Platinum and palladium complexes containing ethylenediamine derivatives as carrier ligands and their antitumor activity.


:We prepared new antitumor active platinum complexes containing N,N'-bis(2-chloroethyl)ethylenediamine (ClEn) as an alkylating carrier ligand in order to obtain increased antitumor effects. Some of the platinum complexes synthesized showed enhanced antitumor activity. However, palladium(II) complexes containing ClEn were inactive against L1210 and P388.


Lee K,Tashiro T,Noji M




Has Abstract


1994-03-01 00:00:00












  • Preparation of N'-[2-(5,6-dimethylbenzothiazolyl)]-N-furfuryloxamide with plant growth regulatory activity.

    abstract::The reaction of the N-furfuryloxamic acid sodium salt (12) with 1,1'-oxalyldiimidazole (ODI) yielded the imidazolide (13) as an intermediate, and this directly reacted with 2-aminothiazole derivatives (14) or 2-aminobenzothiazole derivatives (15) under essentially neutral conditions to afford the N'-12-(substituted th...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kitagawa T,Tsutsui C

    更新日期:2000-09-01 00:00:00

  • Cardenolides from Antiaris toxicaria as potent selective Nur77 modulators.

    abstract::Toxicarioside D (1), a new cardenolide, along with 10 other known ones, was isolated from the stem of Antiaris toxicaria LESCH. by bioassay-guided fractionation. Their structures were determined on the basis of spectroscopic analysis. All the reported compounds effectively inhibited the growth of various cancer cell l...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Jiang MM,Dai Y,Gao H,Zhang X,Wang GH,He JY,Hu QY,Zeng JZ,Zhang XK,Yao XS

    更新日期:2008-07-01 00:00:00

  • New 5-HT3 (serotonin-3) receptor antagonists. IV. Synthesis and structure-activity relationships of azabicycloalkaneacetamide derivatives.

    abstract::The synthesis and structure-activity relationships of a series of new azabicycloalkanes as 5-HT3 (serotonin-3) receptor antagonists are described. Our study on the azabicycloalkaneacetamide derivatives showed that 2,3-dihydroindole as the aromatic ring moiety afforded potent 5-HT3 receptor antagonist activity, as judg...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kato M,Ito K,Nishino S,Yamakuni H,Takasugi H

    更新日期:1995-08-01 00:00:00

  • The complete amino acid sequence of an abortifacient protein, karasurin.

    abstract::The complete amino acid sequence of a new abortifacient protein, karasurin, was determined. Karasurin, which was isolated from fresh root tubers of Trichosanthes kirilowii Maximowicz var, japonicum Kitamura (Cucurbitaceae), was a highly basic protein with pI 10.1 and molecular weight of 28,000. Intact karasurin was cl...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Toyokawa S,Takeda T,Kato Y,Wakabayashi K,Ogihara Y

    更新日期:1991-05-01 00:00:00

  • Novel cycloundecapeptides related to gramicidin S with both high antibiotic activity and low hemolytic activity.

    abstract::To find candidates with high antimicrobial and low hemolytic activities, many gramicidin S (GS) analogs of various ring sizes have been designed and synthesized. However, syntheses of antimicrobially active analogues of GS having a disordered symmetry structure from C(2) have almost never been reported, because the st...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Tamaki M,Takanashi K,Harada T,Fujinuma K,Shindo M,Kimura M,Uchida Y

    更新日期:2011-01-01 00:00:00

  • An IC-MS/MS Method for the Determination of 1-Hydroxyethylidene-1,1-diphosphonic Acid on Uncooked Foods Treated with Peracetic Acid-Based Sanitizers.

    abstract::A rapid, sensitive, and specific analytical method for the determination of 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP) on uncooked foods after treatment with a peracetic acid-based sanitizer (PAS) was developed. The method involves simple sample preparation steps and analysis using ion chromatography (IC) couple...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Suzuki I,Kubota H,Ohtsuki T,Tatebe C,Tada A,Yano T,Akiyama H,Sato K

    更新日期:2016-01-01 00:00:00

  • Deoxymanoalides from the nudibranch Chromodoris willani.

    abstract::Two sesterterpenes, deoxymanoalide (1) and deoxysecomanoalide (2), were isolated from the nudibranch Chromodoris willani collected in Okinawa and their structures determined on the basis of spectroscopic data and chemical conversions. The mollusk feeds on a sponge containing manoalide (3) and secomanoalide (4) and is ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Uddin MH,Otsuka M,Muroi T,Ono A,Hanif N,Matsuda S,Higa T,Tanaka J

