Cardiovascular effects of carbamazepine toxicity.

Abstract:

STUDY OBJECTIVE:To evaluate the cardiovascular effects of carbamazepine in patients presenting to the emergency department. DESIGN:A retrospective case series from February 1, 1985, to July 30, 1993. SETTING:Six urban EDs. PARTICIPANTS:Seventy-two adult and pediatric patients with serum carbamazepine concentrations greater than 12 micrograms/mL and concurrent 12-lead ECGs. RESULTS:The mean carbamazepine level was 24 micrograms/mL (range, 12.6 to 55 micrograms/mL). Minor ECG abnormalities were noted but no clinically significant arrhythmias were found. No correlation was found between carbamazepine concentration and heart rate or PR, QRS, or corrected QT intervals. Four adult patients had transient hypotension. CONCLUSION:Clinically significant cardiovascular toxicity occurs rarely in patients with toxic carbamazepine concentrations. ECG findings do not correlate with serum carbamazepine concentration.

journal_name

Ann Emerg Med

authors

Apfelbaum JD,Caravati EM,Kerns WP 2nd,Bossart PJ,Larsen G

doi

10.1016/s0196-0644(95)70176-1

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

631-5

issue

5

eissn

0196-0644

issn

1097-6760

pii

S0196-0644(95)70176-1

journal_volume

25

pub_type

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