Intestinal alkaline phosphatase prevents antibiotic-induced susceptibility to enteric pathogens.

Abstract:

OBJECTIVE:To determine the efficacy of oral supplementation of the gut enzyme intestinal alkaline phosphatase (IAP) in preventing antibiotic-associated infections from Salmonella enterica serovar Typhimurium (S. Typhimurium) and Clostridium difficile. BACKGROUND:The intestinal microbiota plays a pivotal role in human health and well-being. Antibiotics inherently cause dysbiosis, an imbalance in the number and composition of intestinal commensal bacteria, which leads to susceptibility to opportunistic bacterial infections. Previously, we have shown that IAP preserves the normal homeostasis of intestinal microbiota and that oral supplementation with calf IAP (cIAP) rapidly restores the normal gut flora. We hypothesized that oral IAP supplementation would protect against antibiotic-associated bacterial infections. METHODS:C57BL/6 mice were treated with antibiotic(s) ± cIAP in the drinking water, followed by oral gavage of S. Typhimurium or C. difficile. Mice were observed for clinical conditions and mortality. After a defined period of time, mice were killed and investigated for hematological, inflammatory, and histological changes. RESULTS:We observed that oral supplementation with cIAP during antibiotic treatment protects mice from infections with S. Typhimurium as well as with C. difficile. Animals given IAP maintained their weight, had reduced clinical severity and gut inflammation, and showed improved survival. CONCLUSIONS:Oral IAP supplementation protected mice from antibiotic-associated bacterial infections. We postulate that oral IAP supplementation could represent a novel therapy to protect against antibiotic-associated diarrhea (AAD), C. difficile-associated disease (CDAD), and other enteric infections in humans.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Alam SN,Yammine H,Moaven O,Ahmed R,Moss AK,Biswas B,Muhammad N,Biswas R,Raychowdhury A,Kaliannan K,Ghosh S,Ray M,Hamarneh SR,Barua S,Malo NS,Bhan AK,Malo MS,Hodin RA

doi

10.1097/SLA.0b013e31828fae14

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

715-22

issue

4

eissn

0003-4932

issn

1528-1140

journal_volume

259

pub_type

杂志文章
  • Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure.

    abstract:OBJECTIVE:The HepatAssist liver support system is an extracorporeal porcine hepatocyte-based bioartificial liver (BAL). The safety and efficacy of the BAL were evaluated in a prospective, randomized, controlled, multicenter trial in patients with severe acute liver failure. SUMMARY BACKGROUND DATA:In experimental anim...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1097/01.sla.0000124298.74199.e5

    authors: Demetriou AA,Brown RS Jr,Busuttil RW,Fair J,McGuire BM,Rosenthal P,Am Esch JS 2nd,Lerut J,Nyberg SL,Salizzoni M,Fagan EA,de Hemptinne B,Broelsch CE,Muraca M,Salmeron JM,Rabkin JM,Metselaar HJ,Pratt D,De La Mata M,Mc

    更新日期:2004-05-01 00:00:00

  • Prophylactic and preventive antibiotic therapy: timing, duration and economics.

    abstract::Previous studies have demonstrated that administered antibiotics must be active against major anticipated pathogens and must have reached sufficient concentrations in the tissue or body fluid at risk by the time of bacterial challenge if prophylactic therapy is to be maximally effective in reducing the infection rate ...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197906000-00004

    authors: Stone HH,Haney BB,Kolb LD,Geheber CE,Hooper CA

    更新日期:1979-06-01 00:00:00

  • Current Surgical Management of Pediatric Idiopathic Constipation: A Systematic Review of Published Studies.

    abstract:OBJECTIVE:Surgery for pediatric idiopathic constipation (IC) is undertaken after failure of bowel management programs. Decisions are influenced by rectal biopsy, transit studies, megacolon/megarectum, degree of soiling/incontinence, and anorectal manometry profile(s). A systematic review of ALL published studies critic...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0000000000001191

    authors: Siminas S,Losty PD

    更新日期:2015-12-01 00:00:00

  • The impact of perioperative risk, tumor pathology and surgical complications on disease recurrence following potentially curative resection of colorectal cancer.

