A different balance in the sensitivity of D1 and D2 dopamine receptors accounts for differences in apomorphine-induced hypothermic effects in Swiss and C3H mice.

abstract：:The group III metabotropic glutamate (mGlu) receptors mGlu7 and mGlu8 are receiving increased attention as potential novel therapeutic targets for anxiety disorders. The effects mediated by these receptors appear to result from a complex interplay of facilitatory and inhibitory actions at different brain sites in the ...

journal_title：Neuropharmacology

authors： Dobi A,Sartori SB,Busti D,Van der Putten H,Singewald N,Shigemoto R,Ferraguti F

更新日期：2013-03-01 00:00:00

abstract：:The effects of the chronic administration of antidepressants on threshold electroconvulsive (ECS) seizures were evaluated in rats. Initially, tonic-clonic seizures were induced in 90% of the animals. Of those animals responding with tonic-clonic seizures, 42% had hindlimb extension (extensors); the remainder showed on...

journal_title：Neuropharmacology

authors： Peterson SL,Trzeciakowski JP,St Mary JS

更新日期：1985-10-01 00:00:00

abstract：:Symptomatic temporal lobe epilepsy typically develops in three phases: brain damage --> epileptogenesis --> spontaneous seizures (epilepsy). The challenge is to prevent epileptogenesis after injury. We hypothesized that alleviation of damage by caspase inhibitors will reduce epileptogenesis or at least have disease-mo...

journal_title：Neuropharmacology

authors： Narkilahti S,Nissinen J,Pitkänen A

更新日期：2003-06-01 00:00:00

abstract：:Intracerebroventricular (i.c.v.) administration of histamine in chloral anaesthetized rats exposed to an ambient temperature of 22 C elicited a rise in their colonic temperature associated with a shivering. This effect was shared by the H2 receptor agonists dimaprit and impromidine. Impromidine is, in this respect, a ...

journal_title：Neuropharmacology

authors： Colboc O,Protais P,Costentin J

更新日期：1982-01-01 00:00:00

abstract：:BU99006 is an irreversible I(2) ligand which selectively inactivates I(2) binding sites, making it an ideal tool with which to study I(2) site mechanism. We sought to determine the effects of BU99006 on I(2) binding in relation to monoamine oxidase (MAO), and the time course of these effects. In vitro, rat brain membr...

journal_title：Neuropharmacology

authors： Paterson LM,Tyacke RJ,Robinson ES,Nutt DJ,Hudson AL

更新日期：2007-02-01 00:00:00

abstract：:γ-Aminobutyric acid type A receptors that contain the δ subunit (δGABAA receptors) are expressed in multiple types of neurons throughout the central nervous system, where they generate a tonic conductance that shapes neuronal excitability and synaptic plasticity. These receptors regulate a variety of important behavio...

journal_title：Neuropharmacology

authors： Whissell PD,Lecker I,Wang DS,Yu J,Orser BA

更新日期：2015-01-01 00:00:00

abstract：:Ginsenoside Rg1 (Rg1) is a major bioactive ingredient in Panax ginseng that has low toxicity and has been shown to have neuroprotective effects. The objectives of the present study were to explore the potential of the application of Rg1 for the treatment of Parkinson's disease (PD) and to determine whether its neuropr...

journal_title：Neuropharmacology

authors： Zhou T,Zu G,Zhang X,Wang X,Li S,Gong X,Liang Z,Zhao J

更新日期：2016-02-01 00:00:00

abstract：:In this study we investigate the presence, modulation and biological function of P2 receptors and extracellular ATP in cultured cerebellar granule neurons. As we demonstrate by RT-PCR and western blotting, both P2X and P2Y receptor subtypes are expressed and furthermore regulated as a function of neuronal maturation. ...

journal_title：Neuropharmacology

authors： Amadio S,D'Ambrosi N,Cavaliere F,Murra B,Sancesario G,Bernardi G,Burnstock G,Volonté C

更新日期：2002-03-01 00:00:00

abstract：:Recently it has been reported that "I(f) channel blockers", which block the hyperpolarization-activated inward current (I(f)) in heart sino atrial node cells, also block the hyperpolarization-activated inward current (I(h)) in other tissues. Here we compared the effects of one of these agents, ZD7288 [4-(N-ethyl-N-phe...

journal_title：Neuropharmacology

authors： Satoh TO,Yamada M

更新日期：2000-04-27 00:00:00

abstract：:The bed nucleus of the stria terminalis (BNST) is a forebrain structure implicated in physiological and behavioral responses to emotional stress. However, the local neurochemical mechanisms mediating the BNST control of stress responses are not fully known. Here, we investigated the involvement of BNST cholinergic neu...

journal_title：Neuropharmacology

authors： Gouveia MK,Miguel TT,Busnardo C,Scopinho AA,Corrêa FM,Nunes-de-Souza RL,Crestani CC

