Site-specific DNA cleavage by Cu(II) complexes of podophyllotoxin derivatives.

abstract：:The peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors involved in lipid metabolism and glucose utilization, in cell growth, differentiation and apoptosis, and in the regulation of pro-inflammatory genes expression such as cyclooxygenase-2 (COX-2). PPARγ is the main isoform ...

journal_title：Biochemical pharmacology

authors： Casali CI,Weber K,Faggionato D,Gómez EM,Tome MC

更新日期：2014-08-15 00:00:00

abstract：:Previous reports have indicated that insulin administration triggers an early increase in plasma tryptophan (TRP) levels in fasted rats. Then, the present study was undertaken to investigate the putative role of liver tryptophan pyrrolase (TPO) in this short-term effect of insulin. In 24 hr fasted rats, doses of insul...

journal_title：Biochemical pharmacology

authors： Broqua P,Baudrie V,Laude D,Guezennec Y,Chaouloff F

更新日期：1990-08-15 00:00:00

abstract：:The extraction and partial purification of endogenous "monoamine oxidase (MAO) inhibitor-like" material from the monkey brain are described. The endogenous material (F-1 and F-2) obtained after Bio-Gel P-2 gel filtration and silica column chromatography inhibited MAO in the monkey brain mitochondria toward 5-hydroxytr...

journal_title：Biochemical pharmacology

authors： Egashira T,Obata T,Nagai T,Kimba Y,Takano R,Yamanaka Y

更新日期：1989-02-15 00:00:00

abstract：:Phenylbutazone (PBZ) is known to inhibit the oriented migration of human polymorphonuclear leukocytes (PMNs) induced by formyl-methionyl-leucyl-phenylalanine (FMLP), and to protect these cells against the deactivation caused by their prior incubation with FMLP. To gain insight into the mechanism of these effects, we m...

journal_title：Biochemical pharmacology

authors： Perianin A,Labro MT,Hakim J

更新日期：1982-10-01 00:00:00

abstract：:As previously shown with isolated oxyhemoglobin, methemoglobin formation can also be induced in intact erythrocytes by hydroxylamine compounds and substituted phenols such as butylated hydroxyanisole (BHA). Electron spin resonance investigations revealed that, accordingly, free radical intermediates were formed in ery...

journal_title：Biochemical pharmacology

authors： Stolze K,Dadak A,Liu Y,Nohl H

更新日期：1996-12-24 00:00:00

abstract：:The uptake of iron by the liver and cerebellum was measured in rats using [59Fe]transferrin. An acute ethanol load (50 mmol/kg body wt., i.p.) elicited a significant increase in the hepatic and cerebellar non-heme iron concentration. The uptake of 59Fe by the liver and the cerebellum was significantly greater in the e...

journal_title：Biochemical pharmacology

authors： Rouach H,Houze P,Gentil M,Orfanelli MT,Nordmann R

更新日期：1994-05-18 00:00:00

abstract：:Carbamazepine is an anticonvulsant which is associated with a significant incidence of hypersensitivity reactions including agranulocytosis. We have postulated that many drug hypersensitivity reactions, especially agranulocytosis and lupus, are due to reactive metabolites generated by the myeloperoxidase (MPO) (EC 1.1...

journal_title：Biochemical pharmacology

authors： Furst SM,Uetrecht JP

更新日期：1993-03-24 00:00:00

abstract：:The adverse effects of smoking during pregnancy on fetal development are, in part, due to nicotine. These effects may be due to the actions of nicotine in fetal circulation or on placental functions. In pregnant rats, vaccination with a nicotine immunogen reduces the transfer of nicotine from the maternal to fetal cir...

journal_title：Biochemical pharmacology

authors： Nekhayeva IA,Nanovskaya TN,Pentel PR,Keyler DE,Hankins GD,Ahmed MS

更新日期：2005-11-25 00:00:00

abstract：:Thioredoxin reductase (TR1) is a selenoprotein that is involved in cellular redox status control and deoxyribonucleotide biosynthesis. Many cancers, including lung, overexpress TR1, making it a potential cancer therapy target. Previous work has shown that TR1 knockdown enhances the sensitivity of cancer cells to antic...

journal_title：Biochemical pharmacology

authors： Poerschke RL,Moos PJ

更新日期：2011-01-15 00:00:00

abstract：:The elimination and metabolism of a single dose (100 mg/kg) of 2,4-dinitrotoluene (2,4-DNT) in A/J mice were examined. After intraperitoneal administration, elimination was rapid, with 70% of the dose appearing in the urine within 4 hr. Four hours after oral administration, only 28.5% of the dose was excreted in the u...

