Perioperative kinetics of heat shock protein 60 in serum during orthotopic liver transplantation.


INTRODUCTION:Heat shock proteins (HSP) play essential roles in the synthesis, transport, and folding of proteins. During ischemia/reperfusion (I/R) injury to orthotopic liver transplants (OLT), disassembly of oligomeric complexes and unfolding of proteins are likely to occur, producing a major burden on HSP to prevent and/or reverse these events. To date, all studies have evaluated HSP expression in tissues after an I/R injury. No data are available on HSP serum levels during I/R injury in liver graft recipients. PATIENTS AND METHODS:We evaluated the intraoperative and perioperative kinetics of HSP60 in the serum of 25 liver graft recipients. RESULTS:We observed a significant increase in serum levels of HSP60 at 4 hours compared with 30 minutes after reperfusion of the graft (P = .028). The perioperative HSP60 kinetics in serum neither correlated with the cold ischemia time nor the indocyanin green clearance. The type of preservation solution had no effect on serum HSP60 levels. CONCLUSION:This first study provides evidence for increased serum levels of HSP60 after reperfusion in OLT. The perioperative kinetics of HSP60 in serum may result from suppressed protein synthesis caused by a reduced energy charge of hepatocytes during early reperfusion, impaired transcription, and/or corticosteroid treatment. Further studies are needed to clarify the role of HSP60 under clinical conditions including immunosuppressive medications in human OLT.


Transplant Proc


Faybik P,Wachauer D,Hetz H,Bachleitner T,Steltzer H,Schett G,Krenn CG




Has Abstract


2004-06-01 00:00:00














  • Experience of the Reina Sofia Hospital in lung transplantation from donors older than forty years.

    abstract:INTRODUCTION:The shortage of suitable donors for lung transplantation (LT) has led to liberalization of criteria for donor selection. This study evaluated the outcomes of LT among a subset of patients receiving organs from standard donors older than 40 years of age. METHODS:We distributed patients who underwent LTs pe...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Moreno P,Alvarez A,Algar FJ,Cano JR,Espinosa D,Cerezo F,Baamonde C,Salvatierra A

    更新日期:2008-11-01 00:00:00

  • Among therapy modalities of end-stage renal disease, renal transplantation improves survival in patients with amyloidosis.

    abstract::The aim of this study was to investigate the results of renal transplantation in amyloidosis patients compared with those on hemodialysis. We compared a group of 25 patients with systemic amyloidosis and end-stage renal disease (ESRD) treated with renal transplantation with a control group of 30 patients with systemic...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ozdemir BH,Ozdemir FN,Sezer S,Sar A,Haberal M

    更新日期:2006-03-01 00:00:00

  • Clinical significance of prophylactic antibiotics in renal transplantation.

    abstract:INTRODUCTION:The use of new selective immunosuppressants as well as the emergence of new antimicrobial resistances raise the use of prophylactic antibiotics as a matter of controversy. The purpose of this study was to retrospectively analyze the clinical significance of prophylactic antibiotics in kidney transplantatio...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Choi SU,Lee JH,Oh CK,Shin GT,Kim H,Kim SJ,Kim SI

    更新日期:2013-05-01 00:00:00

  • Trough Level and Tacrolimus Variability of Early Converted Once-Daily Tacrolimus: 1-Year Follow-up Study.

    abstract:INTRODUCTION:Long-term transplant outcomes are considered a crucial point for kidney transplantation. Follow-up studies in patients receiving early conversion to once-daily tacrolimus (TAC-OD) are still limited. We aimed to investigate tacrolimus trough level (Cmin), intrapatient variability of tacrolimus dose-normaliz...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sukkha S,Suansanae T,Iamrahong P,Wiwattanathum P

    更新日期:2020-04-01 00:00:00

  • Effect of Institutional Case Volume on In-Hospital Mortality After Deceased Donor Liver Transplantation: A Nationwide Retrospective Cohort Study in Korea.

    abstract:BACKGROUND:There is still controversy as to whether the case volume affects clinical outcomes after liver transplantation. This nationwide retrospective cohort study aimed to investigate the relationship between institutional case volume and post-transplant outcomes after deceased donor liver transplantation. MATERIAL...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Yoo S,Jang EJ,Kim GH,Kim DH,Kwon SM,Lee H,Jung CW,Ryu HG

