Elevated plasma transforming growth factor-beta 1 levels in breast cancer patients decrease after surgical removal of the tumor.

Abstract:

OBJECTIVE:The authors determined whether untreated breast cancer patients have elevated plasma levels of transforming growth factor-beta 1 (TGF-beta 1). SUMMARY BACKGROUND DATA:Increased plasma TGF-beta 1 levels recently were found after chemotherapy in patients with advanced breast cancer. However, it currently is unknown whether this elevation in plasma TGF-beta 1 is caused by chemotherapy-induced normal tissue damage or whether it results from the presence of the tumor. METHODS:An enzyme-linked immunosorbent assay was used to measure plasma TGF-beta 1 levels in 26 newly diagnosed breast cancer patients before and after definitive surgery. Patients were grouped by postoperative tumor status: 1) negative lymph nodes (group 1); 2) positive lymph nodes (group 2); and 3) overt residual disease (group 3). The site of TGF-beta 1 production in the tumors was localized by immunohistochemistry and in situ hybridization. RESULTS:Plasma TGF-beta 1 levels were elevated preoperatively in 81% of the patients; TGF-beta 2 and TGF-beta 3 were undetectable. The preoperative TGF-beta 1 levels in the three patient groups were similar; however, the postoperative plasma TGF-beta 1 levels differed by disease status. The mean plasma TGF-beta 1 level in group 1 (n = 12) normalized after surgery (19.3 +/- 3.2 vs. 5.5 +/- 1.0 ng/mL, p < 0.001). In contrast, the mean plasma TGF-beta 1 levels remained above normal in both group 2 (n = 9) and group 3 (n = 5) after surgery. Transforming growth factor-beta 1 expression was found to be preferentially increased in the tumor stroma. CONCLUSIONS:Breast tumors result in increased plasma TGF-beta 1 levels in 81% of patients. After surgical removal of the primary tumor, the plasma TGF-beta 1 level normalizes in the majority of patients; persistently elevated levels correlate with the presence of lymph node metastases or overt residual tumor. These findings suggest that the usefulness of TGF-beta 1 as a potential plasma marker for breast tumors deserves further study.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Kong FM,Anscher MS,Murase T,Abbott BD,Iglehart JD,Jirtle RL

doi

10.1097/00000658-199508000-00007

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

155-62

issue

2

eissn

0003-4932

issn

1528-1140

journal_volume

222

pub_type

杂志文章
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    更新日期:1993-03-01 00:00:00

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    更新日期:2012-01-01 00:00:00

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    更新日期:1998-04-01 00:00:00

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    journal_title:Annals of surgery

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  • Adult living donor liver transplantation for patients with hepatocellular carcinoma: extending UNOS priority criteria.

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    journal_title:Annals of surgery

    pub_type: 评论,杂志文章

    doi:10.1097/01.sla.0000109022.32391.eb

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    更新日期:2004-02-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1982-12-01 00:00:00

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    pub_type: 临床试验,杂志文章

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    doi:10.1097/00000658-197505000-00036

    authors: Scott HW Jr,Shull HJ,Law DH 4th,Burko H,Page DL

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