AND METHODS:Since 1990, a random sample of men in Olmsted County (aged 4...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2013.06.074
更新日期:2013-12-01 00:00:00
abstract::A patient with a durable, complete, local and pulmonary remission of a metastatic sarcomatoid carcinoma of the bladder treated with gemcitabine and cisplatin is presented. Sarcomatoid carcinoma arising in the bladder is a rare and notoriously aggressive variant of urothelial carcinoma for which an effective systemic t...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/s0090-4295(01)01343-7
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVES:To compare different tools for evaluate prostate-specific antigen (PSA) kinetics before prostate biopsy, such as PSA velocity, PSA slope, natural logarithm PSA slope (lnPSA slope), and PSA doubling time (PSADT). METHODS:This study was conducted involving 325 male patients evaluated with transrectal ultrasou...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/j.urology.2007.10.021
更新日期:2008-03-01 00:00:00
abstract::We investigated the effectiveness of intravesically administered drugs on the tumor incidence and tumor size in a FANFT-induced animal model for bladder cancer. In the first experiment 106 C3H/He mice were divided into a control and three treatment groups. Therapy consisted of either cis-diamminedichloroplatinum (II) ...
journal_title:Urology
pub_type: 杂志文章
doi:10.1016/0090-4295(82)90574-x
更新日期:1982-02-01 00:00:00