    abstract:OBJECTIVE:The objective of the study was to identify determinants of disease recurrence after potentially curative resection of colorectal cancer. SUMMARY BACKGROUND DATA:The identification of patients at increased risk of disease recurrence is currently based on pathological factors. Recently, there has been consider...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31821fd469

    authors: Richards CH,Platt JJ,Anderson JH,McKee RF,Horgan PG,McMillan DC

    更新日期:2011-07-01 00:00:00

  • Pouch Versus No Pouch Following Total Gastrectomy: Meta-analysis of Randomized and Non-randomized Studies.

    abstract:OBJECTIVE:The aim of the study was to assess the impact of pouch reconstruction on perioperative outcomes, postprandial symptoms, nutritional and anthropometric parameters, and overall quality of life after total gastrectomy for gastric malignancy. SUMMARY BACKGROUND DATA:The short-term perioperative risks and longer ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,meta分析

    doi:10.1097/SLA.0000000000003082

    authors: Syn NL,Wee I,Shabbir A,Kim G,So JB

    更新日期:2019-06-01 00:00:00

  • Surgical management of intrahepatic gallstones.

    abstract::The results of surgical treatment in 100 patients with intrahepatic gallstones are reported including follow-up on 61 patients who survived more than three years. Nine patients died in the follow-up period, and of the remainder, 44 showed complete rehabilitation (72%). The results of follow-up examinations were best s...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198007000-00005

    authors: Sato T,Suzuki N,Takahashi W,Uematsu I

    更新日期:1980-07-01 00:00:00

  • The Effect of Arterial Disease Level on Outcomes of Supervised Exercise Therapy for Intermittent Claudication: A Prospective Cohort Study.

    abstract:OBJECTIVE:To assess whether level of arterial obstruction determines the effectiveness of SET in patients with IC. BACKGROUND DATA:Guidelines advocate SET before invasive treatment for IC, but early revascularization remains widespread, especially in patients with aortoiliac disease. METHODS:Patients were recruited f...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004073

    authors: van den Houten MML,Jansen S,van der Laan L,Vriens PWHE,Willigendael EM,Koelemay MJW,Scheltinga MRM,Teijink JAW,ELECT Study Group.

    更新日期:2020-07-24 00:00:00

  • Virtual reality applied to hepatic surgery simulation: the next revolution.

    abstract:OBJECTIVE:This article describes a preliminary work on virtual reality applied to liver surgery and discusses the repercussions of assisted surgical strategy and surgical simulation on tomorrow's surgery. SUMMARY BACKGROUND DATA:Liver surgery is considered difficult because of the complexity and variability of the org...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199811000-00001

    authors: Marescaux J,Clément JM,Tassetti V,Koehl C,Cotin S,Russier Y,Mutter D,Delingette H,Ayache N

    更新日期:1998-11-01 00:00:00

  • Split-liver transplantation for two adult recipients: feasibility and long-term outcomes.

    abstract:OBJECTIVE:To identify the outcomes and risks of split-liver transplantation (SLT) for two adult recipients to determine the feasibility of more widespread use of this procedure to increase the graft pool for adults. SUMMARY BACKGROUND DATA:The shortage of cadaver liver grafts for adults is increasing. Using livers fro...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200104000-00013

    authors: Azoulay D,Castaing D,Adam R,Savier E,Delvart V,Karam V,Ming BY,Dannaoui M,Krissat J,Bismuth H

    更新日期:2001-04-01 00:00:00

  • Ultrasound-guided radiofrequency-assisted segmental liver resection: a new technique.

    abstract::Segmental hepatectomy is appealing for several reasons including preservation of liver parenchyma, reduction of intraoperative blood loss, and blood replacement by dividing tissues along the anatomic planes. A simple technique guided by intraoperative ultrasound is described here using radio-frequency energy to create...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181b0c38a

    authors: Curro G,Bartolotta M,Barbera A,Jiao L,Habib N,Navarra G

    更新日期:2009-08-01 00:00:00

  • Fibrin sealant versus mechanical stapling for mesh fixation during endoscopic extraperitoneal inguinal hernioplasty: a randomized prospective trial.