    更新日期:2009-08-01 00:00:00

  • Metabolic fate of [14C]triglyceride-entrapped lactosylceramide-bearing liposomes after intravenous injection into mouse.

    abstract::We investigated the distribution and fate of liposomes after their intravenous injection into a mouse. Liposomes were composed of dimyristoylphosphatidylcholine, cholesterol and dicetylphosphate (7:2:1, molar ratio) with or without lactosylceramide. They were characterized as small unilamellar vesicles, approximately ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Yoshioka S,Banno Y,Okano Y,Ohki K,Mizukami Y

    更新日期:1992-04-01 00:00:00

  • The antimalarial agent halofantrine perturbs phosphatidylcholine and phosphatidylethanolamine bilayers: a differential scanning calorimetric study.

    abstract::The interaction of halofantrine with phosphatidylcholine and phosphatidylethanolamine bilayers has been investigated by differential scanning calorimetry. Halofantrine caused a broadening of the gel to liquid crystalline phase transition endotherm of the phosphatidylcholines. A decrease in the transition temperature T...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Lim LY,Go ML

    更新日期:1999-06-01 00:00:00

  • Synthesis and antinociceptive activity of orally active opioid peptides: improvement of oral bioavailability by esterification.

    abstract::To improve the oral bioavailability of a dermorphin tetrapeptide analog, N(alpha)-1-iminoethyl-Tyr-D-MetO-Phe-MebetaAla-OH (III), which has a potent analgesic activity after oral administration, various derivatives were synthesized to increase lipophilicity by esterification of the C-terminal carboxyl group and/or acy...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ogawa T,Araki M,Miyamae T,Okayama T,Hagiwara M,Sakurada S,Morikawa T

    更新日期:2003-07-01 00:00:00

  • Preparation of new nitrogen-bridged heterocycles. 49. A new access to thieno[3,4-b]indolizine derivatives.

    abstract::The title compounds, together with 3-vinylindolizine-1-carbonitriles (4-56%), were prepared in 1-18% yields from the S-alkylation of pyridinium 1-[3-ethoxycarbonyl-1-[cyanomethylthio(thiocarbonyl)]]all ylides with alkyl halides, followed by treatment of the resulting pyridinium salts with a base and then a dehydrogena...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kakehi A,Ito S,Hirata K,Zuo P

    更新日期:2000-06-01 00:00:00

  • Inner-hydrogen tautomerism in some 5,15-unsymmetrically disubstituted and beta-unsubstituted porphyrins.

    abstract::5,15-Unsymmetrically disubstituted and beta-unsubstituted porphyrins such as 5-R, 15-(3,5-dimethoxyphenyl) porphyrins [where R=2-benzyloxy-1-naphthyl (1), 2-(2-naphthylmethoxy)-1-naphthyl (2), anthryl (3), or 2,4,6-triphenylphenyl (4)] and 5-(2-benzyloxy-1-naphthyl), 10,15,20-tri(3,5-dimethoxyphenyl) porphyrin (1') we...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Tohara A,Sato M

    更新日期:2008-07-01 00:00:00

  • Synthesis of 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactic acid, an important intermediate of rosmarinic acid biosynthesis.

    abstract::A simple method to synthesize (+/-)-2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactic acid (1), a key intermediate in rosmarinic acid biosynthesis in higher plant cells, was established by condensation of protected 4-coumaric acid and (+/-)-3-(4-hydroxyphenyl)lactic acid followed by deprotection. A stable supply of 1 thus a...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Matsuno M,Nagatsu A,Ogihara Y,Mizukami H

    更新日期:2001-12-01 00:00:00

  • Cathodic adsorptive stripping square-wave voltammetry of the anti-inflammatory drug meloxicam.

    abstract::The adsorptive behavior of the anti-inflammatory drug meloxicam was studied by cyclic, differentia-pulse and square-wave voltammetry on a hanging mercury drop electrode (HMDE). The drug was accumulated at HMDE and a well-defined stripping peak current was obtained at -1.42 V vs. Ag/AgCl (saturated KCl) electrode in ac...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Radi AE,Ghoneim M,Beltagi A

    更新日期:2001-10-01 00:00:00

  • Synthesis and antitumor activity of 20(S)-camptothecin derivatives: A-ring modified and 7,10-disubstituted camptothecins.

    abstract::20(S)-Camptothecin derivatives having nitro, amino, chloro, bromo, hydroxyl and methoxyl groups in the A-ring were synthesized. B-Ring hydrogenated camptothecin (2a) was converted into 10-hydroxycamptothecin (6e) by treatment with lead tetraacetate in trifluoroacetic acid. 10-Substituted derivatives (6) were obtained ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Sawada S,Matsuoka S,Nokata K,Nagata H,Furuta T,Yokokura T,Miyasaka T

