Antiischemic effects of nifedipine in isolated working heart preparations of healthy, diabetic, and hypertensive rats.

abstract：:Adenosine protects the ischemic myocardium by coronary vasodilation and the depression of heart rate and contractility, improving myocardial energy balance. Adenosine effects on the myocardium are mediated predominantly by the type A1 receptors. Atrial natriuretic peptide (ANP), a vasodilator and regulator of blood vo...

journal_title：Journal of cardiovascular pharmacology

authors： Salman H,Bergman M,Schlesinger H,Zahavi I,Kessler-Icekson G

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Dopamine is an inotrope effective in the short term treatment of acute heart failure - including that caused by coronary artery disease. Catecholamines however can potentiate platelet activation and pre-dispose to coronary thrombosis. AIMS:Dopamine was studied for effect on agonist induced human platelet Ca...

journal_title：Journal of cardiovascular pharmacology

authors： Sill JC,Bertha B,Berger I,Southorn V,Folts J

更新日期：2009-03-01 00:00:00

abstract：:In addition to the hemodynamic components, the roles of various humoral factors have been emphasized in the progression of vascular and renal injury in hypertension. Radical scavenging properties have attracted much attention in this field. This article discusses the implication of antioxidant properties of the antihy...

journal_title：Journal of cardiovascular pharmacology

authors： Uehara Y,Kawabata Y,Shirahase H,Wada K,Hashizume Y,Morishita S,Numabe A,Iwai J

更新日期：1993-01-01 00:00:00

abstract：:The heavy impact of obesity on the development and progression of cardiovascular disease has sparked sustained efforts to uncover the mechanisms linking excess adiposity to vascular dysfunction. In addition to its well-established role in maintaining vascular homeostasis, the endothelium has been increasingly recogniz...

journal_title：Journal of cardiovascular pharmacology

authors： Schinzari F,Tesauro M,Cardillo C

更新日期：2017-06-01 00:00:00

abstract：:The positive inotropic action of phenylephrine in cardiac muscle is mediated by alpha- and beta-adrenoceptors. Data suggest the responsiveness of myocardium to inotropic agents is altered in cardiac disease. We evaluated the actions of phenylephrine on isometric contraction and K+-induced contracture in isolated cat r...

journal_title：Journal of cardiovascular pharmacology

authors： Gaide MS,Wiggins JR,Fitterman WS,Cameron JS,Myerburg RJ,Bassett AL

更新日期：1984-03-01 00:00:00

abstract：:We previously showed that rat and cow blood vessels contain arginine vasopressin (AVP) of local origin. In the present study, to investigate potential roles for this locally produced peptide, we examined the effects of AVP on growth of cultured vascular endothelial and smooth muscle cells (EC, SMC). Treatment of cultu...

journal_title：Journal of cardiovascular pharmacology

authors： Simon JS,Baum JS,Moore SA,Kasson BG

更新日期：1995-03-01 00:00:00

abstract：:It has been proposed that cholinergic agonists inhibit the sinoatrial node discharge by shifting the activation range of the hyperpolarization-activated inward current If to more negative values or by increasing potassium conductance. In the former instance, cesium will potentiate the cholinergic inhibition by blockin...

journal_title：Journal of cardiovascular pharmacology

authors： Vassalle M,Zhang H

更新日期：2001-02-01 00:00:00

abstract：:Endothelial damage triggers platelet adhesion and platelet-associated prothrombinase formation at the point of injury, resulting in the progression of thrombus formation. The present study compared the inhibitory effects of fondaparinux, an indirect factor Xa (FXa) inhibitor, and TAK-442, a direct FXa inhibitor, on pl...

journal_title：Journal of cardiovascular pharmacology

authors： Konishi N,Hiroe K,Kawamura M

更新日期：2011-02-01 00:00:00

abstract：:The target proteins for calcium, when it acts as a second messenger, are a group of intracellular, specific calcium-binding proteins that contain EF-hand structures. Calmodulin regulates a number of Ca2+-dependent processes and is present in all eukaryotic cells. Parvalbumin, the S-100 proteins, two vitamin D-dependen...

journal_title：Journal of cardiovascular pharmacology

authors： Heizmann CW

更新日期：1986-01-01 00:00:00

abstract：:Chronic uremia and metabolic acidosis impair vascular responses to norepinephrine (NE) and also cause multiple metabolic defects in skeletal muscle. These studies were conducted to determine whether decreased vascular responsiveness resulted from putative second messenger metabolism. Tail arteries were used from rats ...

journal_title：Journal of cardiovascular pharmacology

authors： Fox AW,May RE,Mitch WE

更新日期：1992-08-01 00:00:00

abstract：:Adenosine and verapamil have successfully been used in the treatment of clinical no-reflow after direct angioplasty for acute myocardial infarction. However, their effects on anatomic perfusion defects in experimental myocardial ischemia/reperfusion are unknown. Thus the area of no-reflow (ANR), visualized after in-vi...

