Evidence for a selective inhibitory effect of thrombin on megakaryocyte progenitor growth mediated by the thrombin receptor.

abstract：:The routine methods for estimating erythrocyte size (volume and surface area) are not generally unbiased. Using geometric models introduces a bias determined by the ways in which real red blood corpuscles depart in size and shape from the simplistic ideal. Employing haematocrit and red corpuscle count to estimate mean...

journal_title：British journal of haematology

authors： Mayhew TM,Mwamengele GL,Self TJ,Travers JP

更新日期：1994-02-01 00:00:00

abstract：:Inhibitors of heat-shockprotein 90 (Hsp90) have been proposed as a novel therapeutic option for Chronic Lymphocytic Leukaemia (CLL), particularly as their mechanism of action appears independent of mutations of ATM or TP53. We investigated the activity of a novel Hsp90 inhibitor, SNX7081, against a panel of eight haem...

journal_title：British journal of haematology

authors： Best OG,Singh N,Forsyth C,Mulligan SP

更新日期：2010-10-01 00:00:00

abstract：:Primary long-term bone marrow cultures grown in 40 mM HEPES-buffered McCoy's 5A medium produced granulocyte-macrophage colony-forming units (CFU-GM) for a median of 9 weeks compared with 7 weeks with CO2/bicarbonate-buffered cultures. Reducing the medium glucose concentration (from 12.5 to 2.75 mM) extended the cultur...

journal_title：British journal of haematology

authors： Tennant GB,Truran LN,Bailey-Wood R,Burnett AK

更新日期：2000-06-01 00:00:00

abstract：:We tested whether parvovirus B19 (PVB19) is involved in benign lymph node swelling as a causative agent. The serum specimens from 13 patients with lymph node swelling of unidentified cause were tested for IgM and IgG antibody against PVB19 by Western blot analysis. Five patients had IgM antibody, and PVB19 DNA was det...

journal_title：British journal of haematology

authors： Tsuda H,Maeda Y,Nakagawa K

更新日期：1993-11-01 00:00:00

abstract：:A panel of 51 cases of essential thrombocythaemia (ET), in chronic or leukaemic phase, was investigated for p53 gene and RAS oncogenes mutations by PCR-SSCP-direct sequencing. No RAS oncogenes mutations were detected, but p53 mutations were identified in three cases: 1/27 cases (approximately 4%) in chronic phase not ...

journal_title：British journal of haematology

authors： Neri A,Fracchiolla NS,Radaelli F,Boletini A,Ribera S,Migliorini C,Trecca D,Maiolo AT

更新日期：1996-06-01 00:00:00

abstract：:The role of factor XI (FXI) in blood coagulation has been clarified in recent years by descriptions of FXI-deficient patients who are prone to excessive bleeding after haemostatic challenge. We have studied a large kindred of an Italian FXI-deficient patient with a previously undescribed mutation. The propositus, a 68...

journal_title：British journal of haematology

authors： Alhaq A,Mitchell M,Sethi M,Rahman S,Flynn G,Boulton P,Caeno G,Smith M,Savidge G

更新日期：1999-01-01 00:00:00

abstract：:The spleen acts as a blood filter and lymphopoietic organ. Asplenic and hyposplenic individuals are more susceptible to serious infections caused by encapsulated bacteria but they can be protected by antibiotic prophylaxis and immunizations. Recent progress in vaccinology means prophylaxis is now successful in the vas...

journal_title：British journal of haematology

authors： Kuchar E,Miśkiewicz K,Karlikowska M

更新日期：2015-12-01 00:00:00

abstract：:We report on a case of pyridoxine refractory hereditary sideroblastic anaemia (HSA) in a 19-year-old man who underwent peripheral blood stem cell transplantation (PBSCT) from his HLA-identical brother. By using short tandem repeat polymorphism, 100% donor cells were observed in peripheral blood on day +21; bone marrow...

journal_title：British journal of haematology

authors： González MI,Caballero D,Vázquez L,Cañizo C,Hernández R,López C,Izarra A,Arroyo JL,González M,García R,San Miguel JF

更新日期：2000-06-01 00:00:00

abstract：:Platelet function was evaluated in eight patients with chronic granulocytic leukaemia (CGL), seven Ph1 positive and one Ph1 negative. Seven of the eight patients' platelets had an absence of the second wave of adrenaline induced aggregation on at least one occasion, while five had impaired collagen aggregation. The pl...

journal_title：British journal of haematology

authors： Gerrard JM,Stoddard SF,Shapiro RS,Coccia PF,Ramsay NK,Nesbit ME,Rao GH,Krivit W,White JG

更新日期：1978-12-01 00:00:00

abstract：:This study systematically reviewed and meta-analysed the prognostic value of complete remission status at end-of-treatment (18) F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) in diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine and pred...

