Abstract：
:The daily production of melatonin from the pineal gland influences circadian and seasonal behaviour and physiology. To further understand how melatonin may function, it is important to characterize the receptor and signal transduction systems. Using the detergent digitonin, we were able to solubilize the receptor from the ovine pars tuberalis (PT) membrane. The receptor was isolated as a complex associated with its heterotrimeric G-protein. In the solubilized state, pre-bound 125I-2-iodomelatonin was stable at 4 degrees C, but was displaceable by GTP gamma S. The receptor-G-protein complex could be separated by molecular mass using native polyacrylamide gel electrophoresis. We demonstrate that the receptor-complex has a molecular mass of 525 kDa and differs from solubilized receptor-complexes isolated from either the lizard brain, chicken brain or the ovine hippocampus. Furthermore the receptor complex isolated from the hippocampus had the lowest molecular mass of these tissues (365 kDa) and was found not to be sensitive to GTP gamma S. This may indicate the existence of a distinct non-G-protein coupled form of the receptor.
journal_name
J Neuroendocrinoljournal_title
Journal of neuroendocrinologyauthors
Barrett P,MacLean A,Morgan PJdoi
10.1111/j.1365-2826.1994.tb00613.xsubject
Has Abstractpub_date
1994-10-01 00:00:00pages
509-15issue
5eissn
0953-8194issn
1365-2826journal_volume
6pub_type
杂志文章abstract：:The paraventricular nucleus (PVN) in the hypothalamus receives inputs from the hippocampus The present study explored the influence of the hippocampus on genes mediating glucocorticoid feedback in the PVN. Accordingly, the expression of mRNAs for corticotrophin-releasing hormone (CRH), the mineralocorticoid receptor (...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2006.01519.x
更新日期：2007-04-01 00:00:00
abstract：:Intravenous infusion of hypertonic saline increased plasma [Na (+) ] and osmolality and induced a short-latency drinking response. These changes were associated with increased glucose utilization in the supraoptic and paraventricular nuclei and neural lobe, and decreases in the medial septum and nucleus ambiguus. The ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1992.tb00162.x
更新日期：1992-04-01 00:00:00
abstract：:Recent studies in both animals and humans indicate that gonadal hormones have profound control over emotional states, and certainly contribute to the increased occurrence of psychiatric illness in women. Reports, as reviewed here, suggest that two important regions of the limbic system, the central nucleus of the amyg...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2826.2007.01552.x
更新日期：2007-06-01 00:00:00
abstract：:We studied the effect of corticosterone on interleukin (IL)-1 beta synthesis, body temperature, general activity, food consumption and fluid intake in rats treated with bacterial lipopolysaccharide (LPS). Radiotelemetry was used to assess body temperature and locomotor activity in combination with continuous automated...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1996.tb00833.x
更新日期：1996-02-01 00:00:00
abstract：:We have recently identified nip-2 as a gene target for 17beta-oestradiol activity in the neuroblastoma SK-ER3 cells expressing the oestrogen receptor (ER) alpha. Here we show 17beta-oestradiol treatment of neuroblastoma and rat embryo neurones in culture blocks the increase in nip-2 mRNA induced by apoptotic stimuli a...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2000.00541.x
更新日期：2000-11-01 00:00:00
abstract：:Seasonal animals use different strategies to reduce energy expenditure in the face of reduced seasonal food availability. For example, the ground squirrel enters a hibernation state with reduced metabolism, hypothermia and suppressed central nervous system activity, whereas the Djungarian hamster (Phodopus sungorus) e...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2007.01620.x
更新日期：2007-12-01 00:00:00
abstract：:Experimental arthritis induced by Freund-adjuvant administration is a model of chronic inflammation and rheumatoid arthritis associated with a decrease in pituitary growth hormone (GH) and hepatic insulin-like growth factor I (IGF-I) gene expression. Excessive nitric oxide (NO) synthesis by inducible NO synthase (iNOS...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2003.01117.x
更新日期：2003-12-01 00:00:00
abstract：:Following the cloning of the melanocortin receptor and agouti protein genes, a model was developed for the central melanocortin system with respect to the regulation of energy and glucose homeostasis. This model comprised leptin regulation of melanocortin peptides and agouti-related peptide (AgRP) produced from centra...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/jne.12285