journal_title：Journal of cardiovascular pharmacology

authors： Reffelmann T,Kloner RA

更新日期：2004-04-01 00:00:00

abstract：:The antihypertensive effect of the combination of ketanserin, a new antiserotonergic agent, and thiazide has been evaluated in 35 patients with arterial hypertension of mild to moderate degree in the greater than 50-year-old age group. Twenty patients were given ketanserin (20 mg) + hydrochlorothiazide (25 mg) (treatm...

journal_title：Journal of cardiovascular pharmacology

authors： Ferrara LA,Fasano ML,Soro S,Pasanisi F,Mancini M

更新日期：1987-01-01 00:00:00

abstract：:The effects of cibenzoline were examined in the dog with multifocal ventricular arrhythmias 24 h after ligation of the left anterior descending coronary artery, and on isolated, superfused canine cardiac tissues which were studied using standard microelectrode techniques. In the intact dog, 5 mg/kg cibenzoline consist...

journal_title：Journal of cardiovascular pharmacology

authors： Dangman KH

更新日期：1984-03-01 00:00:00

abstract：:The pharmacologic profile of SK-1080, a nonpeptide AT1-selective angiotensin-receptor antagonist, was investigated by receptor-binding studies, functional in vitro assays with rabbit and rat aorta, and in vivo experiments in pithed rats. SK-1080 inhibited the specific binding of [125I]-[Sar1, Ile8]-angiotensin II to h...

journal_title：Journal of cardiovascular pharmacology

authors： Lee SH,Jung YS,Lee BH,Yun SI,Yoo SE,Shin HS

更新日期：1999-03-01 00:00:00

abstract：:During myocardial ischemia, the extracellular potassium concentration increases in a triphasic pattern, an initial early increase, a constant phase, and a late increasing phase. The aim of this study was to determine whether diltiazem inhibits the late increasing phase by maintaining glycolytic adenosine triphosphate ...

journal_title：Journal of cardiovascular pharmacology

authors： Sakamoto K,Yamazaki J,Nagao T

更新日期：1997-10-01 00:00:00

abstract：:We investigated the effects of endothelin (ET) and thrombin on the production of interleukin 6 (IL-6) in human umbilical vein endothelial cells (HUVECs). ET-1 increased IL-6 production twofold in HUVECs incubated for 18 h with 10(-10) M ET-1. Thrombin also significantly increased IL-6 production. However, stimulation ...

journal_title：Journal of cardiovascular pharmacology

authors： Stanková J,Rola-Pleszczynski M,D'Orléans-Juste P

更新日期：1995-01-01 00:00:00

abstract：:This report summarizes the most important results of 11 studies regarding efficacy and safety of bisoprolol in patients with stable angina pectoris due to coronary heart disease. Assessments carried out 2-3 h after the administration of the beta 1-selective adrenoceptor blocking agent bisoprolol revealed that the dose...

journal_title：Journal of cardiovascular pharmacology

authors： Wagner G

更新日期：1986-01-01 00:00:00

abstract：:CGS 26303 has previously been shown to inhibit human endothelin converting enzyme-1 (ECE-1) with an IC50 of 410 nM and to be efficacious in several animal disease models. However, it is a more potent inhibitor of neutral endopeptidase 24.11 (NEP) with an IC50 of 1 nM. The aim of this study was to optimize CGS 26303 fo...

journal_title：Journal of cardiovascular pharmacology

authors： Jeng AY,De Lombaert S,Beil ME,Bruseo CW,Savage P,Chou M,Trapani AJ

更新日期：2000-11-01 00:00:00

abstract：:Nonsedating H1-receptor antagonists appear to have wide and variable effects on the QT interval, mediated through modulation of cardiac K+ channels. By using the whole-cell patch-clamp technique, we examined the effects of terfenadine, loratadine, and descarboethoxyloratadine on a large family of K+ channels in ventri...

journal_title：Journal of cardiovascular pharmacology

authors： Ducic I,Ko CM,Shuba Y,Morad M

更新日期：1997-07-01 00:00:00

abstract：:Inclacumab is a novel monoclonal antibody directed against P-selectin in development for the prevention and treatment of atherosclerotic cardiovascular diseases. It is likely to be used concomitantly with heparin in patients undergoing percutaneous coronary intervention. Coadministration of both drugs may potentially ...

journal_title：Journal of cardiovascular pharmacology

authors： Schmitt C,Mudie N,Ciorciaro C,Gaudreault J

更新日期：2015-04-01 00:00:00

abstract：:Endothelin (ET) receptor subtypes in human prostate with benign prostatic hyperplasia were investigated by binding and functional studies. In the displacement experiment, LU224332 [endothelin-A/-B (ET(A)/ET(B)) nonselective antagonist] competed for [125I]ET-1 binding with a monophasic curve. On the other hand, LU13525...

