Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.

abstract：:NMYC is a gene whose amplification and overexpression have been implicated in the generation of certain human malignancies. Little is known of how the expression of NMYC is normally controlled. We have therefore characterized transcription from the gene and the structure and stability of the resulting mRNAs. Transcrip...

journal_title：Molecular and cellular biology

authors： Stanton LW,Bishop JM

更新日期：1987-12-01 00:00:00

abstract：:In the cell cycle of the budding yeast Saccharomyces cerevisiae, expression of the histone genes H2A and H2B of the TRT1 and TRT2 loci is regulated by the performance of "start," the step that also regulates the cell cycle. Here we show that histone production is also subject to an additional form of regulation that i...

journal_title：Molecular and cellular biology

authors： Drebot MA,Veinot-Drebot LM,Singer RA,Johnston GC

更新日期：1990-12-01 00:00:00

abstract：:The selenoenzyme phospholipid hydroperoxide glutathione peroxidase (PHGPx) is regarded as the major molecular target of selenodeficiency in rodents, accounting for most of the histopathological and structural abnormalities of testicular tissue and male germ cells. PHGPx exists as a cytosolic form, mitochondrial form, ...

journal_title：Molecular and cellular biology

authors： Conrad M,Moreno SG,Sinowatz F,Ursini F,Kölle S,Roveri A,Brielmeier M,Wurst W,Maiorino M,Bornkamm GW

更新日期：2005-09-01 00:00:00

abstract：:The turnover of the colony-stimulating factor 1 receptor (CSF-1R), the c-fms proto-oncogene product, is accelerated by ligand binding or by activators of protein kinase C (PKC), such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). The mechanisms of ligand- and TPA-induced downmodulation were shown to ...

journal_title：Molecular and cellular biology

authors： Downing JR,Roussel MF,Sherr CJ

更新日期：1989-07-01 00:00:00

abstract：:In this report, we document an unusual mode of tissue-enriched gene expression that is primarily mediated by alternative and inefficient splicing. We have analyzed posttranscriptional regulation of the Drosophila erect wing gene, which provides a vital neuronal function and is essential for the formation of certain mu...

journal_title：Molecular and cellular biology

authors： Koushika SP,Soller M,DeSimone SM,Daub DM,White K

更新日期：1999-06-01 00:00:00

abstract：:Transfection of C3H/10T1/2 cells with a c-myc gene resulted in the acquisition of responsiveness to transforming growth factor type beta. Cells transfected with an activated H-ras gene or an H-ras and c-myc gene, however, exhibited a transformed morphology and spontaneous soft-agar growth, a phenotype induced reversib...

journal_title：Molecular and cellular biology

authors： Leof EB,Proper JA,Moses HL

更新日期：1987-07-01 00:00:00

abstract：:Sophisticated models for the regulation of mitotic entry are lacking for human cells. Inactivating human cyclin A/Cdk2 complexes through diverse approaches delays mitotic entry and promotes inhibitory phosphorylation of Cdk1 on tyrosine 15, a modification performed by Wee1. We show here that cyclin A/Cdk2 complexes ph...

journal_title：Molecular and cellular biology

authors： Li C,Andrake M,Dunbrack R,Enders GH

更新日期：2010-01-01 00:00:00

abstract：:We have characterized a cDNA encoding a cysteine-rich, acidic integral membrane protein (CRAM) of the parasitic protozoa Trypanosoma brucei and Trypanosoma equiperdum. Unlike other membrane proteins of T. brucei, which are distributed throughout the cell surface, CRAM is concentrated in the flagellar pocket, an invagi...

journal_title：Molecular and cellular biology

authors： Lee MG,Bihain BE,Russell DG,Deckelbaum RJ,Van der Ploeg LH

更新日期：1990-09-01 00:00:00

abstract：:RNase H1 in mammalian cells is present in nuclei and mitochondria. Its absence in mitochondria results in embryonic lethality due to the failure to amplify mitochondrial DNA (mtDNA). Dual localization to mitochondria and nuclei results from differential translation initiation at two in-frame AUGs (M1 and M27) of a sin...

journal_title：Molecular and cellular biology

authors： Suzuki Y,Holmes JB,Cerritelli SM,Sakhuja K,Minczuk M,Holt IJ,Crouch RJ

更新日期：2010-11-01 00:00:00

abstract：:Mouse mammary tumor virus (MMTV) has long been implicated in mouse mammary carcinogenesis, and it is now well established that the long terminal repeat (LTR) contains regulatory sequences responsible for glucocorticoid-mediated induction of viral RNA. However, we have demonstrated previously that androgens as well as ...