    更新日期:2018-12-01 00:00:00

  • Cytomegalovirus infections in cardiac transplant patients: an experience at a clinical hospital, university of Chile.

    abstract:BACKGROUND:Since cytomegalovirus (CMV) infects between 20% and 50% of heart transplant patients, we reviewed our experience in 7 cases of this infection. METHODS:A prospective analysis of CMV infection was performed in heart transplant patients who received cyclosporine, azathioprine, or mycophenolate mofetil, and pre...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sepulveda L,Llancaqueo M,Zamorano J,Bermudez C,Cortes C

    更新日期:2007-04-01 00:00:00

  • Heterogeneity of human pancreata in perspective of the isolation of the islets of langerhans.

    abstract::The success of human islet isolation is hampered by the varied and unpredictable outcomes of the islet isolation procedure. Pancreata which meet well-defined criteria are no guarantee for success. Interindividual variations may contribute to the differences in isolation outcomes. The present study examined several str...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Töns HA,Terpstra OT,Bouwman E

    更新日期:2008-03-01 00:00:00

  • Population of Cienfuegos (Cuba) and Their Knowledge About the Concept of Brain Death: Multivariate Analysis of the Associated Psychosocial Factors.

    abstract:INTRODUCTION:The favorable knowledge of the concept of brain death (BD) is a determinant for organ donation. OBJECTIVE:To analyze the level of knowledge of the concept of BD in the population of Cienfuegos (Cuba) and determine the factors that condition it. METHODS:Sample of Cubans residing in Cienfuegos (n = 636) st...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ríos A,López-Navas AI,Carrillo J,Sánchez Á,Martínez-Alarcón L,Ayala-García MA,Parrilla P,Ramírez P

    更新日期:2020-03-01 00:00:00

  • Biomarkers for the diagnosis of the stable kidney transplant and chronic transplant injury using the ProtoArray® technology.

    abstract::Transplant glomerulopathy (TG), a form of chronic renal transplant rejection, carries a poor prognosis. It must be differentiated from the entity defined by the Banff '05 classification, interstitial fibrosis/tubular atrophy (IF/TA). Sequential transplant biopsies have shown that these lesions are subclinical long bef...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Le Roux S,Devys A,Girard C,Harb J,Hourmant M

    更新日期:2010-11-01 00:00:00

  • Alpha-interferon with ribavirin in the treatment of hemodialysis patients with hepatitis C.

    abstract:INTRODUCTION:Hepatitis C Viral (HCV) infection is the leading cause of chronic liver disease in end-stage renal disease patients (ESRD). The impact of HCV on patient and graft survival posttransplantation is controversial. The most successful approach is to eliminate the virus while the patient is on dialysis prior to ...

    journal_title:Transplantation proceedings

    pub_type: 临床试验,杂志文章


    authors: Mousa DH,Abdalla AH,Al-Shoail G,Al-Sulaiman MH,Al-Hawas FA,Al-Khader AA

    更新日期:2004-07-01 00:00:00

  • Organ donation: key factors influencing families' decision-making.

    abstract:AIM:To clarify the decision-making and bereavement needs of family members who had organ donation discussed with them; to provide a rationale for further preparation of professionals involved in this sensitive work. METHODS:This work used a 3-year longitudinal design. A sample of 49 family members who had donation dis...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sque M,Long T,Payne S

    更新日期:2005-03-01 00:00:00

  • The contraceptive vaginal ring in women with renal and liver transplantation: analysis of preliminary results.

    abstract:INTRODUCTION:Vaginal administration seems to be the best route to achieve steady and precise doses of contraceptive hormones, resulting in stable serum concentrations and low exposure. The aim of this study was to evaluate the contraceptive efficacy, cycle control, tolerability and acceptability of a contraceptive vagi...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Paternoster DM,Riboni F,Bertolino M,Garofalo G,Lazzarich E,Surico N,Stratta P

    更新日期:2010-05-01 00:00:00

  • Evolution of Organ Transplantation in Poland 1966 to 2014: Dates and Numbers.

    abstract:BACKGROUND:Several events inspired us to collect data on organ transplantation in Poland (2016: the 50th anniversary of the first transplantation and the 20th anniversary of Polish Transplant Coordinating Center Poltransplant). The paper aims at presenting comprehensive data on all organ transplants, beginning with the...

