Single breath diffusing capacity for carbon monoxide in stable asthma.

Abstract:

BACKGROUND:Single breath diffusing capacity for carbon monoxide (Dco) is commonly used as a simple method of assessing overall pulmonary gas exchange properties. Studies of Dco in bronchial asthma have yielded conflicting results. OBJECTIVE:To study Dco and to determine the factors influencing Dco in patients with asthma. METHODS:Dco was prospectively measured in 80 consecutive never-smoker patients with uncomplicated stable asthma. The topographic distribution of lung perfusion was determined in 10 asthmatics and 10 controls, with a 133Xe radionuclide scan. RESULTS:The mean (SD) value of Dco was increased to 117 (17) percent of predicted values; individual values were either within or above normal limits; diffusion was also elevated at 116 (19) percent after correction for alveolar volume (transfer coefficient, D/VA). The Dco was not correlated with atopic status, duration of asthma, or results of spirometric tests; there was a weak negative correlation between D/VA and FEV1 or residual volume. There was a better perfusion of the upper zones of the lungs in asthmatics as compared with controls. Among the asthmatics, there was a strong positive correlation between Dco and the apex to base perfusion ratio (r = 0.975). CONCLUSIONS:Dco is normal or high among never smoker patients with uncomplicated asthma; elevated Dco may be attributed to a better perfusion of the apices of teh lungs; the latter could result from two mutually nonexclusive mechanisms: an increase in pulmonary arterial pressure and/or a more negative pleural pressure generated during inspiration as a consequence of bronchial narrowing. The unexpected finding of high Dco should raise the possibility of bronchial asthma in patients with otherwise undiagnosed conditions.

journal_name

Chest

journal_title

Chest

authors

Collard P,Njinou B,Nejadnik B,Keyeux A,Frans A

doi

10.1378/chest.105.5.1426

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

1426-9

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)38723-2

journal_volume

105

pub_type

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