Abstract：
:Aldehydes generated during radical-induced lipid peroxidation, in particular 4-hydroxynonenal, are known to inhibit growth of certain cells. To extend our arguments that free radicals might be involved in the host response against malaria parasites we tested 26 carbonyls (n-alkanals, C6-C11; 2-alkenals, C3-C9; 2,4-alkadienals, C7, C9, C10; 4-OH-2-alkenals, C6, C8, C9; 2-alkanones, C3-C9; and malonyldialdehyde) against Plasmodium falciparum in vitro. We had previously detected many of these substances in oxidant-stressed, malaria-infected erythrocytes. Three 2,4-alkadienals (C7, C9 and C10) and three 4-OH-2-alkenals (C6, C8 and C9), at 20-100 microM concentrations, markedly inhibited incorporation of [3H]-hypoxanthine by P. falciparum. Acrolein had low effect, and none of the other compounds (12 aldehydes and 7 ketones) were active at concentrations up to 100 microM. Malonyldialdehyde was without effect at concentrations up to 450 microM. The aldehydes found to be inhibitory against P. falciparum could contribute to both the non-antibody host responses against this parasite and the antimalarial effects of radical-generating compounds such as t-butyl hydroperoxide, hydrogen peroxide, alloxan, isouramil, divicine and primaquine.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Clark IA,Butcher GA,Buffinton GD,Hunt NH,Cowden WBdoi
10.1016/0006-2952(87)90364-9subject
Has Abstractpub_date
1987-02-15 00:00:00pages
543-6issue
4eissn
0006-2952issn
1873-2968pii
0006-2952(87)90364-9journal_volume
36pub_type
杂志文章abstract：:F 11782, or 2',3'-bis-pentafluorophenoxyacetyl-4',6'-ethylidene-beta-D-glucoside of 4'-phosphate-4'-dimethylepipodophyllotoxin 2-N-methyl glucamine salt, a novel dual catalytic inhibitor of topoisomerases I and II, was identified as a potent inhibitor of nucleotide excision repair (NER) by screening procedures using t...
journal_title：Biochemical pharmacology
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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更新日期：1984-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0006-2952(93)90333-r
更新日期：1993-11-02 00:00:00
abstract：:Casein-elicited mouse peritoneal macrophages cultured in the presence of phorbol 12-myristate 13-acetate (PMA) express u-PA. Induction is maximal after 4 hr of stimulation and u-PA activity is mainly recovered with the membrane fraction of the cellular lysate. This enzymatic activity is inhibited by isopropylmethylpho...
journal_title：Biochemical pharmacology
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更新日期：1988-06-01 00:00:00
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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更新日期：1997-08-15 00:00:00
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更新日期：1983-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2011-11-01 00:00:00
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journal_title：Biochemical pharmacology
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更新日期：1983-11-15 00:00:00
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更新日期：2020-12-28 00:00:00
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doi：10.1016/s0006-2952(03)00006-6
更新日期：2003-04-01 00:00:00
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journal_title：Biochemical pharmacology
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更新日期：2010-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.bcp.2005.07.031
更新日期：2005-11-01 00:00:00
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
doi：10.1016/s0006-2952(97)00345-6
更新日期：1998-01-15 00:00:00
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doi：10.1016/j.bcp.2009.09.009
更新日期：2010-02-01 00:00:00
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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journal_title：Biochemical pharmacology
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更新日期：1995-09-07 00:00:00
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更新日期：1985-11-01 00:00:00
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更新日期：2010-10-15 00:00:00
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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更新日期：1991-06-21 00:00:00
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journal_title：Biochemical pharmacology
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更新日期：2013-09-01 00:00:00
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更新日期：2003-05-01 00:00:00
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更新日期：2001-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.bcp.2007.10.010
更新日期：2008-02-15 00:00:00