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    authors: Czerwiński J,Czapiewski W,Danielewska E,Milaniak I,Milecka A,Patrzałek D,Sekta S,Saucha W,Danek T,Zając K,Ostrowski K,Malanowski P

    更新日期:2016-06-01 00:00:00

  • Visfatin, a new adipocytokine, is predominantly related to inflammation/endothelial damage in kidney allograft recipients.

    abstract::Visfatin, a ubiquitous adipokine, was first described in 2005. It was found to be selectively up-regulated in the adipose tissue and to have insulin-mimetic effects. It has been reported that visfatin is associated with endothelial damage in chronic kidney disease. We investigated plasma visfatin levels (using commerc...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Malyszko J,Malyszko JS,Mysliwiec M

    更新日期:2009-01-01 00:00:00

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    abstract::One-third of the liver transplantations are performed because of hepatitis C cirrhosis all over the world and also in Hungary. The recurrence rate is practically 100%, influencing graft and patient survivals; within 5 years cirrhosis develops again in 20% to 30% of cases. The therapy is pegylated interferon α-2a and α...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Gerlei Z,Sárváry E,Lengyel G,Görög D,Fehérvári I,Nemes B,Kóbori L,Langer RM

    更新日期:2012-09-01 00:00:00

  • Immunosuppressive agents and metabolic factors of cardiovascular risk in renal transplant recipients.

    abstract::Cardiovascular disease (CVD) accounts for 35% to 50% of deaths among renal transplant recipients. Beside the atherogenic risk factors related to hemodialysis, renal function, and use of immunosuppressive agents, other relevant risk factors for CVD include acute rejection episodes, microalbuminuria (muAlb), diabetes, a...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sessa A,Esposito A,Giliberti A,Iavicoli G,Costa C,Bergallo M,Lettieri E,Rossano R,Capuano M

    更新日期:2009-05-01 00:00:00

  • Granzyme B and perforin as predictive markers for acute rejection in human intestinal transplantation.

    abstract::In human heart and kidney transplantations, granzyme B (GrB) and perforin have both been shown to be predictive markers for acute cellular rejection (ACR). We investigated the tissue expression and possible relationship of GrB and perforin to the clinical outcome, histopathology, and function of intestinal transplants...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: D'Errico A,Corti B,Pinna AD,Altimari A,Gruppioni E,Gabusi E,Fiorentino M,Bagni A,Grigioni WF

    更新日期:2003-12-01 00:00:00

  • Assessment of the degree of satisfaction among living kidney donors.

    abstract:BACKGROUND:Organ donation during life is an act of great altruism, with unique family, social, economic, and psychological impacts. The group of anesthesiologists involved in this program sought to assess the degree of satisfaction among kidney donors between 2007 and 2008 and, in particular, with the anesthetic approa...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Oliveira B,Mascarenhas C,Cardoso G,Sá J,Casal M

    更新日期:2011-01-01 00:00:00

  • Does multiorgan versus kidney-only cadaveric organ procurement affect graft outcomes?

    abstract:INTRODUCTION:The majority of kidney grafts in most European countries still come from deceased donors who provide other organs. We analyzed whether multiorgan procurement portends a worse functional outcome compared with kidney-only harvesting. METHODS:We performed a retrospective analysis of 1043 consecutive brain-de...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Castelo D,Campos L,Moreira P,Furriel F,Parada B,Nunes P,Figueiredo A,Mota A

    更新日期:2013-04-01 00:00:00

  • Asian Indian donor marrow registry: All India Institute of Medical Sciences experience.

    abstract::A major limitation in hematopoietic stem cell transplantation (HSCT) is the availability of a genetically matched donor, particularly with respect to the human leukocyte antigens (HLA)-linked immune response genes located on chromosome 6 in humans. During the last 5 years, a total of 688 patients requiring HSCT underw...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kanga U,Panigrahi A,Kumar S,Mehra NK

    更新日期:2007-04-01 00:00:00

  • Brain Death: Is It a Misunderstood Concept Among Nursing Students in the South of Poland?

    abstract:BACKGROUND:The objective of the present study was to analyze the knowledge and acceptance of the brain death (BD) concept among nursing students. METHODS:The study was undertaken in the academic year of 2011 to 2012 in nursing students from the University of the South of Poland. The sample was carried out in compulsor...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Mikla M,Ríos A,López-Navas A,Kasper M,Brzostek T,Martínez-Alarcón L,Ramis G,Ramírez P,López-Montesinos MJ