journal_title：Biochemical pharmacology

authors： Schut HA,Dixit R,Loeb TR,Stoner GD

更新日期：1985-04-01 00:00:00

abstract：:The interaction of sanguinarine iminium form (structure I) and sanguinarine alkanolamine form (structure II) with calf thymus DNA has been studied in buffer of pH 5.2 and pH 10.5, respectively, where the physicochemical properties of DNA remain unchanged. The binding of sanguinarine iminium form to DNA is characterize...

journal_title：Biochemical pharmacology

authors： Sen A,Maiti M

更新日期：1994-11-29 00:00:00

abstract：:Aldehydes generated during radical-induced lipid peroxidation, in particular 4-hydroxynonenal, are known to inhibit growth of certain cells. To extend our arguments that free radicals might be involved in the host response against malaria parasites we tested 26 carbonyls (n-alkanals, C6-C11; 2-alkenals, C3-C9; 2,4-alk...

journal_title：Biochemical pharmacology

authors： Clark IA,Butcher GA,Buffinton GD,Hunt NH,Cowden WB

更新日期：1987-02-15 00:00:00

abstract：:Inhibition of glycogen synthase kinase (GSK)-3 and the consequent activation of the Wnt/β-catenin signaling pathway have been reported to increase bone volume. To develop a novel pharmacotherapy for injured bone, we investigated whether GSK-3 inhibitor was effective in promoting bone formation. In in vitro experiments...

journal_title：Biochemical pharmacology

authors： Arioka M,Takahashi-Yanaga F,Sasaki M,Yoshihara T,Morimoto S,Hirata M,Mori Y,Sasaguri T

更新日期：2014-08-15 00:00:00

abstract：:N-Butyldeoxynojirimycin (NB-DNJ) inhibits the ceramide glucosyltransferase which catalyses the first step in glycosphingolipid (GSL) biosynthesis. It has the potential to be used for the treatment of the GSL lysosomal storage diseases and is currently in clinical trials for the treatment of type 1 Gaucher's disease. H...

journal_title：Biochemical pharmacology

authors： Andersson U,Butters TD,Dwek RA,Platt FM

更新日期：2000-04-01 00:00:00

abstract：:The mechanisms by which amiloride and 4,4'-diisothiocyano-2,2'-disulfonic stilbene (DIDS) inhibit hepatic uptake of cholate and taurocholate (TC) were investigated in isolated rat hepatocytes. Amiloride inhibited Na(+)-dependent uptake of cholate and TC only when hepatocytes were preincubated with amiloride, indicatin...

journal_title：Biochemical pharmacology

authors： Anwer MS,Branson AU,Atkinson JM

更新日期：1991-12-11 00:00:00

abstract：:Adenosine is an endogenous nucleoside that regulates many physiological processes through the activation of its four receptors: A(1), A(2A), A(2B) and A(3). Previous studies have identified the involvement of A(2) receptors in the inhibitory activity of adenosine analogues on tumor necrosis factor-alpha (TNF-alpha) pr...

journal_title：Biochemical pharmacology

authors： Zhang JG,Hepburn L,Cruz G,Borman RA,Clark KL

更新日期：2005-03-15 00:00:00

abstract：:The effects of thiamine thiazolone (TT) and thiamine thiazolone pyrophosphate (TTPP) on the in vitro and in vivo inhibition of pyruvate dehydrogenase complex (PDHC) from rat cortex and hippocampus were characterized. TTPP decreased PDHC activity in vitro but had no effect in vivo following its direct chronic administr...

journal_title：Biochemical pharmacology

authors： Kandiko CT,Smith D,Yamamoto BK

更新日期：1988-11-15 00:00:00

abstract：:Despite the steadily increased numbers of formyl peptide receptor (FPR) ligands identified over the years, few have been characterized in studies using animal disease models and even less have entered clinical trials in human subjects. A small-molecule compound, Act-389949, was however recently tested in a phase I cli...

journal_title：Biochemical pharmacology

authors： Lind S,Sundqvist M,Holmdahl R,Dahlgren C,Forsman H,Olofsson P

更新日期：2019-08-01 00:00:00

abstract：:The role of Na(+) and Na(+) exchangers in intracellular Ca(2+) elevation and leukotriene B(4) (LTBs) formation was investigated in granulocyte macrophage colony-stimulating factor (GM-CSF)-primed, fMLP-stimulated human neutrophils. Isotonic substitution of extracellular Na(+) with N-methyl-D-glucamine(+) (NMDG(+)) res...

journal_title：Biochemical pharmacology

authors： Tedeschi A,Ciceri P,Zarini S,Lorini M,Di Donato M,Nicosia S,Miadonna A,Sala A

更新日期：2004-01-15 00:00:00

abstract：:The inactive anthracycline analog 4-demethoxy-7,9-di-epi-daunorubicin was covalently coupled to polyglutaraldehyde microspheres. The polymer-bound analog acquired significant cytostatic activity as evaluated with doxorubicin resistant and sensitive murine L1210 leukemia cells. A suggested multiple membrane interaction...

