Single breath diffusing capacity for carbon monoxide in stable asthma.


BACKGROUND:Single breath diffusing capacity for carbon monoxide (Dco) is commonly used as a simple method of assessing overall pulmonary gas exchange properties. Studies of Dco in bronchial asthma have yielded conflicting results. OBJECTIVE:To study Dco and to determine the factors influencing Dco in patients with asthma. METHODS:Dco was prospectively measured in 80 consecutive never-smoker patients with uncomplicated stable asthma. The topographic distribution of lung perfusion was determined in 10 asthmatics and 10 controls, with a 133Xe radionuclide scan. RESULTS:The mean (SD) value of Dco was increased to 117 (17) percent of predicted values; individual values were either within or above normal limits; diffusion was also elevated at 116 (19) percent after correction for alveolar volume (transfer coefficient, D/VA). The Dco was not correlated with atopic status, duration of asthma, or results of spirometric tests; there was a weak negative correlation between D/VA and FEV1 or residual volume. There was a better perfusion of the upper zones of the lungs in asthmatics as compared with controls. Among the asthmatics, there was a strong positive correlation between Dco and the apex to base perfusion ratio (r = 0.975). CONCLUSIONS:Dco is normal or high among never smoker patients with uncomplicated asthma; elevated Dco may be attributed to a better perfusion of the apices of teh lungs; the latter could result from two mutually nonexclusive mechanisms: an increase in pulmonary arterial pressure and/or a more negative pleural pressure generated during inspiration as a consequence of bronchial narrowing. The unexpected finding of high Dco should raise the possibility of bronchial asthma in patients with otherwise undiagnosed conditions.






Collard P,Njinou B,Nejadnik B,Keyeux A,Frans A




Has Abstract


1994-05-01 00:00:00
















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    pub_type: 杂志文章,多中心研究


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    authors: Bhagat R,Pant K,Singh VK,Pant C,Gupta A,Jaggi OP

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    pub_type: 临床试验,杂志文章,随机对照试验


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    authors: Drory Y,Ouaknine G,Kosary IZ,Kellermann JJ

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    authors: Kokkarinen J,Tukiainen H,Seppä A,Terho EO

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    authors: Malerba M,Bossoni S,Radaeli A,Mori E,Bonadonna S,Giustina A,Tantucci C

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    pub_type: 杂志文章,meta分析


    authors: Franzosi MG,Maggioni AP,Tognoni G

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    authors: Hauck RW,Böhm M,Gengenbach S,Sunder-Plassmann L,Fruhmann G,Erdmann E

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    pub_type: 杂志文章


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