更新日期：2016-02-01 00:00:00

abstract：:Microdialysis studies in animals have shown that addictive drugs preferentially increase extracellular dopamine (DA) in the n. accumbens (NAc). Brain imaging studies, while extending these finding to humans, have shown a correlation between psychostimulant-induced increase of extracellular DA in the striatum and self-...

journal_title：Neuropharmacology

authors： Di Chiara G,Bassareo V,Fenu S,De Luca MA,Spina L,Cadoni C,Acquas E,Carboni E,Valentini V,Lecca D

更新日期：2004-01-01 00:00:00

abstract：:Ligand-gated ion channels play a role in mediating fast synaptic transmission for communication between neurons. However, the structural basis for the functional coupling of the binding and pore domains, resulting in channel opening, remains a topic of intense investigation. Here, a series of α7 nicotinic receptor mut...

journal_title：Neuropharmacology

authors： Yan H,Pan N,Xue F,Zheng Y,Li C,Chang Y,Xu Z,Yang H,Zhang J

更新日期：2015-08-01 00:00:00

abstract：:The homotrimeric P2X3 subtype, one of the seven members of the ATP-gated P2X receptor family, plays a role in sensory neurotransmission, including nociception. To overcome the bias resulting from fast desensitization of the P2X3 receptor in dose-response analyses, a non-desensitizing P2X2-X3 receptor chimera has been ...

journal_title：Neuropharmacology

authors： Hausmann R,Bahrenberg G,Kuhlmann D,Schumacher M,Braam U,Bieler D,Schlusche I,Schmalzing G

更新日期：2014-04-01 00:00:00

abstract：:Brain preconditioning is a protective mechanism, which can be activated by sub-lethal stimulation of the NMDA receptors (NMDAR) and be used to achieve neuroprotection against stroke and neurodegenerative diseases models. Inhibitors of glycine transporters type 1 modulate glutamatergic neurotransmission through NMDAR, ...

journal_title：Neuropharmacology

authors： Pinto MC,Lima IV,da Costa FL,Rosa DV,Mendes-Goulart VA,Resende RR,Romano-Silva MA,de Oliveira AC,Gomez MV,Gomez RS

更新日期：2015-02-01 00:00:00

abstract：:Vesicular glutamate transporter 2 (VGLUT2)-which uptakes glutamate into presynaptic vesicles-is a fundamental component of the glutamate neurotransmitter system. Although several lines of evidence from genetically modified mice suggest a possible association of VGLUT2 with neuropathic pain, the specific role of VGLUT2...

journal_title：Neuropharmacology

authors： Zhang ZL,Yu G,Peng J,Wang HB,Li YL,Liang XN,Su RB,Gong ZH

更新日期：2020-03-01 00:00:00

abstract：:The effects of intracerebroventricular (i.c.v.) administration of NT on the activity of midbrain DA neurons were studied in rats using single unit recording techniques. NT (i.c.v., 50 micrograms) was found to have no significant effect on the spontaneous activity of DA cells. On the other hand, NT treatment significan...

journal_title：Neuropharmacology

authors： Shi WS,Bunney BS

更新日期：1990-11-01 00:00:00

abstract：:The excitatory amino acid antagonist, D-alpha-aminoadipate, was found to be a potent antagonist of responses to N-methyl-D-aspartate and L-aspartate, but less potent against L-glutamate responses of neurones in the rat caudal trigeminal nucleus. The responses to quisqualate and kainate were relatively unaffected by D-...

journal_title：Neuropharmacology

authors： Salt TE,Hill RG

更新日期：1982-05-01 00:00:00

abstract：:We examined the pharmacological properties of 3-methyl-aminothiophene dicarboxylic acid (3-MATIDA) by measuring second messenger responses in baby hamster kidney cells stably transfected with mGlu1a, mGlu2, mGlu4a or mGlu5a receptors and ionotropic glutamate receptor agonist-induced depolarizations in mouse cortical w...

journal_title：Neuropharmacology

authors： Moroni F,Attucci S,Cozzi A,Meli E,Picca R,Scheideler MA,Pellicciari R,Noe C,Sarichelou I,Pellegrini-Giampietro DE

更新日期：2002-05-01 00:00:00

abstract：:Carbenoxolone (CBX), the succinyl ester of glycyrrhetinic acid, is an inhibitor of gap junctional intercellular communication. Systemic administration of CBX was able to decrease the seizure severity score and to increase the latency time of seizure onset in genetically epilepsy prone rats (GEPRs). In particular, intr...

journal_title：Neuropharmacology

authors： Gareri P,Condorelli D,Belluardo N,Russo E,Loiacono A,Barresi V,Trovato-Salinaro A,Mirone MB,Ferreri Ibbadu G,De Sarro G

更新日期：2004-12-01 00:00:00

abstract：:The objective of this study was to compare nAChR-mediated neurotransmitter release from slices of rat striatum, frontal cortex and hippocampus following chronic (-)-nicotine (Nic) administration (tartrate salt, 2 mg/kg twice daily for 10 days). Binding studies were also conducted to measure changes in receptor density...