    更新日期:1991-12-01 00:00:00

  • Studies on anti-inflammatory agents. V. Synthesis and pharmacological properties of 3-(difluoromethyl)-1-(4-methoxyphenyl)-5- [4-(methylsulfinyl)phenyl]pyrazole and related compounds.

    abstract::A series of novel 1,5-diphenylpyrazole derivatives bearing hydrophilic substituents was prepared. The anti-inflammatory and analgesic activities of these compounds were evaluated by using the adjuvant arthritis and Randall-Selitto assays in rats, and the structure-activity relationships were studied. The optimal compo...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Tsuji K,Konishi N,Spears GW,Ogino T,Nakamura K,Tojo T,Ochi T,Shimojo F,Senoh H,Matsuo M

    更新日期:1997-09-01 00:00:00

  • Formal (3+3) cycloaddition of silyl enol ethers catalyzed by trifric imide: domino Michael addition-claisen condensation accompanied with isomerization of silyl enol ethers.

    abstract::We describe here a Tf₂NH-catalyzed formal (3+3) cycloaddition of silyl enol ethers with acrylates as a new domino reaction. In the domino sequence, the catalyst activates Michael addition, deprotonation of the resulting silyloxonium cation and intramolecular Claisen condensation. It was found that reaction modes signi...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Azuma T,Takemoto Y,Takasu K

    更新日期:2011-01-01 00:00:00

  • Adsorption properties of As(III) and Cr(VI) in water environment by calcined gibbsite.

    abstract::The adsorption properties of As(III) and Cr(VI) by gibbsite (GB) calcined at 200 to 1150 degrees C was investigated on basis of their specific surface area, number of hydroxyl groups, surface pH and adsorption isotherms. The amount of As(III) and Cr(VI) adsorbed on the calcined GB at 300 or 400 degrees C was the highe...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ogata F,Kawasaki N,Kabayama M,Kakehi K

    更新日期:2009-02-01 00:00:00

  • alpha,alpha-gem-Difluorination of alpha-(alkylthio)acetophenone derivatives with N-fluoropyridinium salts.

    abstract::The alpha,alpha-gem-difluorination of 2',4'-difluoro-alpha-(methylthio)acetophenone (1a) with N-fluoropyridinium salts gave 2',4',alpha,alpha-tetrafluoro-alpha-(methylthio)acetophenone (3a). This reaction was accelerated by the addition of zinc chloride, zinc bromide or anhydrous iron(III) chloride, and higher yields ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Takeda S,Kaneko Y,Eto H,Tokizawa M,Sato S,Yoshida K,Namiki S,Ogawa M

    更新日期:2000-07-01 00:00:00

  • Synthesis of new immunosuppressive myriocin analogs, 2-epi-myriocin, 14-deoxomyriocin, Z-14-deoxomyriocin, and nor-deoxomyriocins: their structure-activity relationships.

    abstract::Eight new myriocin analogs, 2-epi-myriocin, Z-14-deoxomyriocin, and nor-deoxomyriocins, and a known myriocin derivative, 14-deoxomyriocin, were synthesized from 2-deoxy-D-glucose via common intermediates in previous myriocin and Z-myriocin syntheses. The immunosuppressive activities of new myriocin analogs and Z-myrio...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Yoshikawa M,Yokokawa Y,Okuno Y,Yagi N,Murakami N

    更新日期:1994-12-01 00:00:00

  • Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil.

    abstract::From the water extract of Brazilian Tabebuia avellanedae, two new iridoids (1, 2) and a new phenylethanoid glycoside (3) have been isolated together with twelve known compounds (4-15). Their structures were determined based on the spectroscopic data. The isolated compounds inhibited nitric oxide (NO) production in lip...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Awale S,Kawakami T,Tezuka Y,Ueda JY,Tanaka K,Kadota S

    更新日期:2005-06-01 00:00:00

  • Synthetic studies of vitamin D analogues. XIV. Synthesis and calcium regulating activity of vitamin D3 analogues bearing a hydroxyalkoxy group at the 2 beta-position.

    abstract::Four vitamin D3 analogues (7a, 7b, 7c and 7d) bearing a hydroxyalkoxy group at the 2 beta-position were synthesized from the alpha-epoxide (5). The C-3 analogue (7b) showed the highest potency for elevating plasma calcium levels in rats. Furthermore, the 25-hydroxylated C-3 analogue (ED-71) (3), prepared from the 25-h...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Miyamoto K,Murayama E,Ochi K,Watanabe H,Kubodera N

