Hypercalcemia of malignancy: a review of advances in pathophysiology.

Abstract:

PURPOSE/OBJECTIVES:To review normal calcium homeostasis, recent advances in understanding the pathologic mechanisms responsible for precipitating hypercalcemia of malignancy, the role of the kidneys in potentiating hypercalcemia, and the principles of antihypercalcemic treatment. DATA SOURCES:Journal articles, edited reference works, and selected texts. DATA SYNTHESIS:A complex set of changes in calcium processing in the intestine, kidney, and bone, mediated by humoral factors released from or induced by malignant cells, is responsible for development of humoral hypercalcemia of malignancy (HHM). CONCLUSIONS:A minor cause of cancer-induced hypercalcemia is bone destruction resulting from direct tumor invasion. Synergistic interactions between humoral factors stimulated by the presence of malignant cells enhance bone resorption of calcium and impair renal excretion of calcium ions resulting in HHM. Essential facets of antihypercalcemic treatment include controlling the precipitating malignancy, reversing dehydration, and inhibiting bone resorption. IMPLICATIONS FOR NURSING PRACTICE:The signs and symptoms of increasing serum calcium are difficult to distinguish from disease-related or cytotoxic treatment-related side effects. Oncology nurses must have an understanding of which malignancies pose increased risk and how pathophysiologic mechanisms precipitate or contribute to hypercalcemia of malignancy. Knowledge of the rationales for the various treatment modalities will assist nurses in implementing antihypercalcemic treatments, evaluating treatment effectiveness and side effects, instituting pain management programs, and providing comfort measures and emotional support.

journal_name

Oncol Nurs Forum

journal_title

Oncology nursing forum

authors

Kaplan M

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

1039-46; quiz 1047-8

issue

6

eissn

0190-535X

issn

1538-0688

journal_volume

21

pub_type

杂志文章,评审
  • Abnormal Pap screening among Mexican-American women: impediments to receiving and reporting follow-up care.

    abstract:PURPOSE/OBJECTIVES:To understand impediments to receiving and reporting timely follow-up care for abnormal Pap tests among Hispanic women. DESIGN:Descriptive, qualitative. SETTING:A federally funded cancer screening clinic in urban South Texas. SAMPLE:11 Mexican/Mexican-American women over 40 years old who appear in...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:

    authors: Hunt LM,de Voogd KB,Akana LL,Browner CH

    更新日期:1998-11-01 00:00:00

  • Genetic Influence on Chemotherapy-Induced Nausea and Vomiting: A Narrative Review.

    abstract::Chemotherapy-induced nausea and vomiting (CINV) is a phenomenon common to patients being treated for a solid or hematologic malignancy. This adverse effect to cancer treatment persists in about half of all patients receiving highly emetogenic treatment, despite prophylaxis with serotonin (5-hydroxytryptamine-3 [5-HT3]...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章,评审

    doi:10.1188/16.ONF.389-393

    authors: Kiernan J

    更新日期:2016-05-01 00:00:00

  • eHealth Literacy and Partner Involvement in Treatment Decision Making for Men With Newly Diagnosed Localized Prostate Cancer

    abstract:PURPOSE/OBJECTIVES:To examine how the eHealth literacy of partners of patients with newly diagnosed prostate cancer affects their involvement in decision making, and to identify the factors that influence their eHealth literacy.
. DESIGN:Cross-sectional exploratory study.
. SETTING:North Carolina.
. SAMPLE:142 partn...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:10.1011/17.ONF.225-233

    authors: Song L,Tatum K,Greene G,Chen RC

    更新日期:2017-03-01 00:00:00

  • Outcome measures to evaluate the effectiveness of pain management in older adults with cancer.

    abstract:PURPOSE/OBJECTIVES:To identify the most appropriate outcome measures to determine the effectiveness of pain management plans in older adults with cancer. DATA SOURCES:PubMed literature searches, medical and nursing textbooks, and clinical experience. DATA SYNTHESIS:Unrelieved chronic pain can have a significant impac...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:10.1188/10.ONF.S1.27-32

    authors: Miaskowski C

    更新日期:2010-09-01 00:00:00

  • Symptom clusters in Chinese patients with primary liver cancer.

    abstract:PURPOSE/OBJECTIVES:To derive symptom clusters and their clinical meanings in Chinese patients with primary liver cancer (PLC), to examine the factors related to the identified symptom clusters, and to validate the impact of the identified symptom clusters on patients' quality of life (QOL). DESIGN:Cross-sectional. SE...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:10.1188/12.ONF.E468-E479

    authors: Wang Y,O'Connor M,Xu Y,Liu X

    更新日期:2012-11-01 00:00:00

  • Do oncology nurses provide more care to patients with high levels of emotional distress?

