The effect of fluoxetine on sleep: a longitudinal, double-blind polysomnographic study of healthy volunteers.

Abstract:

:Fluoxetine, a selective inhibitor of serotonin (5-HT) uptake, was compared with placebo in a randomized double-blind longitudinal trial in 12 healthy volunteers. Sleep polygraphic recordings were performed at home twice before and once after 6 days of medication. After 6 days fluoxetine significantly decreased the amount of rapid eye movement (REM) sleep. The sleep-onset latency and REM latency were increased, but there was no significant increase in the amount of awakenings during night. The relative proportion of stages 2 and 3 increased after fluoxetine administration, although there was no significant change with regard to total amount of slow-wave sleep. Fluoxetine did not induce prominent eye movements during non-rapid eye movement (NREM) sleep in this study. Results of the subjective assessment revealed tendencies of improved sleep and well-being in the fluoxetine group. It is concluded that a comparatively small dose of fluoxetine (20 mg/day) causes the same type of changes in REM sleep which are characteristic of most antidepressive drugs.

authors

Vasar V,Appelberg B,Rimón R,Selvaratnam J

doi

10.1097/00004850-199409000-00009

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

203-6

issue

3

eissn

0268-1315

issn

1473-5857

journal_volume

9

pub_type

临床试验,杂志文章,随机对照试验
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