journal_title：Biochemical pharmacology

authors： Rogers KE,Tökés ZA

更新日期：1984-02-15 00:00:00

abstract：:The binding of phenylbutazone (PB) to human serum albumin (HSA) at different pH and in the presence of different NaSCN and urea concentrations that alter the conformation of the protein was examined qualitatively on the basis of extrinsic elliptical strength at 288 nm by means of circular dichroism (CD). The values of...

journal_title：Biochemical pharmacology

authors： Watanabe S,Saito T

更新日期：1992-03-03 00:00:00

abstract：:The interaction of various cholecystokinin (CCK) peptides with the protein inhibitor (PK-I) of cyclic AMP dependent protein kinase (A-PK) has been studied. The order of the affinities (ED50) for relaxation of hog biliary muscle by a series of C-terminal peptides of CCK correlated with the order of the potencies for A-...

journal_title：Biochemical pharmacology

authors： Kimura M,Kobayashi S,Kimura I

更新日期：1983-03-01 00:00:00

abstract：:The cytoprotective effects of propylthiouracil (PTU) were studied in rats treated with the hepatotoxin D-galactosamine (D-GNH2). Five days of PTU pretreatment prior to D-GNH2 caused hypothyroidism and a significant reduction in liver injury as assessed by serum transaminase levels. When PTU was administered as a singl...

journal_title：Biochemical pharmacology

authors： Cooper DS,Carter EA,Kieffer JD,Wands JR

更新日期：1984-11-01 00:00:00

abstract：:A form of cytochrome P-450, P-450-D3, cross reactive with antibodies to rat P-450d was purified from liver microsomes of polychlorinated biphenyl (PCB)-treated female Beagle dogs to an electrophoretic homogeneity. Judging from the result of sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS-PAGE), the molec...

journal_title：Biochemical pharmacology

authors： Ohta K,Motoya M,Komori M,Miura T,Kitada M,Kamataki T

更新日期：1989-01-01 00:00:00

abstract：:Although it is generally believed that thiazolidinediones ameliorate insulin resistance by lowering circulating free fatty acids, direct effects of these drugs in skeletal muscle may also contribute to their antidiabetic action. We report that troglitazone administration to mice for 1 day increased the protein express...

journal_title：Biochemical pharmacology

authors： Planavila A,Alegret M,Sánchez RM,Rodríguez-Calvo R,Laguna JC,Vázquez-Carrera M

更新日期：2005-04-15 00:00:00

abstract：:The microsomal brush-border fraction of rat renal tissue contains enzymatic activity, optimally active at pH 9, that is capable of degrading human myelin basic protein (BP) peptide 43-88. In the present study, this degradation and the effect on it of selected drugs and hormones were examined further. Of the substances...

journal_title：Biochemical pharmacology

authors： Trestman RL,Heinemann MA,Whitaker JN,Seyer JM

更新日期：1985-04-15 00:00:00

abstract：:What does it mean to be a mentor in science? Definitions of mentorship are freely spouted in publications and include concepts such as academic support, professional development, role modeling, interaction, impartment of knowledge, evaluation of work, demonstration of methodology, etc. Perhaps most of us would agree w...

journal_title：Biochemical pharmacology

authors： Smith SL

更新日期：2015-11-15 00:00:00

abstract：:Carbon tetrachloride (CCl4)-induced inhibition of very low density lipoprotein (VLDL) secretion was studied in isolated hepatocytes. The hypothesis that inhibition of secretion is due to altered calcium homeostasis following CCl4-dependent inhibition of endoplasmic reticulum calcium sequestration was investigated. Inh...

journal_title：Biochemical pharmacology

authors： Pencil SD,Brattin WJ Jr,Glende EA Jr,Recknagel RO

更新日期：1984-08-01 00:00:00

abstract：:The N-type voltage-gated calcium channel (Ca(v)2.2) functions in neurons to regulate neurotransmitter release. It comprises a clinically relevant target for chronic pain. We have validated a calcium mobilization approach to assessing Ca(v)2.2 pharmacology in two stable Ca(v)2.2 cell lines: alpha1(B), alpha2delta, beta...

journal_title：Biochemical pharmacology

authors： Benjamin ER,Pruthi F,Olanrewaju S,Shan S,Hanway D,Liu X,Cerne R,Lavery D,Valenzano KJ,Woodward RM,Ilyin VI

更新日期：2006-09-14 00:00:00

abstract：:Oleanolic acid (OA) is a natural triperpenoid that protects against a variety of hepatotoxicants such as carbon tetrachloride, cadmium, acetaminophen, and bromobenzene. To gain insight into the molecular mechanisms of this generalized hepatoprotection, genomic analysis was performed on mouse and rat livers after OA tr...

journal_title：Biochemical pharmacology

authors： Liu J,Wu Q,Lu YF,Pi J

更新日期：2008-10-01 00:00:00