当前位置： SCI文献检索 > ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION期刊下所有文献 > High-voltage pulsed current: its influence on diameters of histamine-dilated arterioles in hamster cheek pouches.

High-voltage pulsed current: its influence on diameters of histamine-dilated arterioles in hamster cheek pouches.

Abstract：

:Results from five independent studies from our laboratory indicate that cathodal high-voltage pulsed current (HVPC) significantly curbs posttraumatic edema formation in several animal models. Conversely, anodal HVPC did not curb edema formation. The mechanism by which HVPC reduces edema formation is unknown. We hypothesize that HVPC causes a decrease in local blood flow by active vasoconstriction of arterioles. Because we had previously observed positive effects with cathodal HVPC but not anodal HVPC, we further hypothesized that cathodal but not anodal HVPC would reduce diameters of histamine-dilated arterioles. Changes in diameters of resistance arterioles (5 to 30 microns internal diameter) were measured directly in cheek pouches of anesthetized hamsters, using in vivo video microscopy. Three minutes after superfusion with the inflammatory mediator (histamine) was begun, sensory-level HVPC at 120pps was applied concurrently for 30 minutes. Five animals received cathodal HVPC and five received anodal HVPC. Four other animals received 30-minute treatments of both cathodal and anodal HVPC in random order. Three control animals received histamine without HVPC for 30 minutes. Diameter changes of one arteriole from each cheek pouch was measured every 20 seconds throughout the treatment period. One-way analysis of variance (ANOVA) with repeated measures showed that diameters of histamine-dilated controls varied little over 30 minutes, and that adding cathodal HVPC did not significantly alter diameters of arterioles superfused with histamine. However, applying anodal HVPC to histamine-dilated arterioles significantly reduced arteriolar diameters. These results do not support the hypothesis that cathodal HVPC curbs edema formation by increasing arteriolar tone in the injured area.

journal_name

Arch Phys Med Rehabil

journal_title

Archives of physical medicine and rehabilitation

authors

Karnes JL,Mendel FC,Fish DR,Burton HW

doi

10.1016/s0003-9993(95)80665-2

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

381-6

issue

eissn

0003-9993

issn

1532-821X

pii

S0003-9993(95)80665-2

journal_volume

pub_type

杂志文章

在线工具

High-voltage pulsed current: its influence on diameters of histamine-dilated arterioles in hamster cheek pouches.