Higher plasma ACTH levels in adults with Asperger syndrome.

Abstract:

OBJECTIVE:The aim of this preliminary study was to characterize the levels of plasma adrenocorticotropic hormone (ACTH) and cortisol in adult patients with Asperger syndrome (AS). METHODS:Twenty medication-free individuals with high-functioning AS were recruited from a clinic specialized in autism spectrum disorders. Ten age-matched healthy persons (hospital staff or students) with no neuropsychiatric disorders served as controls. Blood samples for the assessment were collected at 8:00 a.m. RESULTS:The patients with AS had significantly higher plasma-ACTH values than did the healthy controls. Plasma-cortisol levels were similar in both groups. CONCLUSION:Increased plasma-ACTH levels are associated with AS. Future studies are needed to clarify whether this finding is a biological consequence of chronic anxiety and elevated stress, or a sign of facilitated response to an acute novel stressor.

journal_name

J Psychosom Res

authors

Tani P,Lindberg N,Matto V,Appelberg B,Nieminen-von Wendt T,von Wendt L,Porkka-Heiskanen T

doi

10.1016/j.jpsychores.2004.12.004

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

533-6

issue

6

eissn

0022-3999

issn

1879-1360

pii

S0022-3999(05)00002-4

journal_volume

58

pub_type

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