Living Donor Liver Transplantation in Children: Surgical and Immunological Results in 250 Recipients at Université Catholique de Louvain.

Abstract:

OBJECTIVES:To evaluate the outcome of pediatric living donor liver transplantation (LDLT) regarding portal vein (PV) reconstruction, ABO compatibility, and impact of maternal donation on graft acceptance. BACKGROUND:LDLT and ABO-mismatched transplantation constitute feasible options to alleviate organ shortage in children. Vascular complications of portal hypoplasia in biliary atresia (BA) and acute rejection (AR) are still major concerns in this field. METHODS:Data from 250 pediatric LDLT recipients, performed at Cliniques Universitaires Saint-Luc between July 1993 and June 2012, were collected retrospectively. Results were analyzed according to ABO matching and PV complications. Uni- and multivariate analyses were performed to study the impact of immunosuppression, sex matching, and maternal donation on AR rate. RESULTS:Overall, the 10-year patient survival rate was 93.2%. Neither patient or graft loss nor vascular rejection, nor hemolysis, was encountered in the ABO nonidentical patients (n = 58), provided pretransplant levels of relevant isoagglutinins were below 1/16. In BA recipients, the rate of PV complications was lower after portoplasty (4.6%) than after truncal PV anastomosis (9.8%) and to jump graft interposition (26.9%; P = 0.027). In parental donation, maternal grafts were associated with higher 1-year AR-free survival (55.2%) than paternal grafts (39.8%; P = 0.041), but only in BA patients. CONCLUSIONS:LDLT, including ABO-mismatched transplantation, constitutes a safe and efficient therapy for liver failure in children. In BA patients with PV hypoplasia, portoplasty seems to constitute the best technique for PV reconstruction. Maternal donation might be a protective factor for AR.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Gurevich M,Guy-Viterbo V,Janssen M,Stephenne X,Smets F,Sokal E,Lefebvre C,Balligand JL,Pirotte T,Veyckemans F,Clapuyt P,Menten R,Dumitriu D,Danse E,Annet L,Clety SC,Detaille T,Latinne D,Sempoux C,Laterre PF,de Mag

doi

10.1097/SLA.0000000000001094

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

1141-9

issue

6

eissn

0003-4932

issn

1528-1140

journal_volume

262

pub_type

杂志文章
  • Red blood cell transfusion threshold in postsurgical pediatric intensive care patients: a randomized clinical trial.

    abstract:BACKGROUND:The optimal transfusion threshold after surgery in children is unknown. We analyzed the general surgery subgroup of the TRIPICU (Transfusion Requirements in Pediatric Intensive Care Units) study to determine the impact of a restrictive versus a liberal transfusion strategy on new or progressive multiple orga...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0b013e3181c5dc2e

    authors: Rouette J,Trottier H,Ducruet T,Beaunoyer M,Lacroix J,Tucci M,Canadian Critical Care Trials Group.,PALISI Network.

    更新日期:2010-03-01 00:00:00

  • Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans.

    abstract:OBJECTIVE:To determine whether ischemic preconditioning protects the human liver against a subsequent period of ischemia in patients undergoing hemihepatectomy, and to identify possible underlying protective mechanisms of ischemic preconditioning, such as inhibition of hepatocellular apoptosis. SUMMARY BACKGROUND DATA...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200008000-00001

    authors: Clavien PA,Yadav S,Sindram D,Bentley RC

    更新日期:2000-08-01 00:00:00

  • Utility of Adjuvant Chemotherapy After Neoadjuvant Chemoradiation and Esophagectomy for Esophageal Cancer.

    abstract:OBJECTIVE:To determine whether adjuvant chemotherapy (AC) after neoadjuvant chemoradiation and esophagectomy is associated with improved overall survival for patients with locally advanced esophageal cancer, and to evaluate how pathologic disease response to neoadjuvant treatment impacts this effect. BACKGROUND:Neoadj...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000001954

    authors: Burt BM,Groth SS,Sada YH,Farjah F,Cornwell L,Sugarbaker DJ,Massarweh NN

    更新日期:2017-08-01 00:00:00

  • Pigment gallstones form as a composite of bacterial microcolonies and pigment solids.