更新日期：2015-06-01 00:00:00
abstract：:Unlike other mammals, including rodents, Old World primates and humans, common marmosets and probably all other New World primates synthesise and release chorionic gonadotrophin (CG), and not luteinising hormone (LH) from pituitary gonadotrophs. However, little is known about the physiological dynamics of gonadotrophi...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2007.01535.x
更新日期：2007-05-01 00:00:00
abstract：:Abstract Mouse monoclonal anti-vasopressin antibody was injected just above one hypothalamic paraventricular nucleus of the rat brain. Immunocytochemistry and morphometric analysis showed that the antibody was taken up by neurons with the size and stereotaxic distribution of vasopressin-producing neurons. Labelled neu...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1990.tb00418.x
更新日期：1990-06-01 00:00:00
abstract：:Immuno- and hybridization histochemical methods were used to examine a possible role for adrenocorticotropic hormone (ACTH) in regulating the expression of corticotropin-releasing peptides in rat hypothalamus. Densitometric assessments of relative levels of mRNAs encoding corticotropin releasing factor (CRF), arginine...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1995.tb00814.x
更新日期：1995-09-01 00:00:00
abstract：:Interleukin (IL)-6 has been involved in the control of body weight and body fat. Nevertheless, the mechanisms underlying these effects are not completely understood because central and peripheral actions of IL-6 are plausible. To gain further insight into the central effects of IL-6, we used transgenic mice expressing...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2011.02158.x
更新日期：2011-08-01 00:00:00
abstract：:The neurodevelopmental consequences of prenatal glucocorticoid exposure are not well-understood, particularly in species that give birth to neuroanatomically mature offspring. In the present study, we hypothesised that repeated prenatal glucocorticoid administration would alter hypothalamo-pituitary-adrenal (HPA) func...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2006.01517.x
更新日期：2007-03-01 00:00:00
abstract：:We have recently shown that impaired gastric motility observed in acute restraint stress was restored following repeated restraint stress in mice. Repeated restraint stress up-regulates oxytocin mRNA expression and down-regulates corticotrophin-releasing factor (CRF) mRNA expression at the hypothalamus. Oxytocin knock...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2010.02069.x
更新日期：2010-11-01 00:00:00
abstract：:In vivo glucocorticoid (GC) secretion exhibits a distinctive ultradian rhythmicity. The lipophilic hormone can rapidly diffuse into cells, although only the pulse peak is of sufficient amplitude to activate the low affinity glucocorticoid receptor (GR). Discrete pulses readily access brain regions such as the hippocam...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2010.02051.x
更新日期：2010-10-01 00:00:00
abstract：:When individuals undergo gestation in an obese dam, they are at increased risk for impairments in the ability of the brain to regulate body weight. In rodents, gestation in an obese dam leads to a number of changes to the development of the hypothalamic neurones that regulate body weight, including reduced neuronal co...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12556
更新日期：2017-12-01 00:00:00
abstract：:Abstract There is increasing evidence that the opioid inhibition of luteinizing hormone (LH) secretion is mediated, at least in part, by catecholaminergic mechanisms. This study determined the effects of selective manipulation of noradrenergic and adrenergic systems on the ability of opiate receptor blockade to induce...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1990.tb00395.x
更新日期：1990-02-01 00:00:00
abstract：:The central nervous system regulates and responds to endocrine signals, and this reciprocal relationship determines emotional processing and behavioural anxiety. Although the hypothalamic-pituitary-adrenal (HPA) axis remains the best-characterised system for this relationship, other steroid and peptide hormones are in...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/jne.12403
更新日期：2016-07-01 00:00:00
abstract：:Abstract Oxytocin- and vasopressin-binding sites were detected by autoradiography on films and on emulsion-coated sections of rat brains using highly selective [(125)|]-labelled oxytocin and vasopressin antagonists. Two distinct areas with high concentrations of oxytocin-binding sites were detected in the bed nucleus ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1991.tb00335.x
