Abstract：
:Recent studies in both animals and humans indicate that gonadal hormones have profound control over emotional states, and certainly contribute to the increased occurrence of psychiatric illness in women. Reports, as reviewed here, suggest that two important regions of the limbic system, the central nucleus of the amygdala (CeA) and the bed nucleus of the stria terminalis (BNST), control different aspects of emotional behaviour. Short-term cue-specific emotional responses, like Pavlovian fear conditioning, require activation of the CeA, while long-duration and contextual emotional responses, are dependant on the BNST. There is accumulating experimental evidence that gender and sex hormones specifically modulate BNST-mediated anxiety behaviours. Moreover, the functional separation between the CeA and the BNST may be exaggerated during lactation in the rat, a time of profound hormonal and behavioural change. In this study, the effects of sex hormones on fear and anxiety are reviewed with an emphasis on the differential effects of these hormones on functions subserved by the BNST as opposed to the CeA. Studies, as highlighted here, looking at sex hormone and gender effects on the ability of corticotrophin-releasing factor and bright ambient light to enhance startle, emphasise the importance of understanding both the effect of, and brain region where, gonadal hormones exert their control over emotional behaviour.
journal_name
J Neuroendocrinoljournal_title
Journal of neuroendocrinologyauthors
Toufexis Ddoi
10.1111/j.1365-2826.2007.01552.xsubject
Has Abstractpub_date
2007-06-01 00:00:00pages
461-73issue
6eissn
0953-8194issn
1365-2826pii
JNE1552journal_volume
19pub_type
杂志文章,评审abstract：:Stress exposure during early-life development can programme individual brain and physiology. The hypothalamic-pituitary-adrenal (HPA) axis is one of the primary targets of this programming, which is generally associated with a hyperactive HPA axis, indicative of a reduced negative-feedback. This reduced feedback effic...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12228
更新日期：2014-12-01 00:00:00
abstract：:Insulin-like growth factor I (IGF-I) and its receptor are present in human and rat anterior pituitary. However, few data exist on the potential presence of IGF-I or its receptor in the non-mammalian pituitary and the cellular sites of IGF-I production have not been identified in any species. Thus, we investigated the ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2000.00464.x
更新日期：2000-05-01 00:00:00
abstract：:Chronic stress early in postnatal life influences hormonal and behavioural responses to stress persistently, but the mechanisms and molecular cascades that are involved in this process have not been clarified. To approach these issues, a chronic stress paradigm for the neonatal rat, using limited bedding material to a...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2001.00698.x
更新日期：2001-09-01 00:00:00
abstract：:Sex steroids and growth factors interact at the intracellular level in a variety of tissues to control numerous physiological functions. Oestrogen is known to stimulate prolactin synthesis and secretion, but the effect of insulin-like growth factor (IGF)-I is less clear. We used GH3 cells, a somatolactotroph cell line...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2005.01283.x
更新日期：2005-02-01 00:00:00
abstract：:Women are twice as likely to suffer from mood disorders than men. Moreover, a growing body of evidence suggests a reciprocal modulation between sex steroids and the serotonin (5-HT) system. A previous study from our laboratory has shown that the progesterone metabolites 5beta-pregnane-3,20-dione (5beta-DHP) and 5alpha...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2005.01292.x
更新日期：2005-03-01 00:00:00
abstract：:Recent findings relate obesity to inflammation in key hypothalamic areas for body weight control. Hypothalamic inflammation has also been related to oxidative stress. Palmitic acid (PA) is the most abundant free fatty acid found in food, and in vitro studies indicate that it triggers a pro-inflammatory response in the...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12673
更新日期：2019-02-01 00:00:00
abstract：:Motherhood induces a series of adaptations in the physiology of the female, including an increase of maternal brain plasticity and a reduction of cell damage in the hippocampus caused by kainic acid (KA) excitotoxicity. We analysed the role of lactation in glial activation in the hippocampal fields of virgin and lacta...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12028