    abstract:OBJECTIVE:To compare the clinical outcome of simultaneous bilateral endoscopic totally extraperitoneal inguinal hernioplasty (TEP) using fibrin sealant (FS) and mechanical stapling for prosthetic mesh fixation. SUMMARY BACKGROUND DATA:Similar efficacy of FS and mechanical stapling for mesh fixation has been demonstrat...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/01.sla.0000186440.02977.de

    authors: Lau H

    更新日期:2005-11-01 00:00:00

  • Clinicopathological aspects of high bile duct cancer. Experience with resection and bypass surgical treatments.

    abstract::This report reviews the experience of the Hepatobiliary Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London with 16 patients having proximal extrahepatic bile duct malignancy who underwent resection and a comparable group of 15 patients who had surgical bypass. The purposes of the review were to eval...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198406000-00001

    authors: Beazley RM,Hadjis N,Benjamin IS,Blumgart LH

    更新日期:1984-06-01 00:00:00

  • Cholecystokinin/Cholecystokinin-1 receptor-mediated peripheral activation of the afferent vagus by enteral nutrients attenuates inflammation in rats.

    abstract:OBJECTIVE:The current study investigates activation of the nutritional anti-inflammatory pathway by lipid-rich nutrition. BACKGROUND:Enteral nutrition activates humoral and neural pathways to regulate food intake and sustain energy balance. Recently, we demonstrated that enteral nutrition and in particular lipid-rich ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181dae411

    authors: Lubbers T,de Haan JJ,Luyer MD,Verbaeys I,Hadfoune M,Dejong CH,Buurman WA,Greve JW

    更新日期:2010-08-01 00:00:00

  • Laparoscopic liver resection for malignant liver tumors: preliminary results of a multicenter European study.

    abstract:OBJECTIVE:To assess the feasibility, safety, and outcome of laparoscopic liver resection for malignant liver tumors. SUMMARY BACKGROUND DATA:The precise role of laparoscopy in resection of liver malignancies (hepatocellular carcinoma [HCC] and liver metastases) remains controversial despite an increasing number of pub...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00000658-200207000-00014

    authors: Gigot JF,Glineur D,Santiago Azagra J,Goergen M,Ceuterick M,Morino M,Etienne J,Marescaux J,Mutter D,van Krunckelsven L,Descottes B,Valleix D,Lachachi F,Bertrand C,Mansvelt B,Hubens G,Saey JP,Schockmel R,Hepatobiliary a

    更新日期:2002-07-01 00:00:00

  • Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis.

    abstract::The etiology and mechanisms by which severe trauma or sepsis induce hepatic failure are unknown. Previously we showed that Kupffer cells (KC), the fixed macrophages of the liver, induce a profound decrease in hepatocyte (HC) total-protein synthesis when exposed to endotoxin. Furthermore we demonstrated that endotoxin-...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199010000-00009

    authors: Curran RD,Billiar TR,Stuehr DJ,Ochoa JB,Harbrecht BG,Flint SG,Simmons RL

    更新日期:1990-10-01 00:00:00

  • A prognostic nomogram for prediction of recurrence in desmoid fibromatosis.

    abstract:OBJECTIVE:To construct a postoperative nomogram to estimate the risk of local recurrence for patients with desmoid tumors. BACKGROUND:The standard management of desmoid tumors is resection, but many recur locally. Other options include observation or novel chemotherapeutics, but little guidance exists on selecting tre...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31828c8a30

    authors: Crago AM,Denton B,Salas S,Dufresne A,Mezhir JJ,Hameed M,Gonen M,Singer S,Brennan MF

    更新日期:2013-08-01 00:00:00

  • Adrenergic control of adipocyte lipolysis in trauma and sepsis.