更新日期：1991-12-01 00:00:00
abstract：:This study examined whether gonadal steroids are involved in regulating galanin receptor 1 (GalR1) mRNA expression in neurones that contain oestrogen receptor alpha (ERalpha), in three regions of the preoptic area (POA) known to be involved in the control of gonadotropin secretion. Double-labelling immunohistochemistr...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.0953-8194.2004.01147.x
更新日期：2004-02-01 00:00:00
abstract：:Stimulation of the vagina and cervix, by mating or manual probing, elicits many behavioral and endocrine changes associated with female reproduction in rats. We and others have identified neurons in the medial preoptic area, medial division of the bed nucleus of the stria terminalis, posterodorsal portion of the media...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1994.tb00574.x
更新日期：1994-04-01 00:00:00
abstract：:Noradrenaline has been shown to modulate the ovarian-steroid feedback on luteinising-hormone (LH) release. However, despite the high amount of evidence accumulated over many years, the role of noradrenaline in LH regulation is still not clearly understood. The present study aimed to further investigate the involvement...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2009.01907.x
更新日期：2009-10-01 00:00:00
abstract：:The seasonal pattern of breeding in sheep offers an opportunity to examine plasticity of neuronal inputs to gonadotropin-releasing hormone (GnRH) neurones. We used conventional fluorescence microscopy and confocal microscopy to compare the extent of input to GnRH neurones from various neuropeptide/neurotransmitter sys...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2003.01030.x
更新日期：2003-05-01 00:00:00
abstract：:In vitro, estrogens stimulate corticotropin-releasing factor (CRF) gene transcription. In ovariectomized (OVX) rats, estrogens have a negative effect on CRF mRNA levels in the hypothalamic paraventricular nucleus. This suggests that the stimulatory influence of estrogens found in vitro may be masked in vivo by an inhi...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1996.04835.x
更新日期：1996-07-01 00:00:00
abstract：:Identification of kisspeptin (Kiss1) and its G protein-coupled receptor 54 (Kiss1r) as an essential component of the hypothalamic-pituitary-gonadal (HPG) axis controlling gonadotrophin secretion raises the possibility that kisspeptin-Kiss1r signalling may play a critical role in the transduction of stress-induced supp...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2008.01807.x
更新日期：2009-01-01 00:00:00
abstract：:It is now clear that oestrogens are not only circulating reproductive hormones, but that they also have neurotransmitter-like properties in a wide range of brain circuits. The view of oestrogens as intrinsic neuromodulators that shape behaviour has been bolstered by a series of recent developments from multiple verteb...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/jne.12055
更新日期：2013-11-01 00:00:00
abstract：:Leptin signalling in the hypothalamus is critical for the maintenance of normal body weight. Although hyperleptinaemia in obese people suggests a state of leptin resistance, and diet-induced obesity in rodents is associated with central leptin resistance, the underlying mechanisms remain unclear. Recent evidence sugge...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2005.01362.x
更新日期：2005-11-01 00:00:00
abstract：:Among all mammalian species, pups are highly dependent on their mother not only for nutrition, but also for physical interaction. Therefore, disruption of the mother-pup interaction changes the physiology and behaviour of pups. We review how maternal separation in the early developmental period brings about changes in...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2826.2009.01837.x
更新日期：2009-03-01 00:00:00
abstract：:Lipopolysaccharide (LPS), an endotoxin produced by gram-negative bacteria, inhibits gonadotrophin secretion and ovulation in female mammals. The present study was undertaken to examine whether gamma-aminobutyric acid (GABA)-synthesising neurones in the medial preoptic area (mPOA) may be involved in the inhibition by L...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2005.01358.x
更新日期：2005-10-01 00:00:00
abstract：:The anteroventral periventricular nucleus (AVPV) is sexually dimorphic, presenting a higher neuronal density in females. The AVPV contains a dense collection of oestrogen and progesterone receptors and has been related to the modulation of gonadotrophin-releasing hormone (GnRH) secretion and gene expression in respons...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2006.01457.x
更新日期：2006-09-01 00:00:00
