Abstract：
BACKGROUND:Recent studies in adults have shown that polymeric (whole protein) diets are as effective as semi-elemental and elemental formulae for the induction of remission in small bowel Crohn's disease. Whole protein diets are more palatable and cheaper. There have been no studies confirming efficacy in children. PATIENTS AND METHODS:We report our experience with seven children with active small bowel Crohn's disease given a casein-based, polymeric feed rich in TGF-beta 2 (Specific Polymeric Diet; Nestle-Clintec; Vevey, Switzerland) as complete nutrition for 8 weeks. RESULTS:Initial and follow-up assessments were performed. All children showed a significant improvement in disease activity, with C-reactive protein returning to normal, an increase in serum albumin and a good weight gain. Initial and follow-up ileal biopsies were assessed and showed reduced mucosal inflammation in six of seven children, with complete healing in two. CONCLUSION:In an uncontrolled descriptive study we have shown that a polymeric (whole protein) diet is a therapeutic option for small bowel Crohn's disease in children. By comprehensive follow-up we have demonstrated clinical and biochemical remission, with an improved endoscopic appearance and a reduction of mucosal inflammation in the terminal ileum.
journal_name
Aliment Pharmacol Therjournal_title
Alimentary pharmacology & therapeuticsauthors
Beattie RM,Schiffrin EJ,Donnet-Hughes A,Huggett AC,Domizio P,MacDonald TT,Walker-Smith JAdoi
10.1111/j.1365-2036.1994.tb00338.xsubject
Has Abstractpub_date
1994-12-01 00:00:00pages
609-15issue
6eissn
0269-2813issn
1365-2036journal_volume
8pub_type
杂志文章abstract：BACKGROUND:Distal ulcerative colitis may prove to be resistant to steroids and aminosalicylates, but total colectomy is more difficult to justify than in severe extensive colitis. Immunosuppression is of established benefit in generalized colitis, but there are no data available specific to distal disease. AIM:To dete...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2036.2002.01170.x
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:The eradication rates following standard triple therapy for Helicobacter pylori infection are declining worldwide. Recent studies have shown that sequential therapy for H. pylori infection yields high cure rates. AIM:To compare the efficacy and tolerability of a sequential regimen as first-line treatment of...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1365-2036.2011.04902.x
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Proton pump inhibitors are effective for the healing of oesophagitis. Standard doses of omeprazole, lansoprazole or pantoprazole are sufficient for healing in mild to moderate cases of oesophagitis. AIM:To compare the efficacy of double the standard doses of omeprazole, lansoprazole or pantoprazole for main...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2036.1998.00278.x
更新日期：1998-01-01 00:00:00
abstract：:As the relative efficacy of therapeutic agents in the treatment of gastro-oesophageal reflux disease is related to how consistently and completely gastric acid secretion is suppressed, intragastric pH monitoring is a useful tool in stratifying therapies. If there is no acid in the stomach, there can be none to reflux ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2004.02135.x
更新日期：2004-10-01 00:00:00
abstract：AIM:To determine whether misoprostol promotes the healing of non-steroidal anti-inflammatory drug-induced gastroduodenal lesions in a human experimental model. METHODS:Mucosal damage and healing of mucosal biopsy sites were assessed endoscopically in 10 healthy, Helicobacter pylori-negative volunteers with a normal in...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-2036.1996.29171000.x
更新日期：1996-08-01 00:00:00
abstract：BACKGROUND:Even in the biologic era, corticosteroid dependency in IBD patients is common and causes a lot of morbidity, but methods of withdrawal are not well described. AIM:To assess the effectiveness of a corticosteroid withdrawal method. METHODS:Twelve patients (10 men, 2 women; 6 ulcerative colitis, 6 Crohn's dis...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2009.04136.x
更新日期：2009-11-15 00:00:00
abstract：BACKGROUND:Although a few adult cases of fulminant-type autoimmune hepatitis have been reported, their clinical features and prognosis have remained uncertain. AIM:To assess the clinical features and prognosis of patients with fulminant-type autoimmune hepatitis. METHODS:Eleven patients (10%) diagnosed with fulminant...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2006.02894.x
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:Direct antiviral therapies for chronic hepatitis C virus (HCV) infection have expanded treatment options for neglected patient populations, including elderly patients who are ineligible/intolerant to receive interferon (IFN)-based therapy. AIM:To investigate the efficacy, tolerability and potential for drug...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.13769
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Autoimmune atrophic gastritis (AAG) is characterised by a wide clinical spectrum that could delay its diagnosis. AIMS:To quantify the diagnostic delay in patients suffering from AAG and to explore possible risk factors for longer diagnostic delay. METHODS:Consecutive patients with AAG evaluated at our gast...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.15317
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:The safety and survival benefit of transcatheter arterial chemoembolization for patients with huge hepatocellular carcinoma is uncertain. AIM:To evaluate the role of embolization in unresectable hepatocellular carcinomas larger than 10 cm. METHODS:Twenty-six consecutive patients who had an unresectable hep...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2006.02704.x
更新日期：2006-01-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2036.2001.01065.x
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:Interferon (IFN-alpha)-based regimens have been used with varying success in the treatment of chronic hepatitis C (CHC) for over two decades. The effect of such treatments on the natural course of CHC has been evaluated in small clinical trials with conflicting results. AIM:To investigate the natural course...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1365-2036.2009.03974.x