更新日期：2013-06-01 00:00:00
abstract：:In addition to its established lactational roles, prolactin acts on multiple target tissues and its circulating levels are responsive to a range of physiological stimuli. The present study used immunohistochemistry to demonstrate that systemic administration of prolactin activates target cells in the arcuate nucleus a...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12733
更新日期：2019-06-01 00:00:00
abstract：:Ghrelin, an orexigenic hormone released from the empty stomach, provides a gut-brain signal that promotes many appetitive behaviours, including anticipatory and goal-directed behaviours for palatable treats high in sugar and/or fat. In the present study, we aimed to determine whether ghrelin is able to influence and/o...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12463
更新日期：2017-04-01 00:00:00
abstract：:We have examined alterations in the hypothalamo-pituitary GH-somatic growth axis and the hypothalamo-pituitary LH-ovarian axis in a line of transgenic ICR mice expressing human GH (hGH) under the influence of the whey acid protein promoter. Transgenic female mice weighed twice as much as control females and were infer...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1997.00612.x
更新日期：1997-08-01 00:00:00
abstract：:In the present study, we investigated the effects of the cannabinoid receptor agonist CP55,940 on excitatory and inhibitory synaptic transmission in the rat supraoptic nucleus. Whole-cell patch clamp recordings were performed on supraoptic neurones in in vitro brain slice preparations. CP55,940 significantly reduced t...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2005.01350.x
更新日期：2005-09-01 00:00:00
abstract：:Estrogen is known to play an important role in regulating reproductive function in female rats through actions exerted at the preoptic area, a part of the brain that is markedly sexually dimorphic and which contains abundant estrogen receptors. A critical question to our understanding of estrogen's action on the brain...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1994.tb00557.x
更新日期：1994-02-01 00:00:00
abstract：:Depolarisation-secretion coupling is assumed to be dependent only on extracellular calcium ([Ca2+ ]o ). Ryanodine receptor (RyR)-sensitive stores in hypothalamic neurohypophysial system (HNS) terminals produce sparks of intracellular calcium ([Ca2+ ]i ) that are voltage-dependent. We hypothesised that voltage-elicited...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12840
更新日期：2020-04-01 00:00:00
abstract：:Neonatal rats were daily injected with 100 microg/kg T4 and killed at 4, 8 or 15 days. Circulating corticosterone and corticosteroid binding globulin concentrations increased in 8- and 15-day-old rats after T4 treatment. Plasma adrenocorticotropic hormone (ACTH) concentrations, pituitary ACTH content and pro-opiomelan...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2000.00520.x
更新日期：2000-08-01 00:00:00
abstract：:Oxytocin and vasopressin reduce the amplitude of excitatory postsynaptic responses in magnocellular neuroendocrine cells of the supraoptic nucleus (SON). To test whether synaptic glutamate release is modulated by these neuropeptides, we examined the combined effect of vasopressin and oxytocin on depolarization-induced...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2003.00976.x
更新日期：2003-02-01 00:00:00
abstract：:Puberty in the male Syrian hamster (Mesocricetus auratus) is characterized by decreased responsiveness to testosterone mediated negative feedback, but the neural mechanism for this change remains elusive. We hypothesized that decreased inhibition of the gonadotropin-releasing hormone (GnRH) system results in increased...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1999.00376.x
更新日期：1999-08-01 00:00:00
abstract：:Serotonin (5-HT) plays a role in mediating the oestradiol-induced surge of luteinising hormone (LH), but so far the 5-HT receptor subtype involved has not been identified. Our previous in-situ hybridization and pharmacological studies suggest that the action of 5-HT involves the 5-HT2A receptor. The aim of the present...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1999.00299.x
更新日期：1999-01-01 00:00:00
abstract：:The unravelling of the genetic basis of the hypogonadotrophic hypogonadal disorders, including Kallmann syndrome (KS), has led to renewed interest into the developmental biology of gonadotrophin-releasing hormone (GnRH) neurones and, more generally, into the molecular mechanisms of reproduction. KS is characterised by...