    abstract:PURPOSE/OBJECTIVES:To investigate nurses' planning and implementation of individualized patient care in relation to patients' emotional distress as assessed by nurses and whether nurses and patients perceived the implemented care in a similar manner. DESIGN:Prospective, comparative. SETTING:Five oncologic-hematologic...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:10.1188/10.ONF.E34-E42

    authors: Mårtensson G,Carlsson M,Lampic C

    更新日期:2010-01-01 00:00:00

  • Perceived Stress and the Fatigue Symptom Cluster in Childhood Brain Tumor Survivors.

    abstract:OBJECTIVES:To explore and estimate relationships among the elements of the symptom cluster in survivors of brain tumors aged 8-12 years during early survivorship. SAMPLE & SETTING:Child participants completed treatment at least six months and less than six years prior to enrollment at Children's Hospital of Alabam...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:10.1188/18.ONF.775-785

    authors: Johnson A,Rice M,Turner-Henson A,Haase JE,Azuero A

    更新日期:2018-11-01 00:00:00

  • Expressive writing in women with advanced breast cancer.

    abstract:PURPOSE/OBJECTIVES:To explore the relationships between patterns of affective word use (words with positive or negative connotations) in expressive writing conducted over four consecutive days and quality of life (QOL) three months after the writing exercise in women with metastatic breast cancer. DESIGN:Descriptive, ...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章,多中心研究

    doi:10.1188/07.ONF.1019-1024

    authors: Laccetti M

    更新日期:2007-09-01 00:00:00

  • Implementing evidence-based practice using an interprofessional team approach: part two.

    abstract::The complexity inherent in the inpatient oncology population requires effective interprofessional collaboration and integrated evidence-based practice (EBP), drawing from each of the disciplines to achieve desired outcomes. Each member of the team lends a strength and expertise that, when combined, often results in ou...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:10.1188/14.ONF.548-550

    authors: Bohnenkamp S,Pelton N,Rishel CJ,Kurtin S

    更新日期:2014-09-01 00:00:00

  • Heart Failure and Long-Term Survival Among Older Women With Breast Cancer

    abstract:Objectives:To evaluate the association between heart failure and overall survival up to 10 years after breast cancer diagnosis. Sample & Setting:Women aged 65 years or older diagnosed with invasive breast cancer, with and without self-reported heart failure, were examined for this retrospective cohort study using Surv...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:

    authors: Harrison JM,Friese CR,Barton DL,Janz NK,Pressler SJ,Davis MA

    更新日期:2018-01-02 00:00:00

  • Perspectives on Self-Advocacy: Comparing Perceived Uses, Benefits, and Drawbacks Among Survivors and Providers

    abstract:Purpose/Objectives:To describe and compare survivors' and providers' views of the uses of and perceived benefits and drawbacks of survivor self-advocacy. Design:A cross-sectional, two-group, mixed-methods survey. Setting:Survivors were recruited from local and national registries and advocacy organizations. Providers...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:10.1188/17.ONF.52-59

    authors: Hagan TH,Rosenzweig M,Zorn K,van Londen J,Donovan H

    更新日期:2017-01-03 00:00:00

  • The relationships among physiologic variables, quality of life, and fatigue in patients with multiple myeloma.

    abstract:PURPOSE/OBJECTIVES:To investigate the relationships among physiologic variables, fatigue, and quality of life (QOL) in patients with multiple myeloma. DESIGN:Cross-sectional, descriptive, exploratory. SETTING:Outpatient ambulatory care clinics at a tertiary oncology center. SAMPLE:56 patients with multiple myeloma w...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:10.1188/09.ONF.209-216

    authors: Booker R,Olson K,Pilarski LM,Noon JP,Bahlis NJ

    更新日期:2009-03-01 00:00:00

  • Measuring Clinical Decision Support Influence on Evidence-Based Nursing Practice.

    abstract:PURPOSE/OBJECTIVES:To measure the effect of clinical decision support (CDS) on oncology nurse evidence-based practice (EBP).
. DESIGN:Longitudinal cluster-randomized design.
. SETTING:Four distinctly separate oncology clinics associated with an academic medical center.
. SAMPLE:The study sample was comprised of rand...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:10.1188/16.ONF.E170-E177

    authors: Cortez S,Dietrich MS,Wells N

    更新日期:2016-07-01 00:00:00

  • Quality of life in long-term cancer survivors.