    abstract::Although previous studies have suggested that bacteria may contribute to pigment gallstone formation, the current experiments provide evidence that bacteria have a central role in this process. The studies included scanning electron microscopy (SEM) of gallstones, measurements of bacterial adherence to gallstones in v...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198709000-00002

    authors: Stewart L,Smith AL,Pellegrini CA,Motson RW,Way LW

    更新日期:1987-09-01 00:00:00

  • Prehospital intravenous fluid administration is associated with higher mortality in trauma patients: a National Trauma Data Bank analysis.

    abstract:OBJECTIVE:Prehospital intravenous (IV) fluid administration is common in trauma patients, although little evidence supports this practice. We hypothesized that trauma patients who received prehospital IV fluids have higher mortality than trauma patients who did not receive IV fluids in the prehospital setting. METHODS...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e318207c24f

    authors: Haut ER,Kalish BT,Cotton BA,Efron DT,Haider AH,Stevens KA,Kieninger AN,Cornwell EE 3rd,Chang DC

    更新日期:2011-02-01 00:00:00

  • "Sideways": results of repair of biliary injuries using a policy of side-to-side hepatico-jejunostomy.

    abstract:BACKGROUND:The Hepp-Couinaud technique describes side-to-side HJ to the main left hepatic duct but a side-to-side approach is not consistently used when repairing other ducts. Compared with end-to-side repairs, side-to-side anastomoses require less dissection, theoretically preserving blood supply to the bile ducts, an...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31819a6b2e

    authors: Winslow ER,Fialkowski EA,Linehan DC,Hawkins WG,Picus DD,Strasberg SM

    更新日期:2009-03-01 00:00:00

  • Toward strategies for cost containment in surgical patients.

    abstract::The University of Rochester, Department of Surgery, in response to an experimental community-wide limit on hospital budgets, studied high-cost general surgical patients as a potential source of leverage for containment of hospital costs. It was found that a small number of patients impact significantly on hospital cos...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198309000-00005

    authors: Drucker WR,Gavett JW,Kirshner R,Messick WJ,Ingersoll G

    更新日期:1983-09-01 00:00:00

  • Surgical management of Menetrier's disease with protein-losing gastropathy.

    abstract::Three patients with Menetrier's disease and protein-losing gastropathy who were studied during a 12 year period have been presented. The characteristic findings which differentiate them from patients with hypertrophic hypersecretory gastropathy, including the Zollinger-Ellison syndrome, are: 1) hypertrophy of gastric ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197505000-00036

    authors: Scott HW Jr,Shull HJ,Law DH 4th,Burko H,Page DL

    更新日期:1975-05-01 00:00:00

  • Endocrine tumors of the duodenum. Clinical characteristics and hormone content.

    abstract::Nineteen patients with primary duodenal carcinoid were analysed retrospectively, and eight of the tumors were immunocytochemically examined. One tumor contained somatostatin, two tumors gastrin, two tumors both these peptides, and one tumor contained serotonin. In two tumors no peptide or amine could be demonstrated. ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198304000-00003

    authors: Lasson A,Alwmark A,Nobin A,Sundler F

    更新日期:1983-04-01 00:00:00

  • Surgery for post-myocardial infarct ventricular septal defect.

    abstract::Forty-three patients (mean age 62 +/- 1 years) were treated for ventricular septal defect (VSD) secondary to myocardial infarction. Whenever possible, operation was postponed until six weeks post-onset chest pain. However, hemodynamic instability, evidenced by cardiogenic shock, refractory pulmonary edema, or a rising...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197709000-00004

    authors: Daggett WM,Guyton RA,Mundth ED,Buckley MJ,McEnany MT,Gold HK,Leinbach RC,Austen WG