    abstract::Adipocyte lipolysis and its adrenergic control were studied in vitro from normal patients and those with trauma and sepsis. The adrenergic receptors were studied in terms of their responsiveness, a measure of the postreceptor mechanism, and their sensitivity, a measure of the receptor number or affinity. With early tr...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198712000-00010

    authors: Forse RA,Leibel R,Askanazi J,Hirsch J,Kinney JM

    更新日期:1987-12-01 00:00:00

  • Endovascular repair of abdominal aortic aneurysms: risk stratified outcomes.

    abstract:OBJECTIVE:The impact of co-morbid conditions on early and late clinical outcomes after endovascular treatment of abdominal aortic aneurysm (AAA) was assessed in concurrent cohorts of patients stratified with respect to risk for intervention. SUMMARY BACKGROUND DATA:As a minimally invasive strategy for the treatment of...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200206000-00011

    authors: Chaikof EL,Lin PH,Brinkman WT,Dodson TF,Weiss VJ,Lumsden AB,Terramani TT,Najibi S,Bush RL,Salam AA,Smith RB 3rd

    更新日期:2002-06-01 00:00:00

  • The impact of Clostridium difficile on a surgical service: a prospective study of 374 patients.

    abstract:OBJECTIVE:To evaluate the epidemiology of Clostridium difficile colitis (CDC) in a subset of patients admitted specifically to a surgical service. SUMMARY BACKGROUND DATA:CDC is an increasingly prevalent nosocomial infection that can prolong hospitalization and adversely affect patient outcome. Although this disease h...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199802000-00021

    authors: Kent KC,Rubin MS,Wroblewski L,Hanff PA,Silen W

    更新日期:1998-02-01 00:00:00

  • Malignant fibrous histiocytoma of the pulmonary artery.

    abstract::A patient is reported whose symptoms and clinical features were interpreted as pulmonary embolism. However, the ultimate diagnosis was malignant fibrous histiocytoma of the pulmonary artery, which was made evident at operation. Although extremely rare in the early medical literature, primary sarcoma of the pulmonary a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198702000-00017

    authors: Van Damme H,Vaneerdeweg W,Schoofs E

    更新日期:1987-02-01 00:00:00

  • Minimally invasive cardiac valve surgery improves patient satisfaction while reducing costs of cardiac valve replacement and repair.

    abstract:OBJECTIVE:This study compares the quality of valve replacement and repair performed through minimally invasive incisions as compared to the standard operation for aortic and mitral valve replacement. SUMMARY BACKGROUND DATA:With the advent of minimally invasive laparoscopic approaches to orthopedic surgery, urology, g...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199710000-00003

    authors: Cohn LH,Adams DH,Couper GS,Bichell DP,Rosborough DM,Sears SP,Aranki SF

    更新日期:1997-10-01 00:00:00

  • Resting energy expenditure in controls and cancer patients with localized and diffuse disease.

    abstract::Resting energy expenditure (REE), nutritional parameters, and substrate levels were measured using a technique to minimize artifacts in 11 control patients, nine patients with localized, and four patients with diffuse neoplastic disease. Patients with diffuse disease had significantly increased percentage preillness w...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198403000-00008

    authors: Arbeit JM,Lees DE,Corsey R,Brennan MF

    更新日期:1984-03-01 00:00:00

  • Clinicopathologic factors associated with false-negative sentinel lymph-node biopsy in breast cancer.

    abstract:SUMMARY BACKGROUND DATA:Previous studies have suggested a variety of factors that may affect the false negative (FN) rate for sentinel lymph node (SLN) biopsy in breast cancer. Because FN results are relatively rare, no prior studies have had sufficient sample size to allow detailed statistical analysis of factors pred...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.sla.0000165200.32722.02

    authors: Martin RC 2nd,Chagpar A,Scoggins CR,Edwards MJ,Hagendoorn L,Stromberg AJ,McMasters KM,University of Louisville Breast Cancer Sentinel Lymph Node Study.

