Translaryngeal absorption of lidocaine.

Abstract:

:Our study was conducted to determine the appropriate dose of lidocaine using the larynx and to characterize the onset and duration of therapeutic serum levels. A mean dose of 5.67 +/- 1.2 mg/kg was topically administered to the subglottic region of seven comatose patients through a cricothyroid membrane puncture. Serial serum lidocaine levels showed that therapeutic levels were attained in 5.1 +/- 3.2 minutes with a mean maximum level of 3.16 +/- 1.52 micrograms/ml and were reached at 18.71 +/- 8.71 minutes. Therapeutic serum levels were maintained for 68.4 +/- 29.7 minutes. Absorption of lidocaine via the airway yields sustained levels, although the duration of onset is less rapid and the maximum serum level is lower than that from an equivalent intravenous dose.

journal_name

Ann Emerg Med

authors

Boster SR,Danzl DF,Madden RJ,Jarboe CH

doi

10.1016/s0196-0644(82)80062-0

subject

Has Abstract

pub_date

1982-09-01 00:00:00

pages

461-5

issue

9

eissn

0196-0644

issn

1097-6760

pii

S0196-0644(82)80062-0

journal_volume

11

pub_type

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