journal_title：British journal of haematology

authors： Adams HJ,Nievelstein RA,Kwee TC

更新日期：2015-07-01 00:00:00

abstract：:We studied MDS-associated inhibitory activity, which inhibited colony formation in vitro of granulocyte-macrophage progenitors (CFU-GM). Macrophages obtained from MDS bone marrow mononuclear cells (BM-MNC) when pretreated with granulocyte-macrophage colony stimulating factor (GM-CSF) suppressed the growth of normal CF...

journal_title：British journal of haematology

authors： Ohmori M,Ohmori S,Ueda Y,Tohyama K,Yoshida Y,Uchino H

更新日期：1990-02-01 00:00:00

abstract：:We have investigated the control of lysozyme gene expression in HL-60 cells induced to differentiate into macrophage-like cells with phorbol myristate acetate (PMA). Differentiation, as evidenced by cellular adherence, and morphological changes corresponded temporally to an increase in nonspecific esterase activity. T...

journal_title：British journal of haematology

authors： Polansky DA,Yang A,Brader K,Miller DM

更新日期：1985-05-01 00:00:00

abstract：:Primary systemic amyloidosis (AL) is a plasma cell disorder characterized by deposition of monoclonal light chains in different organ systems. Although multiple and complex numerical chromosomal abnormalities have been described in patients with multiple myeloma, it is currently unknown whether such changes occur in s...

journal_title：British journal of haematology

authors： Fonseca R,Ahmann GJ,Jalal SM,Dewald GW,Larson DR,Therneau TM,Gertz MA,Kyle RA,Greipp PR

更新日期：1998-12-01 00:00:00

abstract：:Approximately 31 patients with chronic myelogenous leukaemia (CML) are documented in the literature who survived more than 10 years after diagnosis. We present a CML-patient whose survival of 27 years is probably the longest reported so far. The analysis of the course of disease in these patients revealed that the dur...

journal_title：British journal of haematology

authors： Prischl FC,Haas OA,Lion T,Eyb R,Schwarzmeier JD

更新日期：1989-03-01 00:00:00

abstract：:The organelle pathology of neutrophils in chronic granulocytic leukaemia (CGL) was investigated by analytical subcellular fractionation. There were minor reductions in activity of some granule enzymes with an abnormal distribution in sucrose density gradients of the specific granules. There was a marked reduction of 5...

journal_title：British journal of haematology

authors： Rustin GJ,Peters TJ

更新日期：1979-04-01 00:00:00

abstract：:In a 61-year-old man with glucose-6-phosphate dehydrogenase (G6PD) deficiency and poorly controlled non-insulin-dependent diabetes mellitus, an episode of acute haemolysis occurred after the administration of glyburide (glibenclamide). Erythrocyte fragmentation, with haemoglobin condensation zones next to clear zones,...

journal_title：British journal of haematology

authors： Meloni G,Meloni T

更新日期：1996-01-01 00:00:00

abstract：:We report a case of persistent infection with human parvovirus B19 (PVB19), manifesting clinically as recurrent agranulocytosis and in bone marrow biopsy as recurrent pure granulocytic aplasia. Persistence of parvovirus infection was documented by the presence of PVB19 DNA and anti-PVB19-IgM antibodies in the serum fo...

journal_title：British journal of haematology

authors： Pont J,Puchhammer-Stöckl E,Chott A,Popow-Kraupp T,Kienzer H,Postner G,Honetz N

更新日期：1992-02-01 00:00:00

abstract：:Recent studies concerning the numbers of circulating clonal B cells in patients with multiple myeloma (MM) have reported conflicting data regarding the exact levels of clonal B cells and the existence of clonal cells in the CD34 compartment. In this report we show that high numbers of clonal cells with a phenotype of ...

journal_title：British journal of haematology

authors： Rasmussen T,Kastrup J,Knudsen LM,Johnsen HE

更新日期：1999-04-01 00:00:00

abstract：:Analysis of complementary RNA molecules of junctional regions of rearranged T-cell-receptor-gamma genes show a pattern of conformational polymorphisms which is specific for an individual lymphocytic clone. In a blinded study we analysed formalin-fixed, paraffin-embedded histological specimens from gastrointestinal lym...

journal_title：British journal of haematology

authors： Koch OM,Probst M,Tiemann M,Jakob I,Volkenandt M,Wienecke R,Buer J,Atzpodien J,Lenz HJ,Danenberg PV

更新日期：1994-02-01 00:00:00

abstract：:Imatinib mesylate is useful for facilitating allogeneic stem cell transplantation (allo-SCT) in advanced-phase chronic myelogenous leukaemia (AP-CML) patients. However, although the side-effects of imatinib are usually minor, cardiac morbidity can develop as a latent adverse effect post SCT when a myeloablative SCT is...