    更新日期:1977-09-01 00:00:00

  • Long-term Results of a Randomized Double-blinded Prospective Trial of a Lightweight (Ultrapro) Versus a Heavyweight Mesh (Prolene) in Laparoscopic Total Extraperitoneal Inguinal Hernia Repair (TULP-trial).

    abstract:OBJECTIVE:The aim of the randomized clinical trial was to compare the 2 years of clinical outcomes of a lightweight (Ultrapro) vs a heavyweight (Prolene) mesh for laparoscopic total extraperitoneal (TEP) inguinal hernia repair. BACKGROUND:Lightweight meshes reduce postoperative pain and stiffness in open anterior ingu...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000001579

    authors: Burgmans JP,Voorbrood CE,Simmermacher RK,Schouten N,Smakman N,Clevers G,Davids PH,Verleisdonk EM,Hamaker ME,Lange JF,van Dalen T

    更新日期:2016-05-01 00:00:00

  • Reduction of Postoperative Wound Infections by Antiseptica (RECIPE)?: A Randomized Controlled Trial.

    abstract:OBJECTIVE:To evaluate whether intraoperative subcutaneous wound irrigation with 0.04% polyhexanide can reduce surgical site infection (SSI) in elective laparotomies compared to saline. BACKGROUND:SSI is a common complication after gastrointestinal surgery. To date, there is a lack of evidence whether subcutaneous woun...

    journal_title:Annals of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/SLA.0000000000003645

    authors: Strobel RM,Leonhardt M,Krochmann A,Neumann K,Speichinger F,Hartmann L,Lee LD,Beyer K,Daum S,Kreis ME,Lauscher JC

    更新日期:2020-07-01 00:00:00

  • The Use of Caffeinated Substances by Surgeons for Cognitive Enhancement.

    abstract:OBJECTIVE:To investigate the use of coffee, caffeinated drinks, and caffeine tablets for pharmacological cognitive enhancement (CE) among surgeons. BACKGROUND:Surgeons have demanding workloads, and the resulting fatigue and concentration deficits can lead to medical errors. Some surgeons use substances that promote wa...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000830

    authors: Franke AG,Bagusat C,McFarlane C,Tassone-Steiger T,Kneist W,Lieb K

    更新日期:2015-06-01 00:00:00

  • Repeat hepatectomy for colorectal liver metastases.

    abstract:OBJECTIVE:The authors assess the long-term results of repeat hepatectomies for recurrent metastases of colorectal cancer and determine the factors that can predict survival. SUMMARY BACKGROUND DATA:Safer techniques of hepatic resection have allowed surgeons to consider repeat hepatectomy for colorectal metastases in a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199701000-00006

    authors: Adam R,Bismuth H,Castaing D,Waechter F,Navarro F,Abascal A,Majno P,Engerran L

    更新日期:1997-01-01 00:00:00

  • Pancreatectomy in multiple endocrine neoplasia type 1-related gastrinomas and pancreatic endocrine neoplasias.

    abstract:OBJECTIVE:The aim of this study was to evaluate the results of pancreatic resection in pancreatic endocrine neoplasias (PENs) in patients affected by multiple endocrine neoplasia type 1 (MEN1) syndrome. BACKGROUND:Since these tumors often show an indolent course, the role of diagnostic procedures and type of surgical ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000218073.77254.62

    authors: Tonelli F,Fratini G,Nesi G,Tommasi MS,Batignani G,Falchetti A,Brandi ML

    更新日期:2006-07-01 00:00:00

  • Surgery, trauma and immune suppression. Evolving the mechanism.

    abstract::A major surgical procedure can impair the delayed hypersensitivity response. This impairment is associated with suppressor cell activity that can alter either afferent or efferent responses. Using the third party mixed leukocyte culture to define cell types involved, major immune impairment was seen with the combinati...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198304000-00010

    authors: Lundy J,Ford CM

    更新日期:1983-04-01 00:00:00

  • Experience with a modified Witzel gastrostomy without gastropexy.

