Abstract:
:Four new cembrane diterpenes (1-4) and fifteen known cembranoids (5-19) were isolated from an Okinawan soft coral Lobophytum crassum. The structures of these four new cembranoids were determined on the basis of spectroscopic evidence. In particular, the absolute stereochemistry of 1, 2, 5 and 6 were elucidated by the application of the modified Mosher's method and circular dichroism (CD) spectral data. The inhibitory effects of some isolates were evaluated on nitric oxide (NO) production against a murine macrophage-like cell line (Raw 264.7). Cembranoids consisting of alpha-methylene-gamma-lactone, exhibited the significant effect on NO production.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Wanzola M,Furuta T,Kohno Y,Fukumitsu S,Yasukochi S,Watari K,Tanaka C,Higuchi R,Miyamoto Tdoi
10.1248/cpb.58.1203subject
Has Abstractpub_date
2010-09-01 00:00:00pages
1203-9issue
9eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/58.1203journal_volume
58pub_type
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