    更新日期:2005-06-01 00:00:00

  • Local and Visiting Physician Perspectives on Short Term Surgical Missions in Guatemala: A Qualitative Study.

    abstract:OBJECTIVE:To explore the impact of short-term surgical missions (STMs) on medical practice in Guatemala as perceived by Guatemalan and foreign physicians. SUMMARY BACKGROUND DATA:STMs send physicians from high-income countries to low and middle-income countries to address unmet surgical needs. Although participation a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003292

    authors: Coughran AJ,Merrell SB,Pineda C,Sceats LA,Yang GP,Morris AM

    更新日期:2019-04-18 00:00:00

  • Remote Ischemic Conditioning Prevents Lung and Liver Injury After Hemorrhagic Shock/Resuscitation: Potential Role of a Humoral Plasma Factor.

    abstract:OBJECTIVE:To evaluate the efficacy of remote ischemic conditioning (RIC) on organ protection after hemorrhagic shock/resuscitation (S/R) in a murine model. BACKGROUND:Ischemia/reperfusion resulting from S/R contributes to multiple organ dysfunction in trauma patients. We hypothesized that RIC before shock (remote isch...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000877

    authors: Leung CH,Caldarone CA,Wang F,Venkateswaran S,Ailenberg M,Vadasz B,Wen XY,Rotstein OD

    更新日期:2015-06-01 00:00:00

  • An Implementation Assessment of the Virtual Acute Care for Elders Program From the Perspective of Key Stakeholders.

    abstract:OBJECTIVE:The aim of this study was to obtain feedback from key stakeholders and end users to identify program strengths and weaknesses to plan for wider dissemination and implementation of the Virtual Acute Care for Elders (Virtual ACE) program, a novel intervention that improves outcomes for older surgical patients. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004433

    authors: Balentine CJ,Morris M,Knight SJ,Turan JM,Flood KL,Gutierrez-Meza D,Macdonald CL,Bhatia S,Brown CJ

    更新日期:2020-11-16 00:00:00

  • Endocrine tumors of the duodenum. Clinical characteristics and hormone content.

    abstract::Nineteen patients with primary duodenal carcinoid were analysed retrospectively, and eight of the tumors were immunocytochemically examined. One tumor contained somatostatin, two tumors gastrin, two tumors both these peptides, and one tumor contained serotonin. In two tumors no peptide or amine could be demonstrated. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198304000-00003

    authors: Lasson A,Alwmark A,Nobin A,Sundler F

    更新日期:1983-04-01 00:00:00

  • Effects of superoxide dismutase and allopurinol on the survival of acute island skin flaps.

    abstract::We have demonstrated previously that oxygen-derived free radicals are important mediators of tissue injury following ischemia (total venous occlusion) and reperfusion in small (3 cm X 6 cm) island skin flaps in rats. In this study, we evaluated extension of this concept to regional ischemia in large (8 cm X 8 cm) acut...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198503000-00018

    authors: Im MJ,Manson PN,Bulkley GB,Hoopes JE

    更新日期:1985-03-01 00:00:00

  • Single administration of thrombopoietin prevents progression of liver fibrosis and promotes liver regeneration after partial hepatectomy in cirrhotic rats.

    abstract:OBJECTIVE:To evaluate the effect of thrombopoietin on liver regeneration after hepatectomy and antifibrosis under conditions of liver cirrhosis in rats. SUMMARY BACKGROUND DATA:We revealed that platelets induced by thrombopoietin administration promote liver regeneration after hepatectomy in the normal liver. METHODS...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31818584c7

    authors: Murata S,Hashimoto I,Nakano Y,Myronovych A,Watanabe M,Ohkohchi N

    更新日期:2008-11-01 00:00:00

  • Is there still a glass ceiling for women in academic surgery?

    abstract::Despite the dramatically increased entry of women into general surgery and surgical subspecialties, traditionally male-dominated fields, there remains a gross under-representation of women in the leadership positions of these departments. Women begin their careers with fewer academic resources and tend to progress thr...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0b013e3182111120

    authors: Zhuge Y,Kaufman J,Simeone DM,Chen H,Velazquez OC

    更新日期:2011-04-01 00:00:00