Nitric oxide: an overview.

Abstract:

:Nitric oxide (NO), a paracrine-acting gas enzymatically synthesized from L-arginine, is a unique biologic mediator that has been implicated in a myriad of physiologic and pathophysiologic states. It is an important regulator of vascular tone and may be the mediator of the hemodynamic changes involved in sepsis and cirrhosis. In addition, there is increasing evidence that NO is involved in coagulation, immune function, inhibitory innervation of the gastrointestinal tract, protection of gastrointestinal mucosa, and the hepatotoxicity of cirrhosis. It has already been speculated that NO may represent a point of control or intervention in a number of disease states. The purpose of this paper is to provide the surgeon with a broad overview of the scientific and clinical aspects of this important molecule.

journal_name

Am J Surg

authors

Rodeberg DA,Chaet MS,Bass RC,Arkovitz MS,Garcia VF

doi

10.1016/s0002-9610(05)80017-0

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

292-303

issue

3

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(05)80017-0

journal_volume

170

pub_type

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