Four new neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities.

Abstract:

:Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines C-F (1-4), were isolated from the whole plants of Scutellaria barbata D. DON. Their structures were elucidated by spectral analyses (UV, IR, FAB-MS, 1D-NMR and 2D-NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC(50) values in the range 3.9-7.8 muM.

authors

Dai SJ,Chen M,Liu K,Jiang YT,Shen L

doi

10.1248/cpb.54.869

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

869-72

issue

6

eissn

0009-2363

issn

1347-5223

pii

JST.JSTAGE/cpb/54.869

journal_volume

54

pub_type

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