Primary diagnosis of malignant mesothelioma by fine-needle aspiration of a supraclavicular lymph node.

Abstract:

:Malignant mesothelioma is a rare neoplasm with poor prognosis. The pleural form is defined as a malignant tumor of mesothelial cells with a diffuse growth pattern involving the visceral and parietal surfaces of the pleura. To our knowledge, there have only been two reported cases in the literature where fine-needle aspiration (FNA) of a lymph node was the primary mode of diagnosis of malignant mesothelioma. We describe a 40-yr-old male in whom the primary diagnosis of malignant mesothelioma was made by FNA of a supraclavicular lymph node. The mesothelial origin of the tumor was confirmed with immunohistochemical studies. A pleural biopsy immediately preceding the FNA was interpreted as chronic inflammation. Most patients with clinically documented lymph node metastases of malignant mesothelioma have had a previously established diagnosis of mesothelioma. Our case demonstrates that FNA can be a simple and invaluable method of diagnosis in those unusual cases where diagnosis of malignant mesothelioma has not already been made before lymphadenopathy.

journal_name

Diagn Cytopathol

journal_title

Diagnostic cytopathology

authors

Tafazzoli A,Raza A,Martin SE

doi

10.1002/dc.20314

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

122-5

issue

2

eissn

8755-1039

issn

1097-0339

journal_volume

33

pub_type

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