    更新日期:1993-06-01 00:00:00

  • Optically active cyclohexene derivative as a new antisepsis agent: an efficient synthesis of ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242).

    abstract::Two new synthetic methods were established for the efficient synthesis of optically active cyclohexene antisepsis agent, ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate [(R)-1: TAK-242)]. The first method involved recrystallization from methanol of the diastereomeric mixture (6RS,1'R)-7...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Yamada M,Ichikawa T,Yamano T,Kikumoto F,Nishikimi Y,Tamura N,Kitazaki T

    更新日期:2006-01-01 00:00:00

  • A novel analytical method for pharmaceutical polymorphs by terahertz spectroscopy and the optimization of crystal form at the discovery stage.

    abstract::A novel analytical method for the determination of pharmaceutical polymorphs was developed using terahertz spectroscopy. It was found out that each polymorph of a substance showed a specific terahertz absorption spectrum. In particular, analysis of the second derivative spectrum was enormously beneficial in the discri...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Ikeda Y,Ishihara Y,Moriwaki T,Kato E,Terada K

    更新日期:2010-01-01 00:00:00

  • Control of Drug Diffusion Behavior of Xanthan and Locust Bean Gum Gel by Agar Gel.

    abstract::Oral gel formulations are known as easy to administer drug products for patients who have problems taking drugs including those with conditions such as dysphagia. In addition, there are numerous commercially available oral gel products, most of which are immediate-release formulation that release their pharmaceutical ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Hishikawa Y,Kakino Y,Tsukamoto H,Tahara K,Onodera R,Takeuchi H

    更新日期:2016-01-01 00:00:00

  • Production of sesquiterpene-type phytoalexins by hairy roots of Hyoscyamus albus co-treated with cupper sulfate and methyl jasmonate.

    abstract::The production of sesquiterpene-type phytoalexins with a vetispyradiene skeleton by Hyoscyamus albus hairy roots induced by methyl jasmonate (MeJA) was reported in a previous paper. The production pattern on co-treatment with cupper sulfate and MeJA (CuSO(4)-MeJA) showed a TLC profile differing from that on treatment ...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Kawauchi M,Arima T,Shirota O,Sekita S,Nakane T,Takase Y,Kuroyanagi M

    更新日期:2010-07-01 00:00:00

  • Lignans from Santalum album and their cytotoxic activities.

    abstract::A new neolignan, (7R,8R)-5-O-demethylbilagrewin (1), together with four known lignans (2-5), were isolated from the heartwood of Santalum album (Santalaceae). The structure of 1 was determined by analysis of extensive spectroscopic data. The isolated compounds and derivatives were evaluated for their cytotoxic activit...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Matsuo Y,Mimaki Y

    更新日期:2010-04-01 00:00:00

  • Application of Ulex europaeus agglutinin I-modified liposomes for oral vaccine: Ex Vivo bioadhesion and in Vivo immunity.

    abstract::The conjugation of Ulex europaeus agglutinin I (UEAI) onto surface of liposomes has been demonstrated to effectively improve the intestinal absorption of antigen, subsequently induced strong mucosal and systemic immune responses. In this context, we prepared bovine serum albumin (BSA)-encapsulating UEAI-modified lipos...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Li K,Zhao X,Xu S,Pang D,Yang C,Chen D

    更新日期:2011-01-01 00:00:00

  • Light irradiation is a factor in the bactericidal activity of silver-loaded zeolite.

    abstract::Silver loaded zeolite (Ag-Z) was previously found to have effective bactericidal activity against Escherichia coli. To understand the mechanisms of bactericidal activity of Ag-Z, role of light irradiation was focused and investigated in this study. In this study, we focused on light irradiation. Antibacterial assay an...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Inoue Y,Kogure M,Matsumoto K,Hamashima H,Tsukada M,Endo K,Tanaka T

    更新日期:2008-05-01 00:00:00

  • An efficient synthesis of 5-bromo-2-methoxy-6-methylaminopyridine-3carboxylic acid.

    abstract::An efficient synthesis of 5-bromo-2-methoxy-6-methylaminopyridine-3-carboxylic acid (1), a carboxylic acid moiety of a potent dopamine D2 and D3 and serotonin-3 (5-HT3) receptors antagonist, (R)-5-bromo-N-(1-ethyl-4-methylhexahydro-1 ,4-diazepin-6-yl)-2-methoxy-6-methylaminopyridine-3-carboxamide, is described. Reacti...

    journal_title:Chemical & pharmaceutical bulletin

    pub_type: 杂志文章


    authors: Hirokawa Y,Horikawa T,Kato S

    更新日期:2000-12-01 00:00:00