    abstract::The records of 161 adult patients who underwent a modification of the Witzel gastrostomy without gastropexy at Ellis Fischel State Cancer Hospital, Columbia, Missouri, between 1977 and 1980, are reviewed in detail and form the basis of this report. Six of these patients had gastrostomies on two different occasions. Th...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198206000-00003

    authors: Johnston WD,Lopez MJ,Kraybill WG,Bricker EM

    更新日期:1982-06-01 00:00:00

  • Michelassi II Strictureplasty for Crohn's Disease: A New Side-to-Side Isoperistaltic Strictureplasty With Discontinuous Bowel Loops.

    abstract:OBJECTIVE:We report on a new side-to-side isoperistaltic strictureplasty (SSIS), the Michelassi II or end-to-side-to-side-to-end strictureplasty, performed with discontinuous bowel loops. SUMMARY BACKGROUND DATA:The SSIS Michelassi strictureplasty was described a quarter of a century ago to avoid massive bowel resecti...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003430

    authors: Mege D,Michelassi F

    更新日期:2020-01-01 00:00:00

  • Long-term Quality of Life in Neonatal Surgical Disease.

    abstract:OBJECTIVE:This prospective observational study was designed to assess Pediatric Quality of Life (PedsQL) after surgical treatment for congenital diaphragmatic hernia (CDH), esophageal atresia/tracheoesophageal fistula (EA/TEF), Hirschsprung disease (HD), gastroschisis (GAS), omphalocele (OMP), and necrotizing enterocol...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000002918

    authors: Amin R,Knezevich M,Lingongo M,Szabo A,Yin Z,Oldham KT,Calkins CM,Sato TT,Arca MJ

    更新日期:2018-09-01 00:00:00

  • Percutaneous transluminal angioplasty as an adjunct to the surgical management of peripheral vascular disease.

    abstract::Percutaneous transluminal angioplasty (PTA) was performed as an adjunct to an operation in 43 patients with peripheral arterial insufficiency. This represents 26% of patients undergoing PTA over the past 44 months. In 23 patients PTA was done in conjunction with planned vascular reconstruction. It was successful in al...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198206000-00016

    authors: Kadir S,Smith GW,White RI Jr,Kaufman SL,Barth KH,Williams GM,O'Mara CS,Burdick JF

    更新日期:1982-06-01 00:00:00

  • Impact of a clinical pathway for elective infrarenal aortic reconstructions.

    abstract:OBJECTIVE:To determine the impact of a clinical pathway for elective infrarenal aortic reconstruction on outcome, resource utilization, and cost in a university medical center. SUMMARY BACKGROUND DATA:Clinical pathways have been reported to control costs, reduce resource utilization, and maintain or improve the qualit...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199805000-00009

    authors: Huber TS,Carlton LM,Harward TR,Russin MM,Phillips PT,Nalli BJ,Flynn TC,Seeger JM

    更新日期:1998-05-01 00:00:00

  • Demography of penetrating cardiac trauma.

    abstract::All cases of penetrating cardiac trauma in 1985 and 1986 in Jefferson County, Alabama, where patients dying of penetrating trauma received autopsies, were retrospectively reviewed. All hospitals in the county plus the single coroner's office provided the records of the 72 patients comprising this study. Incidents occu...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198906000-00004

    authors: Naughton MJ,Brissie RM,Bessey PQ,McEachern MM,Donald JM Jr,Laws HL

    更新日期:1989-06-01 00:00:00

  • Analysis of the First 217 Appendectomies of the German NOTES Registry.

    abstract:OBJECTIVE:To analyze the feasibility and safety of Natural Orifice Transluminal Endoscopic Surgery (NOTES) appendectomy, and to analyze separately the transvaginal appendectomy (TVAE) and the transgastric appendectomy (TGAE) procedures. BACKGROUND:Laparoscopic appendectomy has rare but relevant complications, namely i...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000001742

    authors: Bulian DR,Kaehler G,Magdeburg R,Butters M,Burghardt J,Albrecht R,Bernhardt J,Heiss MM,Buhr HJ,Lehmann KS