journal_title：Journal of neuroendocrinology
pub_type： 历史文章,杂志文章,评审
doi：10.1111/j.1365-2826.2007.01627.x
更新日期：2008-02-01 00:00:00
abstract：:It is becoming well established that the gut microbiome has a profound impact on human health and disease. In this review, we explore how steroids can influence the gut microbiota and, in turn, how the gut microbiota can influence hormone levels. Within the context of the gut microbiome-brain axis, we discuss how pert...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/jne.12548
更新日期：2018-02-01 00:00:00
abstract：:The interaction of animals with conspecifics, termed social behaviour, has a major impact on the survival of many vertebrate species. Neuropeptide hormones modulate the underlying physiology that governs social interactions, and many findings concerning the neuroendocrine mechanisms of social behaviours have been extr...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/jne.12807
更新日期：2019-12-01 00:00:00
abstract：:The neural and neurochemical substrates regulating reproduction in birds remain vaguely defined. The findings that electrical stimulation in the medial preoptic area (ES/MPOA) or intracerebroventricular infusion of dopamine (DA) stimulated luteinising hormone (LH) and prolactin (PRL) release in female turkeys, led to ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2006.01443.x
更新日期：2006-07-01 00:00:00
abstract：:Abstract The experiments reported on here were conducted to test the hypothesis that sexual behaviour in the female musk shrew (Suncus murinus) is regulated by the neural aromatization of testosterone to oestradiol. In the first experiment ovariectomized animals received subcutaneous hormone implants containing either...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1991.tb00301.x
更新日期：1991-08-01 00:00:00
abstract：:Much progress has been made during the past 30 years with respect to elucidating the neural and endocrine pathways by which bodily needs for water and energy are brought to conscious awareness through the generation of thirst and hunger. One way that circulating hormones influence thirst and hunger is by acting on neu...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/jne.12689
更新日期：2019-03-01 00:00:00
abstract：:The impairment in arginine vasopressin (AVP) secretion during sepsis is described in clinical and experimental studies and has been associated with oxidative stress, apoptosis, and diminished activation of hypothalamic neurons. Few studies have, however, assessed these abnormalities in sepsis survivors. Here we perfor...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12604
更新日期：2018-05-01 00:00:00
abstract：:Gonadotrophin-releasing hormone (GnRH) regulates reproduction via binding a G-protein coupled receptor on the surface of the gonadotroph, through which it transmits signals, mostly via the mitogen-activated protein (MAPK) cascade, to increase synthesis of the gonadotrophin hormones: luteinising hormone (LH) and follic...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2826.2012.02359.x
更新日期：2012-12-01 00:00:00
abstract：:Novel approaches to the characterization of coding carried by spike trains are discussed. Measuring firing frequency alone may only partially reflect spike patterning, and can only quantify changes of the most obvious kind. We have devised a method that combines probabilistic and information approaches to quantify the...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/j.0953-8194.2004.01166.x
更新日期：2004-04-01 00:00:00
abstract：:The present study was conducted to visualize neuropeptides in the SCN of a mustelid, the American mink in which seasonal cycles of reproduction rely totally on the annual changes in day length. At this time, data in mustelids are lacking. Results were obtained with in situ hybridization (ISH) using synthetic oligonucl...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1995.tb00669.x
更新日期：1995-01-01 00:00:00
abstract：:There is no information on the neuroanatomical distribution of the progesterone receptor (PR) in the rabbit. Therefore, we mapped the distribution of PR-immunoreactive cells in the forebrain of ovariectomized female rabbits. Vehicle-injected ovariectomized rabbits showed PR-immunoreactive cells only in the infundibula...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2003.01070.x
更新日期：2003-09-01 00:00:00
abstract：:Regulation of pituitary gonadotrophins by the decapeptide gonadotrophin-releasing hormone 1 (GnRH1) is crucial for the development and maintenance of reproductive functions. A common amino acid sequence for this decapeptide, designated as 'mammalian' GnRH, has been identified in all mammals thus far investigated with ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2005.01307.x
更新日期：2005-05-01 00:00:00
abstract：:Recent studies have revealed the occurrence of five first exon variants of the rat prolactin receptor mRNA, suggesting that multiple promoters direct prolactin receptor transcription in response to different regulatory factors. In the present study, regional expression of these first exon variants, as well as two prol...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2007.01565.x
更新日期：2007-08-01 00:00:00
