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Origin of the triosephosphate isomerase isozymes in humans: genetic evidence for the expression of a single structural locus.

Abstract：

:A genetic approach is used to ascertain that a single structural locus for triosephosphate isomerase (TPI) (E.C.5.3.1.1.) is expressed in rapidly dividing human lymphoblasts. This approach is made possible through the identification of a rare electrophoretic variant of human TPI. The variant phenotype is expressed by the TPI-B isozyme in both erythrocytes and peripheral lymphocytes. The variant phenotype is also expressed in the thermostability and electrophoretic pattern of the TPI-A isozyme in mitogen-stimulated lymphoblasts, indicating that TPI-A and TPI-B are products of the same structural locus. These findings are in contrast to the recent conclusions of Yuan et al. based upon structural analysis, suggesting that the TPI-A and TPI-B isozymes are products of distinct structural loci.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Decker RS,Mohrenweiser HW

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

683-91

issue

5

eissn

0002-9297

issn

1537-6605

journal_volume

33

pub_type

杂志文章

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