journal_title：British journal of haematology

authors： Sohn SK,Kim JG,Kim DH,Lee KB

更新日期：2003-05-01 00:00:00

abstract：:Apoptosis is involved in many biological processes, especially during chemotherapy in cancer patients. Chemotherapy is also associated with an increased risk of thrombosis. The relationship between thrombogenicity and apoptosis was studied in various human tumour cell lines and non-tumour cell lines. Apoptosis was ind...

journal_title：British journal of haematology

authors： Wang J,Weiss I,Svoboda K,Kwaan HC

更新日期：2001-11-01 00:00:00

abstract：:Erythroid colonies derived from the circulating early erythroid precursor (BFU-E) of a patient with congenital dyserythropoietic anaemia type I (CDA I) have been grown in plasma clot and studied by electron microscopy. The number of circulating BFU-E was in the normal range with a roughly normal appearance at the ligh...

journal_title：British journal of haematology

authors： Vainchenker W,Guichard J,Bouguet J,Breton-Gorius J

更新日期：1980-09-01 00:00:00

abstract：:The influence of erythrocyte shape changes on the sedimentation rate was studied in vitro and in vivo. In vitro the highest sedimentation rate was observed with a slight degree of stomatocytosis (morphological index-0.3; i.e. one red cell out of three being a stomatocyte I). With increasing degrees of stomatocytosis t...

journal_title：British journal of haematology

authors： Reinhart WH,Singh A,Straub PW

更新日期：1989-12-01 00:00:00

abstract：:Association between HLA haplotypes and long survival was investigated in 116 children with acute lymphoblastic leukaemia. It was found that patients with A2 B12 and/or A2 B40 haplotypes survived longer than patients wtihout these two haplotypes. Since all children were treated with transfer factor obtained from their ...

journal_title：British journal of haematology

authors： De Bruyère M,Cornu G,Heremans-Bracke T,Malchaire J,Sokal G

更新日期：1980-02-01 00:00:00

abstract：:Mantle cell lymphoma (MCL), a malignancy of B-lymphocytes, has a poor prognosis. It is thus necessary to improve the understanding of the pathobiology of MCL and identify factors contributing to its aggressiveness. Our studies, based on Affymetrix data from 17 MCL biopsies, real-time quantitative polymerase chain reac...

journal_title：British journal of haematology

authors： Mundt F,Merrien M,Nygren L,Sutton LA,Christensson B,Wahlin BE,Rosenquist R,Sander B,Wasik AM

更新日期：2019-05-01 00:00:00

abstract：:The proteasome inhibitor, bortezomib, potentially increases cell sensitivity to chemotherapy. This study was performed to determine the overall response rate (ORR), overall survival (OS), progression-free survival (PFS) and toxicity of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) compared to CHOP...

journal_title：British journal of haematology

authors： Furtado M,Johnson R,Kruger A,Turner D,Rule S

更新日期：2015-01-01 00:00:00

abstract：:Alternative donor bone marrow transplantation (BMT) to treat severe aplastic anaemia (SAA) in children and young adults has been complicated by high rates of graft rejection and severe graft-versus-host disease (GVHD). We hypothesized that increased immunosuppression combined with T-cell depletion of the marrow graft ...

journal_title：British journal of haematology

authors： Margolis D,Camitta B,Pietryga D,Keever-Taylor C,Baxter-Lowe LA,Pierce K,Kupst MJ,French J 3rd,Truitt R,Lawton C,Murray K,Garbrecht F,Flomenberg N,Casper J

更新日期：1996-07-01 00:00:00

abstract：:We examined the role of the ligand for c-mpl. thrombopoietin (TPO). in murine early haemopoiesis. using a serum-free culture system. TPO in combination with the ligand for c-kit (SF) or interleukin-3 (IL-3) supported colony formation by marrow cells of 5-fluorouracil (5-FU)-treated mice whereas TPO alone yielded no co...

journal_title：British journal of haematology

authors： Itoh R,Katayama N,Kato T,Mahmud N,Masuya M,Ohishi K,Minami N,Miyazaki H,Shiku H

更新日期：1996-08-01 00:00:00

abstract：:The clinical significance of Aspergillus fungaemia in the setting of a deep-seated aspergillosis has not been clearly established. Among 107 microbiologically documented Aspergillus infections in patients with haematological diseases observed over a 17-year period, blood cultures grew Aspergillus species from 10 cases...

journal_title：British journal of haematology

authors： Girmenia C,Nucci M,Martino P

更新日期：2001-07-01 00:00:00

abstract：:Bone mineral content (BMC) of the radius was measured using single photon absorptiometry (SPA) in nine children with congenital neutropenia. Five had normal values. Two children with severe congenital neutropenia (SCN) had low BMC, and two boys with Schwachman syndrome had biochemistry suggestive of rickets. ...

journal_title：British journal of haematology

authors： Fewtrell MS,Kinsey SE,Williams DM,Bishop NJ

更新日期：1997-06-01 00:00:00