journal_title：Neuropharmacology

authors： Jacobs I,Anderson DJ,Surowy CS,Puttfarcken PS

更新日期：2002-10-01 00:00:00

abstract：:The effect of drugs which down-regulate the function of GABA at the level of the GABA/benzodiazepine receptor complex was studied on the conflict test in the rat. The GABA receptor antagonist, bicuculline, and the blockers of the GABA-receptor-coupled chloride channel, picrotoxin and pentylenetetrazol, produced a dose...

journal_title：Neuropharmacology

authors： Corda MG,Biggio G

更新日期：1986-05-01 00:00:00

abstract：:Slow excitatory postsynaptic currents (EPSCs) mediated by metabotropic glutamate receptors (mGlu receptors) have been reported in several neuronal subtypes, but their presence in hippocampal pyramidal neurons remains elusive. Here we find that in CA1 pyramidal neurons a slow EPSC is induced by repetitive stimulation w...

journal_title：Neuropharmacology

authors： Sheng N,Yang J,Silm K,Edwards RH,Nicoll RA

更新日期：2017-03-15 00:00:00

abstract：:The aim of this study was to determine the effects of sex, corticosterone and oestradiol-17 beta on the hypothermia and motor behavioural syndrome induced by the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the rat. The hypothermia, but not the behavioural syndrome induced by 8-OH-DPAT...

journal_title：Neuropharmacology

authors： Young AH,Dow RC,Goodwin GM,Fink G

更新日期：1993-07-01 00:00:00

abstract：:The importance of h5-HT1B receptor selectivity for 5-HT terminal autoreceptor activity was investigated with the selective h5-HT1B receptor ligands SB 219085, SB 220272, SB 224289 and SB 216641. The studies employed measurement of compound affinity and efficacy in vitro and the measurement of extracellular 5-HT in the...

journal_title：Neuropharmacology

authors： Roberts C,Price GW,Gaster L,Jones BJ,Middlemiss DN,Routledge C

更新日期：1997-04-01 00:00:00

abstract：:We evaluated the anticonvulsant efficacy of the antiepileptic drugs (AEDs) lamotrigine (LTG) and felbamate (FBM) in amygdala kindled rats that had been preselected with respect to their response to phenytoin. Anticonvulsant response was tested by determining the afterdischarge threshold (ADT), i.e., a sensitive measur...

journal_title：Neuropharmacology

authors： Ebert U,Reissmüller E,Löscher W

更新日期：2000-07-24 00:00:00

abstract：:Neurosteroids are synthesized in the brain and have been demonstrated to modulate various cerebral functions. Allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), a naturally occurring neurosteroid, and ganaxolone (3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a synthetic derivative, are two neurosteroids ac...

journal_title：Neuropharmacology

authors： Citraro R,Russo E,Di Paola ED,Ibbadu GF,Gratteri S,Marra R,De Sarro G

更新日期：2006-06-01 00:00:00

abstract：:Chlorpromazine, given either subcutaneously (0.375 mg/kg) or unilaterally into the preoptic/anterior hypothalamic area through a chronically implanted cannula (20 micrograms), was found to enhance the hypothermic response to delta-9-tetrahydrocannabinol (THC; 5 mg/kg i.p.) in unrestrained adult male MF1 mice, kept at ...

journal_title：Neuropharmacology

authors： Pertwee RG,Hedley D,McQueen AS,Gentleman SM

更新日期：1988-02-01 00:00:00

abstract：:The subtype-selectivity of racemic [(3)H]CP-101,606, a novel high-affinity NMDA receptor radioligand was determined using defined recombinant NMDA receptor subunits expressed in HEK 293 cells. [(3)H]CP-101,606 binds to adult rodent forebrain and NR1/NR2B receptors expressed in HEK 293 cells with K(D)=4.2 nM and 6.0 nM...

journal_title：Neuropharmacology

authors： Chazot PL,Lawrence S,Thompson CL

更新日期：2002-03-01 00:00:00

abstract：:We investigated the effect of 5-HT6 receptor subtype activation on glutamatergic transmission by means of whole-cell patch-clamp electrophysiological recordings from medium spiny neurons of the striatum and layer V pyramidal neurons of the prefrontal cortex. To this aim, we took advantage of a novel ligand, ST1936, sh...

journal_title：Neuropharmacology

authors： Tassone A,Madeo G,Schirinzi T,Vita D,Puglisi F,Ponterio G,Borsini F,Pisani A,Bonsi P

更新日期：2011-09-01 00:00:00

abstract：:Physical exercise has become a potentially beneficial therapy for reducing neurodegeneration symptoms in Alzheimer's disease. Previous studies have shown that cognitive deterioration, anxiety and the startle response observed in 7-month-old 3xTg-AD mice were ameliorated after 6 months of free access to a running wheel...

journal_title：Neuropharmacology

authors： Revilla S,Suñol C,García-Mesa Y,Giménez-Llort L,Sanfeliu C,Cristòfol R

更新日期：2014-06-01 00:00:00