journal_title：Molecular and cellular biology

authors： Darbre P,Page M,King RJ

更新日期：1986-08-01 00:00:00

abstract：:The Saccharomyces cerevisiae pheromone a-factor is produced by a cells and interacts with alpha cells to cause cell cycle arrest and other physiological responses associated with mating. Two a-factor structural genes, MFA1 and MFA2, have been previously cloned with synthetic probes based on the a-factor amino acid seq...

journal_title：Molecular and cellular biology

authors： Michaelis S,Herskowitz I

更新日期：1988-03-01 00:00:00

abstract：:The human T-cell leukemia virus-encoded oncoprotein Tax is a potent activator of viral transcription. Tax function is strictly dependent upon the cellular transcription factor CREB, and together they bind cAMP response elements within the viral promoter and mediate high-level viral transcription. Signal-dependent CREB...

journal_title：Molecular and cellular biology

authors： Geiger TR,Sharma N,Kim YM,Nyborg JK

更新日期：2008-02-01 00:00:00

abstract：:Akt is activated on the plasma membrane and its substrates are distributed throughout various cellular compartments. To phosphorylate its substrates, Akt needs to be recruited to specific intracellular compartments. Thus, regulation of Akt cellular compartmentalization constitutes an important mechanism to specify Akt...

journal_title：Molecular and cellular biology

authors： Ding J,Du K

更新日期：2009-03-01 00:00:00

abstract：:TFIIIC plays a key role in nucleating the assembly of the initiation factor TFIIIB on class III genes. We have characterized an essential gene, TFC8, encoding the 60-kDa polypeptide, tau60, present in affinity-purified TFIIIC. Hemagglutinin-tagged variants of tau60 were found to be part of TFIIIC-tDNA complexes and to...

journal_title：Molecular and cellular biology

authors： Deprez E,Arrebola R,Conesa C,Sentenac A

更新日期：1999-12-01 00:00:00

abstract：:The p20K gene is induced in conditions of reversible growth arrest in chicken embryo fibroblasts (CEF). This expression is dependent on transcriptional activation and on a region of the promoter designated the quiescence-responsive unit (QRU). In this report, we describe the regulatory elements of the QRU responsible ...

journal_title：Molecular and cellular biology

authors： Kim S,Mao PL,Gagliardi M,Bédard PA

更新日期：1999-08-01 00:00:00

abstract：:In eukaryotic cells, cohesion between sister chromatids allows chromosomes to biorient on the metaphase plate and holds them together until they separate into daughter cells during mitosis. Cohesion is mediated by the cohesin protein complex. Although the association of this complex with particular regions of the geno...

journal_title：Molecular and cellular biology

authors： Bausch C,Noone S,Henry JM,Gaudenz K,Sanderson B,Seidel C,Gerton JL

更新日期：2007-12-01 00:00:00

abstract：:Extinction of phosphoenolpyruvate carboxykinase (PCK) gene expression in hepatoma x fibroblast hybrids is mediated by a trans-acting genetic locus designated tissue-specific extinguisher 1 (TSE1). To identify PCK gene sequences required for extinction, hepatoma transfectants expressing PCK-thymidine kinase (TK) chimer...

journal_title：Molecular and cellular biology

authors： Thayer MJ,Lugo TG,Leach RJ,Fournier RE

更新日期：1990-06-01 00:00:00

abstract：:Different models have been proposed explaining how eukaryotic gene transcription is terminated. Recently, Nsi1, a factor involved in silencing of ribosomal DNA (rDNA), was shown to be required for efficient termination of rDNA transcription by RNA polymerase I (Pol I) in the yeast Saccharomyces cerevisiae. Nsi1 contai...

journal_title：Molecular and cellular biology

authors： Merkl P,Perez-Fernandez J,Pilsl M,Reiter A,Williams L,Gerber J,Böhm M,Deutzmann R,Griesenbeck J,Milkereit P,Tschochner H

更新日期：2014-10-01 00:00:00

abstract：:Telomerase extends chromosome ends by the synthesis of tandem simple-sequence repeats. Studies of minimal recombinant telomerase ribonucleoprotein (RNP) reconstituted in vitro have revealed sequences within the telomerase RNA subunit (TER) that are required to establish its internal template and other unique features ...

journal_title：Molecular and cellular biology

authors： Cunningham DD,Collins K

更新日期：2005-06-01 00:00:00

abstract：:Glucose and oxygen are two of the most important molecules transferred from mother to fetus during eutherian pregnancy, and the metabolic fates of these nutrients converge at the transport and metabolism of pyruvate in mitochondria. Pyruvate enters the mitochondrial matrix through the mitochondrial pyruvate carrier (M...

journal_title：Molecular and cellular biology

authors： Bowman CE,Zhao L,Hartung T,Wolfgang MJ

更新日期：2016-07-14 00:00:00

abstract：:The G2-to-M transition (or prophase) checkpoint of the cell cycle is a critical regulator of mitotic entry. SIRT2, a tumor suppressor gene, contributes to the control of this checkpoint by blocking mitotic entry under cellular stress. However, the mechanism underlying both SIRT2 activation and regulation of the G2-to-...