    abstract:PURPOSE/OBJECTIVES:To describe the quality of life (QOL) of long-term cancer survivors. DESIGN:Descriptive, mailed survey. SETTING:Membership of the National Coalition for Cancer Survivorship (NCCS), which is a nonprofit, peer-support network for people living with cancer. SAMPLE:687 (57%) of the 1,200 members of NC...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:

    authors: Ferrell BR,Dow KH,Leigh S,Ly J,Gulasekaram P

    更新日期:1995-07-01 00:00:00

  • Osteoporosis: a concern for cancer survivors.

    abstract:PURPOSE/OBJECTIVES:To describe the risk factors, prevention, diagnosis, management, and impact of osteoporosis on the lives of women who have survived breast and endometrial cancer. DATA SOURCES:Journal articles, selected textbooks, prescribing information, and conference proceedings. DATA SYNTHESIS:Women who have no...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章,评审

    doi:

    authors: Mahon SM

    更新日期:1998-06-01 00:00:00

  • The human genome exposed: a glimpse of promise, predicament, and impact on practice.

    abstract:PURPOSE/OBJECTIVES:To review basic gene biology, discuss current genetic advances, and project the potential impact of these advances on oncology nursing practice. DATA SOURCES:Published professional articles, tests, proceedings, governmental and lay publications. DATA SYNTHESIS:The Human Genome Project seeks to bett...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章,评审

    doi:

    authors: Engelking C

    更新日期:1995-03-01 00:00:00

  • Population-based cancer screening.

    abstract:PURPOSE/OBJECTIVES:To provide an overview of current issues surrounding the prevention of and screening for lung, breast, cervical, colorectal, ovarian, prostate, and skin cancer. DATA SOURCES:Original research, review articles, and published guidelines. DATA SYNTHESIS:Although morbidity and mortality rates have decr...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章,评审

    doi:10.1188/02.ONF.853-861

    authors: Champion VL,Rawl SM,Menon U

    更新日期:2002-06-01 00:00:00

  • An oncology unit's initiation of a bereavement support program.

    abstract:PURPOSE/OBJECTIVES:To describe how a multidisciplinary task force on an oncology unit developed and implemented a program offering educational and emotional support for recently bereaved families. DATA SOURCES:Published books and articles and bereavement support models. DATA SYNTHESIS:Program components included bere...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:

    authors: Burke C,Gerraughty SM

    更新日期:1994-11-01 00:00:00

  • Continuous infusion chemotherapy in the ambulatory setting: the nurse's role in patient selection and education.

    abstract::Continuous infusion therapy (CIT) is an alternative to traditional intravenous bolus or brief infusion chemotherapy. The benefits of CIT are improved therapeutic index, reduced toxicity, and modification of drug resistance. CIT administered in the ambulatory setting fosters cost effectiveness and improved patient sati...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:

    authors: Reville B,Almadrones L

    更新日期:1989-07-01 00:00:00

  • Day surgery for breast cancer: effects of a psychoeducational telephone intervention on functional status and emotional distress.

    abstract:PURPOSE/OBJECTIVES:To determine the efficacy of a nursing intervention based on self-regulation theory known as the Attentional Focus and Symptom Management Intervention (AFSMI) in enhancing physical and emotional well-being in women who underwent day surgery for breast cancer. DESIGN:Randomized clinical block trial; ...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1188/07.ONF.133-141

    authors: Allard NC

    更新日期:2007-01-01 00:00:00

  • Oncology nursing protocols: a step toward autonomy.

    abstract::Many professional nurses see the lack of autonomy, an essential element in the definition of a professional, as a deterrent to achieving true professional status. Autonomy in nursing is seen in the context of self-governance, shared governance, and nurses' participation in the decision-making process with regard to pa...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:

    authors: Rudolf VM

    更新日期:1989-09-01 00:00:00

  • Effects of exercise in combination with epoetin alfa during high-dose chemotherapy and autologous peripheral blood stem cell transplantation for multiple myeloma.

    abstract:PURPOSE/OBJECTIVES:To determine the effect of aerobic and strength resistance training and epoetin alfa (EPO) therapy on transfusions, stem cell collections, transplantation recovery, and multiple myeloma treatment response. DESIGN:Randomized clinical trial. SETTING:A myeloma research and therapy center in the south ...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章,随机对照试验

    doi:10.1188/08.ONF.E53-E61

    authors: Coleman EA,Coon SK,Kennedy RL,Lockhart KD,Stewart CB,Anaissie EJ,Barlogie B

