Serum tetranectin in patients with acute pelvic inflammatory disease (PID). Correlation to clinical and laboratory findings.

Abstract:

AIM OF STUDY:To clarify the impact of the presence of pelvic inflammatory disease (PID) and activation of the acute phase response on the serum level of tetranectin (Se-TN), a potential new tumor marker for ovarian cancer. MATERIALS AND METHODS:The study group consisted of 70 patients with a laparoscopically verified PID and 47 healthy female controls. RESULTS:Lower Se-TN levels were found for the PID group compared to the control group (p < 0.0001). It was not possible to relate the decreases in Se-TN levels to any distinct bacterial strain. Neither was it possible to find any correlation between Se-TN and severity of PID (p = 0.5). A significant positive correlation was found between Se-TN and ALB (p < 0.001). A just significant negative correlation was found between Se-TN and C-reactive protein (CRP) (p = 0.04), while no correlation was found with any of the other acute phase reactants. Highly significant correlations were found between all the acute phase reactants and grade of PID. CONCLUSIONS:A slight, but significant reduction in Se-TN was found in PID patients. The decrease was minor compared to the reported findings of very low Se-TN levels for ovarian cancer patients. However, the finding is important in the assessment of TN used as a potential screening marker for ovarian cancer, or as a diagnostic tool for pelvic tumors. Furthermore, Se-TN does not seem to behave as a negative acute phase reactant.

authors

Høgdall CK,Christiansen M,Brihmer C

doi

10.3109/00016349509008939

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

203-7

issue

3

eissn

0001-6349

issn

1600-0412

journal_volume

74

pub_type

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