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Absence of cerebrospinal fluid oligoclonal bands is associated with delayed disability progression in relapsing-remitting MS patients treated with interferon-beta.

Abstract：

:To assess the role of CSF oligoclonal bands (OB) in determining the clinical outcome in patients with relapsing-remitting multiple sclerosis (RRMS) treated with IFN-beta, we carried out a retrospective, multicentre, observational study recruiting 209 RRMS patients from six MS centres from northern, central and southern areas of Italy under treatment with IFN-beta-1a i.m., IFN-beta-1a s.c. and IFN-beta-1b s.c. Twenty-two of 209 patients (10.6%) showed no OB in CSF. The patients without had, at disease onset, significantly higher frequency of visual disturbances (p=0.02) and less sensory involvement (p=0.04) than those with OB. A statistical trend (p=0.056) towards a longer time to reach sustained disability progression during treatment was found in patients without compared to those with OB. Thirty-six of 187 (19%) patients with OB worsened by at least 1 EDSS point compared to none of 22 (0%) OB-negative patients (p=0.017). The delaying of disability progression in OB-negative patients during treatment was significantly dependent only on the number of baseline MRI T2-weighted lesions (p=0.012) that was found to be significantly lower in OB-negative than in OB-positive patients (p=0.04). The absence of OB and low number of baseline T2-weighted lesions in this cohort of MS patients are favourable prognostic factors influencing the clinical response to IFN-beta treatment in RRMS patients.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Annunziata P,Giorgio A,De Santi L,Zipoli V,Portaccio E,Amato MP,Clerici R,Scarpini E,Moscato G,Iudice A,Vacca G,Orefice G,Morra VB,Maimone D

doi

10.1016/j.jns.2006.01.004

subject

Has Abstract

pub_date

2006-05-15 00:00:00

pages

97-102

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(06)00009-8

journal_volume

244

pub_type

杂志文章,多中心研究

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