    更新日期:2015-11-01 00:00:00

  • Basiliximab (Simulect) reduces acute rejection among sensitized kidney allograft recipients.

    abstract:AIMS:Our goal was to evaluate the efficacy and safety of basiliximab (Simulect) as immunosuppressive induction therapy for the prevention of acute allograft rejection among sensitized kidney recipients. METHODS:Fifty-six adult recipients receiving cadaveric kidney transplant with panel reactive antibody class I rangin...

    journal_title:Transplantation proceedings

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tan J,Yang S,Wu W

    更新日期:2005-03-01 00:00:00

  • Factors Affecting Recurrence and Survival After Liver Transplantation for Hepatocellular Carcinoma.

    abstract:INTRODUCTION:Liver transplantation (LT) remains the best treatment option for hepatocellular carcinoma (HCC). Patient selection is crucial and debated ever since the emerging of the Milan criteria in 1996. As live-donor LT is being more routinely performed worldwide, numerous new and/or expansions of the original crite...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Yilmaz C,Karaca CA,Iakobadze Z,Farajov R,Kilic K,Doganay L,Kilic M

    更新日期:2018-12-01 00:00:00

  • Switch to everolimus for sirolimus-induced pneumonitis in a liver transplant recipient--not all proliferation signal inhibitors are the same: a case report.

    abstract::We report a 62-year-old female liver transplant patient who presented with sirolimus (SIR)-related pneumonitis (SIP) treated with a switch to everolimus (EVER). At 13-month follow-up, the patient is on EVER monotherapy with no recurrence of SIP. Despite common mechanisms of action, the safety profile of EVER is differ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: De Simone P,Petruccelli S,Precisi A,Carrai P,Doria R,Menichetti F,Filipponi F

    更新日期:2007-12-01 00:00:00

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    abstract::The development of early acute renal dysfunction (eARD) occurring in the first week after orthotopic liver transplantation (OLT) is mainly influenced by more severe degrees of pre-OLT hepatic insufficiency and liver graft dysfunction. The aim of our study was to evaluate the incidence of eARD post-OLT as well as its a...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Umbro I,Rossi M,Tinti F,Fiacco F,Piselli P,Ianni S,Ginanni Corradini S,Poli L,Berloco PB,Mitterhofer AP

    更新日期:2012-09-01 00:00:00

  • Bloodstream cells phenotypically identical to human mesenchymal bone marrow stem cells circulate in large amounts under the influence of acute large skin damage: new evidence for their use in regenerative medicine.

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Mansilla E,Marín GH,Drago H,Sturla F,Salas E,Gardiner C,Bossi S,Lamonega R,Guzmán A,Nuñez A,Gil MA,Piccinelli G,Ibar R,Soratti C

    更新日期:2006-04-01 00:00:00

  • Respiratory distress syndrome caused by influenza H1N1 in a patient with a simultaneous pancreas-kidney transplantation.

    abstract::Adult respiratory distress syndrome is a severe respiratory failure due to noncardiogenic pulmonary edema with high mortality rates (50-70%). The most common etiology of respiratory distress is sepsis, but it may also be caused by several of the immunosuppressants prescribed in transplantation. In the last year, influ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Fraile P,Muñoz-Bellvis L,Cacharro LM,García-Cosmes P,Tabernero JM

    更新日期:2013-11-01 00:00:00

  • Prevalence and manifestations of tuberculosis in renal transplant recipients: a single-center experience in Thailand.

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ruangkanchanasetr P,Natejumnong C,Kitpanich S,Chaiprasert A,Luesutthiviboon L,Supaporn T

    更新日期:2008-09-01 00:00:00

  • Lack of Relationship Between Renal Function and Genetic Variants of CYP3A4, CYP3A5, MDR1, MRP2, UGT1A9, UGT1A8, and UGT2B7 in Patients After Liver Transplantation in a 2-Year Follow-up.

    abstract:BACKGROUND:The prolonged survival time after liver transplantation (LTX) creates the possibility of the occurrence and development of complications in the late post-transplantation period. Deterioration of renal function is 1 of these complications. The nephrotoxicity of calcineurin inhibitors (CNIs) and their metaboli...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Hryniewiecka E,Zegarska J,Zochowska D,Pączek L

    更新日期:2020-10-01 00:00:00

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Zhang SJ,Chen S

    更新日期:2004-09-01 00:00:00