    更新日期:2017-03-01 00:00:00

  • Endorectal ileoanal anastomosis with isoperistaltic ileal reservoir after colectomy and mucosal proctectomy.

    abstract::Forty-nine patients with chronic ulcerative colitis refractory to medical therapy and four with multiple polyposis have undergone total colectomy, mucosal protectomy, and endorectal ileal pull-through with ileoanal anastomosis at the UCLA Medical Center during the past 12 years (mean age, 19.4 years). Thirty-eight pat...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198402000-00003

    authors: Fonkalsrud EW

    更新日期:1984-02-01 00:00:00

  • Lead poisoning from retained missiles. An experimental study.

    abstract::The problem of lead poisoning from bullets has been investigated by surgically implanting discs of lead, each enriched in a different natural isotope, into the tissue of two mongrel dogs and monitoring by mass spectrometry the release of the lead into each animal's blood over the course of 3 years. Lead placed in the ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198611000-00014

    authors: Manton WI,Thal ER

    更新日期:1986-11-01 00:00:00

  • Biostatistical basis of elective node dissection for malignant melanoma.

    abstract::During the years 1954 through 1964, 259 individuals with primary malignant melanoma had an elective node dissection. Microscopic metastases were found in 15% of these patients. The presence of only a microscopic focus of involvement gave a 10-year cure rate of 67%; metastasis larger than a microscopic focus in a singl...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197707000-00014

    authors: Fortner JG,Woodruff J,Schottenfeld D,Maclean B

    更新日期:1977-07-01 00:00:00

  • Training future surgical scientists: realities and recommendations.

    abstract:OBJECTIVE:To examine factors influencing surgical research and assess the current state of training future surgical scientists. SUMMARY BACKGROUND DATA:The number of surgeons actively engaged in research seems to be decreasing. Training future surgical scientists to increase these numbers depends on a variety of facto...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0b013e318163d27d

    authors: Suliburk JW,Kao LS,Kozar RA,Mercer DW

    更新日期:2008-05-01 00:00:00

  • Management of secondary peritonitis.

    abstract:OBJECTIVE:The authors review current definition, classification, scoring, microbiology, inflammatory response, and goals of management of secondary peritonitis. SUMMARY BACKGROUND DATA:Despite improved diagnostic modalities, potent antibiotics, modern intensive care, and aggressive surgical treatment, up to one third ...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/00000658-199607000-00003

    authors: Wittmann DH,Schein M,Condon RE

    更新日期:1996-07-01 00:00:00

  • Lack of preoperative enteral nutrition reduces gut-associated lymphoid cell numbers in colon cancer patients: a possible mechanism underlying increased postoperative infectious complications during parenteral nutrition.

    abstract:OBJECTIVE:To examine preoperative dietary influences on gut-associated lymphoid tissue (GALT) cell number in the context of postoperative infectious complications. BACKGROUND:There is little clinical evidence regarding whether nutritional routes affect GALT size and/or phenotype. The influence of GALT atrophy on clini...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31827a0e05

    authors: Okamoto K,Fukatsu K,Hashiguchi Y,Ueno H,Shinto E,Moriya T,Saitoh D,Yamamoto J,Hase K

    更新日期:2013-12-01 00:00:00

  • Vasodilator prostaglandins (PG) prevent renal damage after ischemia.

    abstract::Thromboxane (Tx) synthase but not cyclo-oxygenase inhibitors prevent acute tubular necrosis (ATN) after renal ischemia, a phenomenon believed to be due to stimulation of the endogenous production of vasodilating prostaglandins (PG). This study directly tests that vasodilating PG protect against the consequences of ren...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198702000-00015

    authors: Kaufman RP Jr,Anner H,Kobzik L,Valeri CR,Shepro D,Hechtman HB

    更新日期:1987-02-01 00:00:00