Can parathyroid hyperplasia be predicted preoperatively?

Abstract:

INTRODUCTION:The purpose of this study was to determine if there are clinical features that raise suspicion for parathyroid hyperplasia. MATERIALS & METHODS:We retrospectively reviewed patients with primary hyperparathyroidism who underwent parathyroidectomy from 1991 to 2017, analyzing demographics, calcium and PTH, and localizing studies for patients with hyperplasia and single adenoma. RESULTS:549 patients underwent parathyroidectomy: 464 (85%) with adenoma, 44 (8%) with double adenoma, 38 (7%) with hyperplasia, and 3 (1%) with cancer. Compared to patients with a single adenoma, patients with hyperplasia were more likely to have negative sestamibi, ultrasound or both exams (92% vs 6%, p < 0.001; 96% vs 4%, p < 0.001; and 91% vs 2%, p < 0.001) and lower gland weights (619 ± 1067 mg vs. 1466 ± 1899 mg, p < 0.001). CONCLUSION:Parathyroid hyperplasia should be suspected in patients with lower gland weights and negative imaging.

journal_name

Am J Surg

authors

McHenry CR,Shi HH

doi

10.1016/j.amjsurg.2017.10.051

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

389-392

issue

3

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(17)31024-3

journal_volume

215

pub_type

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