    更新日期:2008-05-01 00:00:00

  • Priorities for oncology nursing research: the 2013 national survey.

    abstract:PURPOSE/OBJECTIVES:To advance the goals of evidence-based care and prioritize the knowledge generation that addresses contemporary challenges in oncology nursing. Results are used to inform the development of the Oncology Nursing Society (ONS) Research Agenda and by the ONS Foundation to develop strategic research init...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:10.1188/14.ONF.67-76

    authors: LoBiondo-Wood G,Brown CG,Knobf MT,Lyon D,Mallory G,Mitchell SA,Von Ah D,Wesmiller S,Fellman B

    更新日期:2014-01-01 00:00:00

  • Survivorship Care Plans and Treatment Summaries in Adult Patients With Hematologic Cancer: An Integrative Literature Review.

    abstract:PROBLEM IDENTIFICATION:Survivorship care plans (SCPs) and treatment summaries (TSs) have been recommended by the Institute of Medicine as ways to facilitate the delivery of holistic survivorship care. An integrative literature review was undertaken to identify current use of SCPs and TSs to meet the needs of survivors ...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章,评审

    doi:10.1188/15.ONF.283-291

    authors: Taylor K,Monterosso L

    更新日期:2015-05-01 00:00:00

  • Diagnosis, treatment, and nursing management of the patient with hemochromatosis.

    abstract::Hemochromatosis results when the body's iron stores progressively increase. Surplus iron stored in body tissues leads to organ dysfunction and death. Warnings that elevated iron stores increase the risk of cancer development necessitate a review of this condition. Two types of hemochromatosis, hereditary and secondary...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章,评审

    doi:

    authors: Keller JF,Blausey LA

    更新日期:1992-10-01 00:00:00

  • Response to "Nursing Care at the Time of Death: A Bathing and Honoring Practice"
.

    abstract::I am a nurse in a bone marrow transplantation unit at the University of Florida Health Shands Hospital in Gainesville. We are a high-risk center in the sense that we care for transplant patients who have been denied at other centers. Our patients are very sick with resistant disease and often with multiple comorbiditi...

    journal_title:Oncology nursing forum

    pub_type: 评论,信件

    doi:10.1188/17.ONF.10

    authors: Reveri L

    更新日期:2017-01-01 00:00:00

  • Nurses' compliance with American Cancer Society guidelines for cancer prevention and detection.

    abstract::This study aimed to ascertain the extent to which female nurses comply with American Cancer Society (ACS) guidelines and whether their rate of compliance is related to either age or education. A sample of 3,226 Florida nurses received the Health Habits Assessment Survey (HHAS), a nine-item questionnaire that assesses ...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章

    doi:

    authors: McMillan SC

    更新日期:1990-09-01 00:00:00

  • A pilot randomized trial evaluating low-level laser therapy as an alternative treatment to manual lymphatic drainage for breast cancer-related lymphedema.

    abstract:PURPOSE/OBJECTIVES:To examine the impact of advanced practice nurse (APN)-administered low-level laser therapy (LLLT) as both a stand-alone and complementary treatment for arm volume, symptoms, and quality of life (QOL) in women with breast cancer-related lymphedema. DESIGN:A three-group, pilot, randomized clinical tr...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章,随机对照试验

    doi:10.1188/13.ONF.383-393

    authors: Ridner SH,Poage-Hooper E,Kanar C,Doersam JK,Bond SM,Dietrich MS

    更新日期:2013-07-01 00:00:00

  • Temporary Stoppages and Burden of Treatment in Patients With Cancer.

    abstract:OBJECTIVES:To examine the effect of burden of treatment and multimorbidity on the relationship between baseline characteristics and oral oncolytic agent (OOA) temporary stoppages. SAMPLE & SETTING:272 patients newly prescribed OOAs at six National Cancer Institute-designated comprehensive cancer centers. METHODS ...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1188/19.ONF.E135-E144

    authors: Vachon E,Given B,Given C,Dunn S

    更新日期:2019-09-01 00:00:00

  • Internet cancer support groups: legal and ethical issues for nurse researchers.

    abstract:PURPOSE/OBJECTIVES:To explore the legal and ethical issues surrounding the use of information obtained from Internet cancer support groups (ICSGs) in research. DATA SOURCES:Published articles, news broadcasts, books, government reports. DATA SYNTHESIS:ICSGs are a rich source of information for people with cancer, the...

    journal_title:Oncology nursing forum

    pub_type: 杂志文章,评审

    doi:

    authors: Klemm P,Nolan MT

    更新日期:1998-05-01 00:00:00