journal_title：Journal of cardiovascular pharmacology

authors： Hiraoka Y,Oshita M,Morikawa K,Nagata O,Hahn KJ,Hahn A,Okada K,Taniguchi T,Muramatsu I

更新日期：2000-11-01 00:00:00

abstract：:The aim of this study was to determine whether tumor necrosis factor (TNF)-alpha would impair basal and stimulated endothelium-dependent vasomotion in human resistance vessel. Changes in baseline and acetylcholine (ACh)-induced forearm vascular resistance (FVR) were measured plethysmographically before and after a low...

journal_title：Journal of cardiovascular pharmacology

authors： Nakamura M,Yoshida H,Arakawa N,Saitoh S,Satoh M,Hiramori K

更新日期：2000-10-01 00:00:00

abstract：:One possible mechanism that accounts for the alterations observed in varicose veins is the activation of endothelial cells by ischemia occurring in the leg veins during blood stasis and the cascade of reactions that follows. Because in vitro data suggest that endothelium alteration is a key event in the development of...

journal_title：Journal of cardiovascular pharmacology

authors： Janssens D,Michiels C,Guillaume G,Cuisinier B,Louagie Y,Remacle J

更新日期：1999-01-01 00:00:00

abstract：:Recent studies have shown the ability of salicylic acid (SA) to trap hydroxyl radicals (OH.) generated during reperfusion in ischemic myocardium. Since OH. is implicated in the pathogenesis of reperfusion injury, we examined the effect of SA on reperfusion-induced arrhythmias and postischemic ventricular dysfunction. ...

journal_title：Journal of cardiovascular pharmacology

authors： Liu XK,Tosaki A,Engleman RM,Das DK

更新日期：1992-02-01 00:00:00

abstract：:The main therapeutic strategies for treating atrial fibrillation include rate control, maintenance of sinus rhythm, and antiembolic treatment. Current antiarrhythmic drugs are effective in about 50% of patients and are often associated with adverse effects. Multiple trials suggest that rate control with proper anticoa...

journal_title：Journal of cardiovascular pharmacology

authors： Naccarelli GV,Gonzalez MD

更新日期：2008-09-01 00:00:00

abstract：:N-[3,5-Dichlorophenyl] 4-[4-hydroxy-2-methoxy-phenyl] piperazine carboxamidine dihydrochloride (RS-87337) is a chemically novel antiarrhythmic agent with an electrophysiologic profile characteristic of both class III and class Ia compounds as defined by Vaughan-Williams and Campbell. In isolated superfused guinea pig ...

journal_title：Journal of cardiovascular pharmacology

authors： Dumez D,Patmore L,Ferrandon P,Allely M,Armstrong JM

更新日期：1989-08-01 00:00:00

abstract：:Arrhythmias occur 24 h after occlusion of the left anterior descending (LAD) coronary artery in the canine heart and have been attributed to the abnormal spontaneous activity in subendocardial Purkinje fibers, which are markedly depolarized. The major current underlying normal automaticity in these fibers is i(f). Alt...

journal_title：Journal of cardiovascular pharmacology

authors： Lasker SM,Han D,Kline RP

更新日期：1997-05-01 00:00:00

abstract：:Halothane opposes cardiotoxicity of neutral-sugar digitalis compounds in intact animals, presumably by depressing a sympathetic component of arrhythmogenesis. However, halothane also produces a dose-related reduction in arrhythmogenicity of ouabain in isolated canine Purkinje fibers, suggesting that the anesthetic may...

journal_title：Journal of cardiovascular pharmacology

authors： Heerdt PM,Gallagher JD,Caldwell RW

更新日期：1994-06-01 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPAR) play a critical physiological role in energy homeostasis, in inflammation, and a protective role in cardiovascular function. We assessed the antioxidant effect of clofibrate-induced Peroxisome proliferator-activated receptor alpha (PPARα) stimulation on ischemic myoca...

journal_title：Journal of cardiovascular pharmacology

authors： Ibarra-Lara L,Hong E,Soria-Castro E,Torres-Narváez JC,Pérez-Severiano F,Del Valle-Mondragón L,Cervantes-Pérez LG,Ramírez-Ortega M,Pastelín-Hernández GS,Sánchez-Mendoza A

更新日期：2012-10-01 00:00:00

abstract：:Dihydropyridine calcium antagonists play an important role in the treatment of arterial hypertension. In many centers, they are used as first-line treatment. Since impaired renal function can be a complication of long-standing blood pressure elevation, the usefulness of dihydropyridine calcium antagonists in hypertens...

journal_title：Journal of cardiovascular pharmacology

authors： Hansson LH

更新日期：1989-01-01 00:00:00