Abstract:
:Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines C-F (1-4), were isolated from the whole plants of Scutellaria barbata D. DON. Their structures were elucidated by spectral analyses (UV, IR, FAB-MS, 1D-NMR and 2D-NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC(50) values in the range 3.9-7.8 muM.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Dai SJ,Chen M,Liu K,Jiang YT,Shen Ldoi
10.1248/cpb.54.869subject
Has Abstractpub_date
2006-06-01 00:00:00pages
869-72issue
6eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/54.869journal_volume
54pub_type
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