更新日期：2009-05-15 00:00:00
abstract：BACKGROUND:The increasing incidence of Clostridium difficile (C. difficile) infection (CDI) among patients with inflammatory bowel disease is well recognised. However, most studies have focused on demonstrating that CDI is associated with adverse outcomes in IBD patients. Few have attempted to identify predictors of se...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1365-2036.2012.05022.x
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Non-steroidal anti-inflammatory drugs have been implicated in reports of liver injury. However, the precise risk of non-steroidal anti-inflammatory drugs for this rare complication is unknown. AIM:To review systematically the published literature of population-based epidemiological studies reporting the inc...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2004.02092.x
更新日期：2004-08-15 00:00:00
abstract：BACKGROUND:As there is considerable overlap between the fasting serum gastrin concentrations found in Zollinger-Ellison syndrome and various common conditions such as Helicobacter pylori infection and acid suppressing medication use, establishing the cause of hypergastrinaemia in individual cases can sometimes be diffi...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2009.03976.x
更新日期：2009-05-15 00:00:00
abstract：BACKGROUND:Proton pump inhibitors including omeprazole and lansoprazole inhibit gastric acid secretion by selectively and non-competitively inactivating the H+, K+ ATPase molecules of the parietal cell, but possibly only those that are actively secreting acid. This might imply that stimulation of acid secretion by a me...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2036.2000.00829.x
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:Ranitidine 75 mg (Zantac 75) has been shown to be effective for the treatment of pre-existing heartburn symptoms. AIM:To compare the efficacy of dosing ranitidine 75 mg or placebo 30 min prior to a proven heartburn-provoking meal in completely preventing or reducing subsequent heartburn symptoms. METHODS:A...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2036.1999.00505.x
更新日期：1999-04-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2036.1989.tb00193.x
更新日期：1989-02-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1111/apt.14818
更新日期：2018-07-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,meta分析
doi：10.1111/apt.14840
更新日期：2018-08-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.1991.tb00004.x
更新日期：1991-02-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2036.1997.84256000.x
更新日期：1997-02-01 00:00:00
abstract：BACKGROUND:Oral aloe vera gel is widely used by patients with inflammatory bowel disease and is under therapeutic evaluation for this condition. AIM:To assess the effects of aloe vera in vitro on the production of reactive oxygen metabolites, eicosanoids and interleukin-8, all of which may be pathogenic in inflammator...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2004.01874.x
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:Delta virus (HDV)-related chronic hepatitis is difficult to treat. AIMS:To evaluate the efficacy of lamivudine 100 mg daily on serum HDV-RNA, hepatitis D virus antibodies and alanine aminotransferase levels, liver histology, and on hepatitis B surface antigen seroconversion. METHODS:Thirty-one hepatitis B ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1365-2036.2005.02542.x
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:Studies have shown that past alcohol consumption reduces response rates in patients with chronic hepatitis C treated with interferon monotherapy. AIM:To clarify the importance of alcohol consumption on response rates in patients undergoing treatment with pegylated interferon and ribavirin. METHODS:In a sin...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2005.02631.x
更新日期：2005-10-15 00:00:00
abstract：AIM:To assess the efficacy and tolerance of sodium alginate compared to cisapride in patients suffering from reflux symptoms, without severe oesophagitis. METHODS:A total of 353 patients with symptoms of reflux oesophagitis (average age 40 years, 51% men, 33% smokers, 43% consumers of alcoholic drinks) were selected a...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1046/j.1365-2036.1998.00283.x
更新日期：1998-02-01 00:00:00
abstract：BACKGROUND:There is clear benefit from combination therapy with infliximab and immunosuppressive drugs (IS), but few data are available for adalimumab (ADA). AIM:To assess the efficacy of ADA monotherapy and ADA+IS for induction and maintenance therapy in Crohn's disease. METHODS:Retrospective study of patients with ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.12076
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Anti-TNFα agents have revolutionised management of chronic inflammatory diseases. Paradoxically, these agents might provoke development of de novo autoimmune diseases. AIM:To examine whether there is an increased risk of developing Crohn's disease (CD) and ulcerative colitis (UC) while under treatment with ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.15370
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Although the role of asbestos in the genesis of mesothelioma and primary bronchopulmonary cancers has been established, results from studies focusing on the relationship between occupational exposure to asbestos and digestive cancer remain contradictory. AIM:To determine whether occupational asbestos exposu...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2009.04050.x
更新日期：2009-08-15 00:00:00
abstract：:The decision regarding prophylactic treatment after surgery in Crohn's disease (CD) requires a good estimation of the risk of recurrence. It is also important to consider the consequences of recurrence for the patient, and the risks and benefits of treatment, bearing in mind that it will be given over a long period. S...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2006.03055.x
更新日期：2006-10-01 00:00:00