journal_title：Molecular and cellular biology

authors： Movahedi Naini S,Sheridan AM,Force T,Shah JV,Bonventre JV

更新日期：2015-11-01 00:00:00

abstract：:Determining the functions of novel genes implicated in cell survival is directly relevant to our understanding of mammalian development and carcinogenesis. ARS2 is an evolutionarily conserved gene that confers arsenite resistance on arsenite-sensitive Chinese hamster ovary cells. Little is known regarding the function...

journal_title：Molecular and cellular biology

authors： Wilson MD,Wang D,Wagner R,Breyssens H,Gertsenstein M,Lobe C,Lu X,Nagy A,Burke RD,Koop BF,Howard PL

更新日期：2008-03-01 00:00:00

abstract：:The E2F transcription factors are key downstream targets of the retinoblastoma protein (pRB) tumor suppressor. We have previously shown that E2F3 plays a critical role in mediating the mitogen-induced activation of E2F-responsive genes and contributes to both the inappropriate proliferation and the p53-dependent apopt...

journal_title：Molecular and cellular biology

authors： Ziebold U,Lee EY,Bronson RT,Lees JA

更新日期：2003-09-01 00:00:00

abstract：:The PKC1 gene of Saccharomyces cerevisiae encodes a homolog of mammalian protein kinase C that is required for normal growth and division of yeast cells. We report here the isolation of the yeast MKK1 and MKK2 (for mitogen-activated protein [MAP] kinase-kinase) genes which, when overexpressed, suppress the cell lysis ...

journal_title：Molecular and cellular biology

authors： Irie K,Takase M,Lee KS,Levin DE,Araki H,Matsumoto K,Oshima Y

更新日期：1993-05-01 00:00:00

abstract：:Ure2p of Saccharomyces cerevisiae normally functions in blocking utilization of a poor nitrogen source when a good nitrogen source is available. The non-Mendelian genetic element [URE3] is a prion (infectious protein) form of Ure2p, so that overexpression of Ure2p induces the de novo appearance of infectious [URE3]. E...

journal_title：Molecular and cellular biology

authors： Maddelein ML,Wickner RB

更新日期：1999-06-01 00:00:00

abstract：:Previous studies demonstrated that growth in DBA/2 mice of MDW4, a wheat germ agglutinin-resistant (WGAr) mutant of the highly metastatic MDAY-D2 DBA/2 mouse tumor, led to the emergence of WGA-sensitive (WGAs) revertants having higher ploidy levels at the site of inoculation as well as at distant visceral metastases. ...

journal_title：Molecular and cellular biology

authors： Kerbel RS,Lagarde AE,Dennis JW,Donaghue TP

更新日期：1983-04-01 00:00:00

abstract：:Phosphorylation is one of the key mechanisms that regulate centrosome biogenesis, spindle assembly, and cell cycle progression. However, little is known about centrosome-specific phosphorylation sites and their functional relevance. Here, we identified phosphoproteins of intact Drosophila melanogaster centrosomes and ...

journal_title：Molecular and cellular biology

authors： Habermann K,Mirgorodskaya E,Gobom J,Lehmann V,Müller H,Blümlein K,Deery MJ,Czogiel I,Erdmann C,Ralser M,von Kries JP,Lange BM

更新日期：2012-09-01 00:00:00

abstract：:The Rel family of transcription factors participate in a diverse array of processes, including acute responses to injury and infection, lymphocyte differentiation, and embryonic patterning. These proteins show homology in an extended region spanning about 300 amino acids (the Rel homology domain [RHD]). The RHD mediat...

journal_title：Molecular and cellular biology

authors： Tatei K,Levine M

更新日期：1995-07-01 00:00:00

abstract：:The RAD1 gene of Saccharomyces cerevisiae is required for the incision step of excision repair of damaged DNA. In this paper, we report our observations on the effect of the RAD1 gene on genetic recombination. Mitotic intrachromosomal and interchromosomal recombination in RAD+, rad1, rad52, and other rad mutant strain...

journal_title：Molecular and cellular biology

authors： Schiestl RH,Prakash S

更新日期：1988-09-01 00:00:00

abstract：:The Ran binding protein RanBP1 is localized to the cytosol of interphase cells. A leucine-rich nuclear export signal (NES) near the C terminus of RanBP1 is essential to maintain this distribution. We now show that RanBP1 accumulates in nuclei of cells treated with the export inhibitor, leptomycin B, and collapse of th...

journal_title：Molecular and cellular biology

authors： Plafker K,Macara IG

更新日期：2000-05-01 00:00:00