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Management of glioblastoma in elderly patients.

Abstract：

:Glioblastoma (GBM) is the most common primary malignant brain tumor in adults over 55years of age. The median age of diagnosis for patients with GBM is 64years old, with the incidence of patients between 75 and 85 increasing. The optimal treatment paradigm for elderly GBM patients continues to evolve due to the higher frequency of age-related and/or medical co-morbidities. Geriatric GBM patients have historically been excluded from larger, controlled clinical trials due to their presumed decreased likelihood of a sustained treatment response and/or a prolonged good outcome. Here, we highlight current treatment considerations of elderly GBM patients with respect to surgical, radiotherapeutic and systemic modalities, with considerations for improving future clinical outcomes for this patient population.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Young JS,Chmura SJ,Wainwright DA,Yamini B,Peters KB,Lukas RV

doi

10.1016/j.jns.2017.07.048

subject

Has Abstract

pub_date

2017-09-15 00:00:00

pages

250-255

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(17)30482-3

journal_volume

380

pub_type

杂志文章,评审

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