Abstract:
:EEG oscillations are hypothesized to reflect cyclical variations in the neuronal excitability, with particular frequency bands reflecting differing spatial scales of brain operation. However, despite decades of clinical and scientific investigation, there is no unifying theory of EEG organization, and the role of ongoing activity in sensory processing remains controversial. This study analyzed laminar profiles of synaptic activity [current source density CSD] and multiunit activity (MUA), both spontaneous and stimulus-driven, in primary auditory cortex of awake macaque monkeys. Our results reveal that the EEG is hierarchically organized; delta (1-4 Hz) phase modulates theta (4-10 Hz) amplitude, and theta phase modulates gamma (30-50 Hz) amplitude. This oscillatory hierarchy controls baseline excitability and thus stimulus-related responses in a neuronal ensemble. We propose that the hierarchical organization of ambient oscillatory activity allows auditory cortex to structure its temporal activity pattern so as to optimize the processing of rhythmic inputs.
journal_name
J Neurophysioljournal_title
Journal of neurophysiologyauthors
Lakatos P,Shah AS,Knuth KH,Ulbert I,Karmos G,Schroeder CEdoi
10.1152/jn.00263.2005subject
Has Abstractpub_date
2005-09-01 00:00:00pages
1904-11issue
3eissn
0022-3077issn
1522-1598pii
00263.2005journal_volume
94pub_type
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