Abstract:
:A micellar electrokinetic capillary chromatography method was developed for the separation and determination of aliphatic congeners of bis(amidinohydrazones) in standard solution. Eight bis(amidinohydrazones) could be determined in less than 15 min at an applied voltage of 22 kV, using 0.05 M sodium phosphate as buffer (pH 7.0) together with 1 mM N-cetyl-N,N,N-trimethylammonium bromide. Hydrostatic sample injection was employed. The method exhibited good repeatability and a linear range of 2.5-100 micrograms ml-1. A detection limit of 1 micrograms ml-1 was achieved. The method also allows the determination of bis(amidinohydrazones) in human serum samples.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Lukkari P,Jumppanen J,Jinno K,Elo H,Riekkola MLdoi
10.1016/0731-7085(92)80081-wsubject
Has Abstractpub_date
1992-08-01 00:00:00pages
561-5issue
8eissn
0731-7085issn
1873-264Xpii
0731-7085(92)80081-Wjournal_volume
10pub_type
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